The drug is intended for intravenous administration.
Like all preparations for parenteral administration, Omniscan® should be inspected (visually) before administration for the absence of mechanical inclusions, discoloration, and packaging integrity problems.
Special patient preparation is not required. Omniskan® is recruited in. syringe immediately before use. Adults and children should be given the required dose in the form of a single intravenous injection.
In MRI, the heart performs two injections to study perfusion under load and at rest. When performing an intravenous bolus injection for MRI of the heart, it is recommended to use a suitable injector with a contrast medium delivery rate of up to 8 ml / s.
In order to ensure the introduction of a full dose of contrast medium, the dropper can be washed with 0.9% sodium chloride solution.
With intravenous jet injection, once with a syringe through the catheter.Omniscan® should be dialed into the syringe immediately before use. 2 hours before the procedure, the patient should stop eating.
When the drug is administered, the patient should be in a horizontal position. Within 30 minutes after the end of the procedure, the patient is monitored physically, because It is during this period that most of the adverse reactions occur. In children under 1 year and patients with moderate-type kidney disease (glomerular filtration rate 30-59 ml / min / 1.73 m2), the use of the drug should be evaluated in terms of risk-benefit and limited to the introduction of a standard dose (0.1 mmol / kg body weight). Repeated administration of the drug should not be performed earlier than 7 days later.
Contrasting the central nervous system
For adults and children over 4 weeks.
The recommended dosage is 0.1 mmol / kg body weight (equivalent to 0.2 ml / kg body weight) with a body weight of up to 100 kg; more than 100 kg - 20 ml is usually enough to provide a diagnostically adequate contrast. The required dose should be administered once intravenously.
To ensure the completeness of the drug, the intravenous catheter should be washed with a sufficient amount of 0.9% sodium chloride solution.
For adult patients
If there is a suspicion of metastases in the brain, a dose of 0.3 mmol / kg bw may be administered to patients weighing up to 100 kg. (equivalent to 0.6 ml / kg of body weight). With a body weight of more than 100 kg, a dose of 60 ml is usually sufficient. A dose of 0.3 mmol / kg body weight could be. is administered in the form of a bolus injection. In the case of indistinct images after injection, a second bolus injection at a dose of 0.1 mmol / kg of body weight is administered after 20 minutes at a dose of 0.2 mmol / kg body weight (equivalent to 0.4 mg / kg body weight).
Contrasting the whole body
For adult patients
For patients weighing up to 100 kg, the recommended dosage is usually 0.1 mmol / kg body weight (equivalent to 0.2 ml / kg body weight) or, in some cases, 0.3 mmol / kg bw. (equivalent to 0.6 ml / kg of body weight). If the patient has a body weight of more than 100 kg, 20 ml, or 60 ml, is usually sufficient for diagnostic contrasting (for some cases).
For children over 6 months
The recommended dosage is 0.1 mmol / kg bw. (equivalent to 0.2 ml / kg of body weight)
As with adults, the necessary dose should be administered once intravenously.
Magnetic Resonance Study
MRI in conditions of contrast enhancement should be started soon after the administration of the contrast medium, depending on the pulse mode used and the protocol of the study.The optimum gain is observed a few minutes after the injection (time is determined by the type of lesion / tissue). Usually, the gain is maintained up to 45 minutes after the administration of contrast medium. With contrast enhancement Omniskan®, it is optimal to use T1-weighted pulse sequences. In the studied range of field strengths from 0.15 Tesla to 1.5 Tesla, the relative contrast of the image does not depend on the applied field strength.
Angiography
For adult patients
The recommended dosage is usually 0.1 mmol / kg (0.2 ml / kg).
In the case of stenosis of the abdominal and iliac arteries, a higher dose of 0.3 mmol / kg (equivalent to 0.6 ml / kg) is used, which allows "additional diagnostic information."
For optimal contrast, visualization should be performed on the first pass of the contrast medium, during and immediately after injection, depending on the equipment used.
Ischemic heart disease (CHD)
For adult patients
The recommended dosage for evaluation of cardiac perfusion is 0.15 mmol / kg body weight (equivalent to 0.3 ml / kg body weight), which is divided into 2 separate doses of 0.075 mmol / kg body weight (equivalent to 0.15 ml / kg body weight ) and administered at intervals ≥10 minutes.The first injection is administered under conditions of pharmacological stress, the second - at rest.
The drug that causes pharmacological stress should be injected through a separate catheter. In the case of evaluation of late gain, a total dose of 0.15 mmol / kg body weight is recommended. The use of the drug according to the indications of CHD in children has not been studied.