Glutamic acid (Glutaminic acid)

Composition Pharmacodynamics Indications Carefully Contraindications Dosing and Administration Side effects Form release / dosage
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Active substanceGlutamic acidGlutamic acid
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  • Glutamic acid
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    MARBIOFARM, OJSC     Russia
  • Glutamic acid
    pills inwards 
    TATHIMFARMPREPARATY, JSC     Russia
    • Dosage form: & nbspenteric coated tablets
    Composition:

    Each tablet contains:

    glutamic acid (L-glutamic acid) 250 mg;

    Excipients: potato starch, talc, calcium stearate, gelatin, acetylphthalic cellulose (cellacephate).

    Description:

    Round, biconvex tablets, coated with enteric coating, white or white with a barely noticeable yellowish hue of color.

    Pharmacotherapeutic group:Nootropic remedy
    ATX: & nbsp

    N.06.B.X   Other psychostimulants and nootropic drugs

    A.16.A.A   Amino acids and their derivatives

    Pharmacodynamics:

    A remedy that regulates metabolic processes in the central nervous system; has nootropic, detoxifying, binding ammonia act. A replaceable amino acid, which plays the role of a neurotransmitter with high metabolic activity in the brain, stimulates the redox processes in the brain, the exchange of proteins. Normalizes the metabolism, changing the functional state of the nervous and endocrine systems.Stimulates the transmission of excitation in the synapses of the central nervous system; connects and displays ammonia. It is one of the components of myofibrils, participates in the synthesis of other amino acids, acetylcholine, adenosine triphosphate, urea, promotes the transfer and maintenance of the necessary concentration of potassium ions in the brain, prevents the reduction of redox potential, increases the body's resistance to hypoxia, serves as a link between the metabolism of carbohydrates and nucleic acids acids, normalizes the content of glycolysis in the blood and tissues; has a hepatoprotective effect, inhibits the secretory function of the stomach.

    Pharmacokinetics:
    Absorption is high. It penetrates well through histotematic barriers (including through the blood-brain barrier), cell membranes and membranes of subcellular formations. It accumulates in the muscle and nervous tissues, liver and kidneys. It is excreted by the kidneys - 4-7% unchanged.
    Indications:

    In adults, Glutamic acid is prescribed in complex therapy for the treatment of epilepsy, mainly small seizures with equivalents; somatogenic, involutional, intoxicating psychoses, reactive states with the phenomena of depression, exhaustion.

    In complex therapy for delayed mental development in children, Down's disease, cerebral palsy; poliomyelitis (acute and recovery periods); with progressive myopathy (in combination with pakhikarpine hydroiodide or glycine): to eliminate and prevent neurotoxic effects caused by drugs - derivatives of hydrazide isonicotinic acid.

    Contraindications:Hypersensitivity to the components of the drug, febrile syndrome, hepatic and / or renal failure, gastric ulcer and duodenal ulcer, anemia, leukopenia, increased excitability, violent psychotic reactions, nephrotic syndrome, oppression of bone marrow hematopoiesis, obesity, children under 3 -years old.
    Pregnancy and lactation:

    Adequate and controlled clinical studies of safety of the drug during pregnancy were not conducted. The application is indicated only in cases where the intended use for the mother exceeds the potential risk to the fetus.

    During the treatment period, it is necessary to resolve the issue of stopping breastfeeding.

    Dosing and Administration:

    The drug is prescribed by mouth 15-20 minutes before meals.

    Adults take in a single dose of 1 g 2-3 times a day.

    Children aged 3-4 years - 0.25 g, 5-6 years old - 0.5 g, 7-9 years - 0.5-1 g, at the age of 10 years and over - 1 g 2-3 times a day.

    The course of treatment is 1-2 to 6-12 months.

    Side effects:

    There may be allergic reactions, nausea, vomiting, abdominal pain, diarrhea, increased excitability.

    With prolonged use - lowering the level of hemoglobin and development of leukopenia, irritation of the mucous membrane of the mouth, cracks in the lips.

    Overdose:
    Overdose Glutamic acid may be accompanied by pain in the stomach, nausea, vomiting. The first help consists in washing the stomach, taking activated charcoal. If necessary, symptomatic therapy.

    Interaction:

    In combination with thiamine and pyridoxine, the drug is used to prevent and treat neurotoxic events caused by drugs of the isonicotinic acid hydrazide group (isoniazid, flvivazide and etc.).

    With myopathy and muscular dystrophy, the drug is more effective in combination with pachycarpine hydroiodide or glycine.

    Special instructions:

    During the period of treatment, it is necessary to conduct general clinical tests of blood and urine.

    With the development of dyspepsia, the drug is taken during or after a meal.

    Form release / dosage:

    Intestine-soluble film coated tablets, 250 mg.

    Packaging:

    10 tablets per contour cell pack.

    2 or 4 contour mesh packages together with the instruction for use are placed in a cardboard pack.

    It is allowed to use contour packagings together with an equal number of instructions for use in boxes made of corrugated cardboard.
    Storage conditions:

    In a dry place at a temperature of no higher than 25 ° C.

    Keep out of the reach of children.

    Shelf life:

    3 of the year.

    Do not use after the expiry date printed on the package.

    Terms of leave from pharmacies:Without recipe
    Registration number:P N003127 / 01
    Date of registration:24.11.2008
    Expiration Date:Unlimited
    The owner of the registration certificate:TATHIMFARMPREPARATY, JSC TATHIMFARMPREPARATY, JSC Russia
    Manufacturer: & nbsp
    Representation: & nbspTATHIMFARM PREPARATIONS OJSC TATHIMFARM PREPARATIONS OJSC Russia
    Information update date: & nbsp23.04.2017
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