Classification of adverse reactions according to the frequency of development: very often (≥ 1/10); often (≥1/100 up to <1/10); infrequently (≥ 1/1000 to <1/100); rarely (≥ 1/10 000 to <1/1000); very rarely (<1/10000); * - not known (can not be determined from available data).
Disorders from the gastrointestinal tract: often - nausea, vomiting, absence appetite, the frequency and severity of which depends on the dose. Rarely - diarrhea, pancreatitis; pain in a stomach*. The frequency of side effects decreases with taking the drug with food and a lot of liquid.
Infectious and parasitic diseases: pseudomembranous colitis
Impaired nervous system: often a headache. Dizziness *, asthenia *, nystagmus *, drowsiness *. Rarely - increased intracranial pressure. In some cases: in patients with insufficient liver function, anemia, diabetes mellitus, electrolyte imbalance, deficiency of B vitamins, serious peripheral polyneuropathies are possible, the first symptoms of which are numbness and burning sensation in the legs, muscle weakness. With these symptoms, the drug should be discontinued.
Disturbances from the respiratory system, chest and mediastinal organs: acute and chronic reactions of hypersensitivity of the lungs, characterized by fever, eosinophilia, cough, chest pain, dyspnea. Interstitial changes in the lungs, bronchoobstructive syndrome. Pulmonary infiltrate or compression and pleural effusion may occur within a few hours or days from the start of therapy; After stopping the drug, they usually resolve. Subacute or acute pulmonary symptoms, including fibrosis of the lungs, can develop imperceptibly in patients with prolonged therapy; Fibrosis may be irreversible, especially if therapy continues after the onset of symptoms. When the first reactions of hypersensitivity of the lungs appear, the drug should be discontinued.
Disorders from the liver and / or bile ducts: rarely hepatitis,Cholestatic jaundice (dozonezavisimy and pass after drug withdrawal).
Disorders from the rut and subcutaneous tissues: often allergic reactions - dermal rashes, hives, itching; in some cases - inflammation of the salivary glands, exfoliative dermatitis, polymorphic erythema.
Violations of the blood and lymphatic system: rarely - megaloblastic anemia, leukopenia, granulocytopenia or agranulocytosis, thrombocytopenia,hemolytic anemia in patients with deficiency of glucose-6-phosphate dehydrogenase.
Immune system disorders: in some cases - angioedema, anaphylaxis. In some cases - autoimmune reactions, mainly associated with chronic changes in the lungs or liver. The symptoms of this syndrome volchanochnopodobnogo - rash, eosinophilia, fever, arthralgia, eosinophilia short term, while in the blood serum, an increase of at least two parameters - antinuclear antibodies, antibodies to smooth muscle or to the glomerular basement membrane, and Coombs' test.
Violations from the genitals and breast: in very rare cases - passing violation of spermatogenesis.
Others: rarely - pain in the joints, reversible hair loss.
If you notice any side effects not listed in this manual, or any of these side effects is expressed particularly strongly, should consult with your doctor about whether to continue using the drug.