Hepa-Mertz (Hepa-Merz)

Composition Pharmacodynamics Indications Carefully Contraindications Dosing and Administration Side effects Form release / dosage
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Active substanceOrnithineOrnithine
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    • Dosage form: & nbspconcentrate for solution for infusion
    Composition:

    1 ampoule contains 5 grams L-ornithine-Laspartate, water for injection up to 10 ml.

    Description:

    A clear solution of light yellow color.

    Pharmacotherapeutic group:Hypoazotemic means
    ATX: & nbsp

    A.05.B.A.06   Ornithine oxoglurate

    Pharmacodynamics:

    Reduces the elevated level of ammonia in the body, in particular, with liver diseases. The effect of the drug is associated with its participation in the ornithine cycle of urea formation Krebs (formation of urea from ammonia). It promotes the production of insulin and growth hormone. Improves protein metabolism in diseases requiring parenteral nutrition.

    Pharmacokinetics:It is excreted by the kidneys.

    Indications:

    Acute and chronic liver disease, accompanied by hyperammonemia. Hepatic encephalopathy incl.in the complex therapy of mental disorders (precoma and coma).

    As a corrective additive to preparations for parenteral nutrition in patients with protein deficiency.

    Contraindications:

    Severe renal failure with a creatinine score greater than 3 mg / 100 ml. Hypersensitivity to the drug components, lactation period.


    Carefully:Pregnancy.
    Pregnancy and lactation:With caution in pregnancy. Contraindicated during lactation
    Dosing and Administration:

    Intravenously inject up to 4 ampoules per day, dissolving the contents of the ampoules in 500 ml of the infusion solution. In hepatic encephalopathy, depending on the severity of the condition, up to 8 ampoules per day is administered. Duration of infusion, frequency and duration of treatment are determined individually.

    The maximum rate of intravenous administration is 5 g per hour.

    Do not dissolve more than 6 ampoules in 500 ml of the infusion solution!

    Side effects:

    Allergic reactions, in some cases, nausea and vomiting are possible.

    Overdose:

    Symptoms: increased severity of side effects.

    Interaction:Not described.
    Special instructions:

    When diagnosing hepatic encephalopathy due to the underlying disease, care must be taken when driving vehicles and engaging in other potentially dangerous activities that require an increased concentration of attention and speed of psychomotor reactions.

    If nausea or vomiting occurs, the rate of administration should be reduced.
    Form release / dosage:

    Concentrate for cooking solution for infusions, 500 mg / ml.

    Packaging:For 10 ml in ampoules of dark glass type I, DAB 10 with two colored marking rings and a white dot. 10 ampoules with instructions for use in a cardboard box with a cardboard insert for fixing ampoules.
    Storage conditions:

    At a temperature of no higher than 25 ° C.

    In a place inaccessible to children.

    Shelf life:

    3 years. Do not use after the expiration date.

    Terms of leave from pharmacies:On prescription
    Registration number:П N015093 / 02
    Date of registration:22.03.2007
    Expiration Date:Unlimited
    The owner of the registration certificate:Merz Pharma GmbH & Co. KG. KGaAMerz Pharma GmbH & Co. KG. KGaA Germany
    Manufacturer: & nbsp
    Representation: & nbspMERZ PHARMA LLCMERZ PHARMA LLCRussia
    Information update date: & nbsp24.03.2017
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