Active substanceOrnithineOrnithine Similar drugsTo uncover Hepa-Mertz granules inwards Merz Pharma GmbH & Co. KG. KGaA Germany Hepa-Mertz concentrate d / infusion Merz Pharma GmbH & Co. KG. KGaA Germany Larnamine concentrate d / infusion FARMAK, JSC Ukraine OrnilaTex® concentrate d / infusion FarmSirma Soteks, ZAO Russia Ornithine granules inwards OBOLENSKOE PHARMACEUTICAL ENTERPRISE, CJSC Russia Ornithine canon granules inwards CANONFARMA PRODUCTION, CJSC Russia Dosage form: & nbspGranules for solution for oral administration Composition:5 g of granules containActive substance: L-ornithine-L-aspartate 3 g.Excipients: acid citric anhydrous 0.55 g flavor lemon 0,12 g flavoring orange 0.2 g sodium saccharinate (saccharin sodium) 0.0045 g sodium cyclomate 0.0405 g dye sunset yellow 0.0005 g polyvinylpyrrolidone (povidone) 0.05 g of fructose (levulose) 1.1345 g Description:A mixture of orange and white granules. Pharmacotherapeutic group:Preparations for the treatment of liver diseases ATX: & nbspA.05.B.A.06 Ornithine oxoglurate Pharmacodynamics:Has a detoxification effect, reducing the elevated level of ammonia in the body, in particular, with liver diseases. The effect of the drug is associated with its participation in the ornithine cycle of urea formation Krebs (activates the cycle, restoring the activity of liver enzymes: ornithine-carbamoyltransferase and carbamoyl-phosphate synthetase).Promotes the production of insulin and growth hormone. Improves protein metabolism in diseases requiring parenteral nutrition. Helps reduce asthenic, dyspeptic and pain syndromes, as well as normalization of increased body weight (with steatosis and steatohepatitis). Pharmacokinetics:L-ornithine-L-aspartate rapidly dissociates into ornithine and aspartate, and begins to act for 15-25 minutes, with a short half-life. It is excreted in the urine through a cycle of urea formation. Indications:Acute and chronic liver disease, accompanied by hyperammonemia. Hepatic encephalopathy (latent and pronounced). Steatoses and steatohepatitis (of various origins). Contraindications:Severe renal failure with a creatinine score greater than 3 mg / 100 ml, hypersensitivity to the drug components, lactation period, children's age (due to insufficient data). Carefully:Pregnancy. Pregnancy and lactation:contraindicated in lactation, gently in pregnancy Dosing and Administration:Inside for 1-2 packets of granules dissolved in 200 ml of liquid, 3 times a day after meals. The course of admission depends on the severity of the disease. Side effects:From the gastrointestinal tract: infrequently: nausea, vomiting, abdominal pain, flatulence, diarrhea.From the side of the musculoskeletal and connective tissue: very rarely: pain in the limbs.Dye sunset sunset yellow can cause allergic reactions. Overdose:Symptoms: increased severity of side effects. Treatment: gastric lavage, reception of activated charcoal, symptomatic therapy. Special instructions:When diagnosing hepatic encephalopathy due to the underlying disease, care must be taken when driving vehicles and engaging in other potentially dangerous activities that require an increased concentration of attention and speed of psychomotor reactions. Form release / dosage:Granules for solution for oral administration, 3 g. Packaging:For 10 or 30 bags (5 g) of granules for the preparation of a solution for oral administration containing 3 g L- ornithine-Laspartate, packed in a cardboard box with instructions for use. Storage conditions:At a temperature of no higher than 25 ° C. In a place inaccessible to children. Shelf life:5 years. Do not use after the expiration date. Terms of leave from pharmacies:Without recipe Registration number:П N015093 / 01 Date of registration:22.03.2007 Expiration Date:02.09.2016 The owner of the registration certificate:Merz Pharma GmbH & Co. KG. KGaAMerz Pharma GmbH & Co. KG. KGaA Germany Manufacturer: & nbspMERZ PHARMA GmbH & Co., KGaA Germany Representation: & nbspMERZ PHARMA LLCMERZ PHARMA LLCRussia Information update date: & nbsp24.03.2017 Illustrated instructions × Illustrated instructions Instructions