Intravenously sprayed, once through the catheter with a syringe. With a patient's body weight of up to 100 kg, 0.1 mmol / kg (0.2 ml / kg); with a body weight of more than 100 kg - 10 mmol (20 ml). The drug is injected into the syringe immediately before use; To ensure complete administration of the dose, the cannula is washed with 5 ml of a 0.9% solution of sodium chloride. The beginning of the study - a few minutes after the introduction, the end - for 1 hour (no more).
With MRI, the heart performs two injections to study myocardial perfusion under load and at rest. 2 hours before the procedure, the patient should not eat. When performing an intravenous bolus injection for MRI of the heart, it is recommended to use a suitable injector at a rate of infusion of up to 8 ml / s. When the drug is administered, the patient should be in a horizontal position.Within 30 minutes after the end of the procedure, medical supervision of the patient is carried out. It is during this period that most of the adverse reactions occur.
Contrasting the central nervous system (CNS)
The recommended dose for adults and children is 0.1 mmol / kg body weight (equivalent to 0.2 ml / kg body weight) per body weight up to 100 kg; with a body weight of more than 100 kg is usually sufficient to provide a diagnostic adequate contrast of 20 ml.
If there is a suspicion of brain metastases, a dose of 0.3 mmol / kg body weight (equivalent to 0.6 ml / kg body weight) may be administered to adults with a body weight of up to 100 kg.
With a body weight of more than 100 kg, a dose of 60 ml is usually sufficient. A dose of 0.3 mmol / kg body weight can be administered in the form of a single bolus injection. In the case of indistinct images after injection, a second bolus injection at a dose of 0.1 mmol / kg of body weight is administered after 20 minutes at a dose of 0.2 mmol / kg body weight (equivalent to 0.4 ml / kg body weight).
Contrasting the whole body
For adults and children older than 6 months, the recommended dose is 0.1 mmol / kg body weight (equivalent to 0.2 ml / kg body weight) with a body weight of up to 100 kg or, in some cases, 0.3 mmol / kg body weight ( is equivalent to 0, 6 ml / kg of body weight).If the patient has a body weight of more than 100 kg, 20 ml, or 60 ml, is usually sufficient for diagnostic contrasting (for some cases). The required dose should be administered once intravenously.
MRI in contrast enhancement should be started immediately after the administration of contrast medium, depending on the pulse mode used and the protocol of the study. The optimum gain is noted a few minutes after the injection (time is determined by the type of tissue damage). Usually, the gain is maintained up to 45 minutes after the administration of contrast medium. With contrast enhancement by the gadodiomide, it is optimal to use T1-weighted pulse sequences.
Angiography
For adult patients, the recommended dose is usually 0.1 mmol / kg body weight (equivalent to 0.2 ml / kg body weight). In the case of stenosis of abdominal and iliac arteries, a higher dose up to 0.3 mmol / kg of body weight (equivalent to 0.6 ml / kg) is used, which allows obtaining additional diagnostic information. For optimal contrast, visualization should be performed on the first pass of the contrast medium, during and immediately after injection, depending on the equipment used.
CHD
For adult patients, the recommended dose for assessing myocardial perfusion is usually 0.15 mmol / kg body weight (equivalent to 0.3 ml / kg body weight), which is divided into 2 separate doses of 0.075 mmol / kg body weight (equivalent to 0.15 ml / kg body weight) and administered at an interval ≥10 minutes. The first injection is administered under conditions of pharmacological stress, the second - at rest. The drug that causes pharmacological stress should be injected through a separate catheter. In the case of evaluation of late gain, a total dose of 0.15 mmol / kg body weight is recommended. In patients 65 years of age and older, dose adjustment is not required.