Included in the formulation
АТХ:L.03.A.X Other immunostimulants
Pharmacodynamics:A synthetic preparation consisting of D-amino acid residues of glutamine and tryptophan, suppresses the response of cellular and humoral immunity, reduces the number of blood lymphocytes in expressed autoimmune processes, proportionately reduces the number of helpers and suppressors, while retaining the number of stem cells. Reduces the recovery period of populations of polypotent (CFU-C12) and committed (CFU-C8) precursors of hemopoiesis after the action of cytostatics.
Oppresses the production of tumor necrosis factor α (TNF-α), increases the production of interleukin 7, without interfering with the production of interleukin 1.
It does not have teratogenic and mutagenic properties, it is non-toxic.
Pharmacokinetics:After intramuscular injection, the maximum concentration in the blood plasma is reached after 5 minutes.
Metabolism in the liver.
The half-life is 14 hours. Elimination by the kidneys and with feces within 24 hours. Does not accumulate in the body.
Indications:It is used for conditions accompanied by hyperimmune reactions: primary and secondary autoimmune single-, double- and triple-cytopenia, hypoplastic anemia.It is used for the preservation of stem cells and for the prevention of granulocytopenia in the treatment of chemotherapeutic and cytostatic drugs.
II.C81-C96.C84 Peripheral and cutaneous T-cell lymphomas
III.D55-D59.D59.1 Other autoimmune hemolytic anemia
III.D65-D69.D69.3 Idiopathic thrombocytopenic purpura
III.D70-D77.D70 Agranulocytosis
XII.L10-L14.L10 Pemphigus [pemphigus]
XII.L20-L30.L20.8 Other atopic dermatitis
XII.L20-L30.L28.0 Simple chronic lichen
XII.L40-L45.L40 Psoriasis
XIII.M05-M14.M05 Seropositive rheumatoid arthritis
XXI.Z20-Z29.Z29.8 Other specified preventive measures
XXI.Z80-Z99.Z94 Presence of transplanted organs and tissues
Contraindications:Infectious diseases in the acute phase, uncontrolled arterial hypertension, individual intolerance.
Carefully:Latent and chronic forms of infectious diseases.
Pregnancy and lactation:Recommendations for FDA - Category C. Contraindicated in pregnancy and lactation.
Dosing and Administration:Use in children
2-12 years: intramuscularly, 0.5-1 ml once a day for 7-10 days with a break for 2 days. It is allowed to hold 1 to 5 courses.
Older than 12 years: intramuscularly, 1-2 ml 1 time per day for 7-10 days, with a break for 2 days, then repeat the course for 7-10 days.
Adults
Intramuscularly for 1-2 ml of 0.1% solution for 7 days. If necessary, repeated courses are conducted with an interval of 7 days.
The highest daily dose: 200 mg.
The highest single dose: 200 mg.
Side effects:Transient leukocythemia, allergic reactions.
Overdose:Cases of overdose are not described.
Treatment is symptomatic.
Interaction:Clinically significant interactions were not detected.
Special instructions:The use of the drug helps exacerbate latent viral, bacterial, parasitic and fungal infections.
Treatment with the drug should be under the supervision of a doctor who has experience of immunosuppressive therapy.