Hemodez-H (Haemodes-N)

Composition Pharmacodynamics Indications Carefully Contraindications Dosing and Administration Side effects Form release / dosage
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Dosage form: & nbspsolution for infusions
Composition:

Active substances: polyvinylpyrrolidone low molecular weight medical 8000 ± 2000 for the preparation of Hemodez-H (povidone) 60.0 g, sodium chloride 5.5 g; potassium chloride 0.42 g, calcium chloride hexahydrate 0.50 g,magnesium chloride hexahydrate 0.005 g, sodium hydrogen carbonate 0.23 g;

auxiliary substance: water for injection up to 1 liter.

Ionic composition:

In a liter of the drug contains:

Sodium ion 96.9 mmol;

Potassium ion 5.6 mmol;

Calcium ion 2.3 mmol;

Magnesium ion 0.025 mmol;

Chloro-ion 104.4 mmol;

Hydrocarbonate ion 2.7 mmol.

Theoretical osmolarity is ~ 235.4 mOsm / l.

Description:Transparent liquid of light yellow and yellow color.
Pharmacotherapeutic group:Detoxifying agent
ATX: & nbsp
  • Blood plasma preparations and plasma-substituting drugs
    • Pharmacodynamics:

    The effect of the drug is due to the ability of low molecular weight povidone to bind toxins that circulate in the blood and quickly remove them from the body.

    The most fully binds toxins circulating in the blood of patients with shigellosis, salmonellosis, food intoxication.

    At a burn disease at different periods of the disease, different toxins are produced. Those of them that are formed in the first 4-5 days of the disease are quite fully bound and quickly removed from the body; toxins formed at a later date are significantly weaker.

    The drug contributes to the elimination of stasis of erythrocytes in capillaries, developing with intoxication of any origin, which leads to an improvement in microcirculation.It increases renal blood flow, increases glomerular filtration and increases diuresis.

    The drug is non-toxic, does not have pyrogenic properties.

    Hemodez-H differs from Hemodesa by a lower molecular weight of polyvinylpyrrolidone.

    The decrease in the molecular weight of the polymer accelerates the excretion of it by the kidneys from the body and improves the detoxification properties of the preparation.

    Potassium chloride - the main intracellular ion, plays an important role in the regulation of various functions of the body. It participates in the maintenance of intracellular osmotic pressure, in the processes of transmission and transmission to the innervated organs of the nerve impulse, in the reduction of skeletal muscles and in a number of biochemical processes. Reduces the excitability and conductance of the myocardium, in high doses - oppressing automatism.

    Calcium chloride replenishes the deficiency of calcium ions necessary for the process of transmission of nerve impulses, the reduction of skeletal and smooth muscles, myocardial activity, the formation of bone tissue, and the coagulation of blood. Reduces the permeability of cells and the vascular wall, prevents the development of inflammatory reactions,increases the resistance of the body to infections and can significantly enhance phagocytosis (phagocytosis, which decreases after intake of sodium chloride, increases after intake of calcium ions). Stimulates the sympathetic department of the autonomic nervous system, enhances the secretion of epinephrine by the adrenal glands, and has a moderate diuretic effect.

    Magnesium chloride. Magnesium participates in many processes occurring in the body - in the production of energy, the assimilation of glucose, the transmission of the nerve signal, the synthesis of proteins, the construction of bone tissue; regulation of relaxation and tension of blood vessels and muscles. It has a calming effect, reducing the excitability of the nervous system and strengthening the processes of inhibition in the cerebral cortex, acts as an anti-allergic and anti-inflammatory factor, protects the body from infection, participating in the production of antibodies, plays a significant role in the processes of blood coagulation, regulation of the bowel, bladder and prostate cancer.

    Sodium bicarbonate - a means for restoring the acid-base state of blood and correcting metabolic acidosis.In the dissociation of sodium bicarbonate, a bicarbonate anion that binds hydrogen ions to form a carboxylic acid is released, which then decomposes into water and exhaled carbon dioxide. As a result, the pH of the blood shifts to the alkaline side, the buffer capacity of the blood increases.

    Sodium chloride - plazmozameschayuschee means, has detoxification and rehydration effect; normalizes the acid-base state. Replenishes sodium deficiency with various pathological conditions of the body, sodium chloride is contained in the blood plasma and body fluids (concentration about 0.9%).

    Pharmacokinetics:

    Povidone does not undergo metabolic changes in the body. Quickly excreted by the kidneys, within 4 hours 80% are output, and after 12-24 hours - completely.

    Potassium chloride after administration, it is easily and practically in any amount passively absorbed (70%), because its concentration, released from the dosage form, is higher in the lumen of the small intestine than in the blood. In the ileum and large intestine, potassium is released into the lumen of the gut by the principle of conjugated metabolism with sodium and is secreted with bile (10%). T1/2 in the absorption phase is 1.31 hours.

    Calcium chloride is excreted from the body through the intestines and kidneys. Absorption of calcium occurs in the small intestine, mainly in the duodenum. Here, bile acids form complex compounds with calcium salts, which then pass through the wall of the villi.

    Magnesium chloride is normally excreted in 80% in 24 hours. In kidneys it is filtered in the glomeruli, and then reabsorbed in the thick section of the ascending knee of the nephron loop. Magnesium reabsorption is associated with the kinetics of calcium and sodium: with the intensification of natriuresis and calcium sulphide, excretion and magnesium increase. Therefore, any infusion of solutions containing these cations increases the excretion in urine and magnesium.

    Sodium bicarbonate increases the excretion of sodium and chlorine ions from the body, increases osmotic diuresis, alkalinizes urine, preventing precipitation of uric acid salts in the urinary system. Inside the cells, the bicarbonate anion does not penetrate.

    Sodium chloride, being the most important inorganic component supporting the corresponding osmotic pressure of blood plasma and extracellular fluid, is rapidly eliminated from the vascular bed,only temporarily increasing the volume of circulating blood (effectiveness with blood loss and shock is insufficient).

    Indications:

    Detoxification therapy with:

    - Toxic forms of acute infectious intestinal diseases (shigellosis, salmonellosis);

    - peritonitis (in the postoperative period);

    - liver disease, accompanied by the development of liver failure;

    - burn disease;

    acute radiation sickness;

    - sepsis;

    - hemolytic disease of newborns;

    - intrauterine infection and toxemia of newborns.

    Contraindications:

    Hypersensitivity to the components of the drug, intracranial hypertension, hemorrhagic stroke, post-traumatic brain injury, chronic heart failure of NYHA functional class II-IV, respiratory failure, severe allergic reactions, thromboembolism, oliguria, anuria, acute nephritis, bronchial asthma, phlebothrombosis, lactation period.

    Carefully:

    Pregnancy.

    Pregnancy and lactation:

    Use during pregnancy is allowed if the potential benefit to the mother exceeds the possible risk to the fetus.

    During breastfeeding it is necessary to stop breastfeeding.

    Dosing and Administration:

    The drug is injected intravenously at a rate of 40-80 drops / min.

    A single dose depends on the age of the patient and the severity of intoxication.

    The initial dose for infants is 2.5 ml / kg body weight. Infants are given no more than 14-16 drops per minute; course - 5-7 days.

    The maximum single dose, depending on the age of the patient is presented in the table:

    Patient's age

    Maximum single dose

    Up to 1 year

    50 ml

    2-5 years

    70 ml

    6-9 years

    100 ml

    10-15 years

    200 ml

    adults

    400 ml

    The number of injections and the total amount of the drug administered depend on the nature and course of the pathological process. Solutions are injected warmed to 38-40 ° C at a rate of 40-48 ml per minute.

    In acute gastrointestinal diseases and intoxication, with burn and acute radiation sickness during the phase of intoxication, usually 1-2 infusions are administered, with hemolytic disease and toxemia of newborns 2-8 times a day (daily or every other day); for 1-10 days, depending on the severity of intoxication.

    Side effects:

    With a slow administration, it usually does not cause complications. Introduction with increased speed causes lowering of arterial pressure, tachycardia, difficulty breathing and the need for vasoconstrictive and cardiac agents, calcium chloride.

    Individual patients may experience allergic reactions of varying severity (up to the development of anaphylactic shock). In these cases, it is necessary to immediately stop the infusion, conduct symptomatic therapy (to introduce antihistamines, cardiotonic, vasopressor drugs, glucocorticoids).

    Infection at the injection site, thrombosis or phlebitis, spreading from the site of infusion.

    Overdose:

    In case of an overdose, the drug should be withdrawn and symptomatic therapy should be performed.

    Interaction:

    With extensive burns combined with the introduction of plasma, albumin, gamma globulin.

    It can be used in combination with colloidal solutions (dextran, gelatin, etc.); is also compatible with blood products.

    Special instructions:

    Before administration, the solution is warmed to body temperature.

    Before the start of the infusion, it is necessary to check the shelf life of the drug.

    The drug should be clear, free of sediment, sediment and mold.

    Pressing on the package with the drug is checked for its tightness and integrity. The results of visual inspection are recorded in the medical history.

    During the treatment, it is necessary to monitor blood pressure and condition.

    Effect on the ability to drive transp. cf. and fur:

    Data are not available due to the exclusive use of the drug in a hospital setting.

    Form release / dosage:Solution for infusion.
    Packaging:

    100, 200, 400 ml in glass bottles for blood, infusion and transfusion preparations with a capacity of 100, 250 and 450 ml respectively, sealed with rubber stoppers and crimped with aluminum caps.

    Each bottle, together with instructions for use, is placed in a pack of cardboard.

    35 bottles with a capacity of 100 ml, 24, 28

    bottles with a capacity of 250 ml and 12, 15 bottles with a capacity of 450 ml, respectively, are placed in boxes of cardboard corrugated with an enclosed instructions for use in an amount corresponding to the number of bottles (for hospitals).

    100, 200, 250, 400, 500, 1000 ml into bags of polyolefin film.

    56 bags of 100 ml, 24, 28 packs of 200 ml or 250 ml and 12, 15 packs of 400 ml or 500 ml, 12 packets of 1000 ml are placed in boxes of cardboard corrugated together with instructions for use in an amount corresponding to the number of packages (for hospitals).

    Storage conditions:At a temperature of 0 to 20 ° C.
    Keep out of the reach of children.
    Shelf life:

    3 years.

    Do not use after the date shown on the package.

    Terms of leave from pharmacies:On prescription
    Registration number:LS-001636
    Date of registration:10.04.2012 / 18.05.2016
    Expiration Date:Unlimited
    The owner of the registration certificate:Promomed Rus, Open CompanyPromomed Rus, Open Company Russia
    Manufacturer: & nbsp
    Representation: & nbspBIOCHEMICAL JSC BIOCHEMICAL JSC Russia
    Information update date: & nbsp21.03.2017
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