Fusidic acid refers to the group of fusidins, antimicrobial compounds whose mechanism of action is associated with a violation of protein synthesis in a bacterial cell. By blocking the elongation of factor G, they prevent its binding to ribosomes and GTP (guanosine triphosphate), which interrupts the release of energy required for synthesis.
Fusidic acid is sensitive to gram-positive bacteria and Gram-negative cocci, for example, Staphylococcus aureus, Coryriebacterium minutissimum, Streptococcus pyogenes, Pseudomonas spp., Clostridium spp
'Inactive with Escherichia coli, Salmonella spp.', Proteus spp. th other gram-negative bacteria, as well as protozoa and fungi.