Active substanceGamma-D-glutamyl-tryptophanGamma-D-glutamyl-tryptophan Similar drugsTo uncover Bestim® lyophilizate inwards GosNII OCHB FMBA, FSUE Russia Dosage form: & nbsplyophilizate for the preparation of a solution for intramuscular injection Composition:1 ampoule: Active ingredient: "Bestim®" (gamma-D-glutamyl-tryptophan sodium) - 100 μg; auxiliary components: sodium chloride 1.0 mg, mannitol 9.0 mg. Description:White powder or porous mass without a smell. Pharmacotherapeutic group:Immunostimulating agent ATX: & nbspL.03.A.X Other immunostimulants Pharmacodynamics:Gamma-D-glutamyl-tryptophan sodium is a dipeptide with immunostimulating action. Stimulates cellular and humoral immunity. Increases antibacterial and antiviral resistance. The pharmacological action is determined by increased differentiation and proliferation of T lymphocyte progenitors, stimulation of interleukin-2 production, increased expression of interleukin-2 receptors and T-cell differentiation markers, and restoration of the immunoregulatory index. Application of the preparation Bestim® in the complex treatment of diseases accompanied by secondary immunodeficiencies, significantly increases its effectiveness. The drug is effective when included in the complex therapy of viral diseases; accompanied by a lack of cellular immunity. Pharmacokinetics:The distribution of the drug in the body is limited by the extracellular water phase. The drug is rapidly excreted from the systemic circulation - the average time of its circulation is 10-11 min; the elimination rate is characterized by high clearance - 25-30 ml / kg / min. From the body the drug is excreted in the form of metabolites with urine and feces. Indications:Complex therapy of secondary immunodeficient conditions developing after severe trauma on the background of purulent-septic and purulent-destructive processes, after extensive surgical interventions, in chronic septic states with the phenomena of anergy, as well as in infectious diseases (viral hepatitis, tuberculosis, chlamydia). Contraindications:Individual drug intolerance, allergic and autoimmune diseases (urticaria, Quincke's edema, Lyell's syndrome, systemic connective tissue diseases), pregnancy and lactation period, children's age. Pregnancy and lactation:The drug is contraindicated. Dosing and Administration:Intramuscularly 100 μg in the volume of 1 ml of water for injection once a day daily. The course of treatment - five injections. Side effects:In some cases, nausea and dizziness may occur. If any of the specified in the side instructions. the effects are aggravated, or you notice any other side effects not listed in the instructions, inform the doctor about it. Overdose:To date, no cases of overdose, accompanied by any clinical symptoms. However, as with an overdose of any drug, symptomatic therapy should be performed with monitoring the functions of vital organs and regular monitoring of the patient's condition. Interaction:With the simultaneous application of Bestim® increases the clinical effectiveness of anti-tuberculosis drugs (isoniazid, rifampicin, pyrazinamide, ethambutol, ciprofloxacin) in the complex therapy of pulmonary tuberculosis; antibiotics of various groups (azithromycin, rovamycin, doxycycline) and antimicrobial agents of the fluoroquinolones group (lomefloxacin, sparfloxacin) in the complex therapy of urogenital chlamydiosis; antiviral drug ribavirin in the complex therapy of viral hepatitis C. Special instructions:Given the potential for dizziness, care should be taken when driving vehicles and working with precise mechanisms. Form release / dosage:Lyophilizate for the preparation of solution for intramuscular injection. Packaging:100 μg in an ampoule of colorless glass. 5 ampoules in a cassette contour pack. 1 cassette contour pack together with instructions for use in a pack of cardboard. Storage conditions:In the dark place at a temperature of 2 to 10 ° C. Keep out of the reach of children. Shelf life:2 years. Do not use after the expiration date. Terms of leave from pharmacies:On prescription Registration number:P N003335 / 03 Date of registration:03.08.2010 / 16.12.2016 Expiration Date:Unlimited The owner of the registration certificate:GosNII OCHB FMBA, FSUE GosNII OCHB FMBA, FSUE Russia Manufacturer: & nbspGosNII OCHB FMBA FSUE Russia Information update date: & nbsp24.01.2017 Illustrated instructions × Illustrated instructions Instructions