Glutamyl-Cysteinyl-Glycine disodium - instructions for use, dose, side effects, contraindications

Clinical and pharmacological group: & nbsp

Immunomodulators

Included in the formulation

Glutoxim®

solution for injections

PHARMA VAM, CJSC Russia

Glutoxim®

powder

PHARMA VAM, CJSC Russia

Included in the list (Order of the Government of the Russian Federation No. 2782-r of 30.12.2014):

VED

АТХ:

L.03.A.X Other immunostimulants

Pharmacodynamics:

Enhances the processes of thiol metabolism inside cells. Sets a new level of redox potential of cells, accelerates the processes of phosphorylation of proteins that make signal-transfer systems and transcription factors of immunocompetent cells. Stimulates the differentiation of normal and proliferation of transformed cells.

Selectively interacts with cells of the immune system and lymphoid tissue, accelerates the process of lymphopoiesis, erythropoiesis, granulocyte monocytopoiesis. Activates the reaction of phagocytosis in conditions of immunodeficiency.

Pharmacokinetics:

After intravenous administration, the maximum concentration in the blood plasma is reached after 2-5 minutes, after 7-10 minutes - after intramuscular injection.

It accumulates in the parenchymal organs and lymphoid tissue. Metabolized to amino acids.

Elimination by the kidneys in the form of metabolites.

Indications:

It is used to treat secondary immunodeficiency conditions caused by exposure to radiation, chemical, infectious factors. It is used to restore bone marrow circulation.It is used to improve immunity in ARVI, viral hepatitis, autoimmune diseases, pulmonary tuberculosis, sepsis. With the preventive purpose it is used after surgical interventions, and also with the purpose of strengthening antibacterial therapy.

ICD-10

I.A15-A19.A15 Tuberculosis of respiratory organs, confirmed bacteriologically and histologically

I.A15-A19.A18 Tuberculosis of other organs

I.B15-B19.B18.2 Chronic viral hepatitis C

I.B15-B19.B18.1 Chronic viral hepatitis B without delta-agent

III.D60-D64.D61 Other aplastic anemia

III.D60-D64.D63 * Anemia in chronic diseases classified elsewhere

X.J40-J47.J44 Other chronic obstructive pulmonary disease

XI.K70-K77.K71 Toxic liver disease

XI.K70-K77.K73 Chronic hepatitis, not elsewhere classified

XII.L40-L45.L40 Psoriasis

XIII.M05-M14.M07 * Psoriatic and enteropathic arthropathies

XIX.T79.T79.3 Post-traumatic wound infection, not elsewhere classified

XX.Y83-Y84.Y84.2 Radiological procedure and radiation therapy

XXI.Z20-Z29.Z29.8 Other specified preventive measures

XXI.Z40-Z54.Z51.8 Other specified type of medical care

Contraindications:

Pregnancy and lactation, age under 18 years, individual intolerance.

Carefully:

Severe hepatic and renal insufficiency.

Pregnancy and lactation:

Recommendations for FDA - Category C. Contraindicated in pregnancy and lactation.

Dosing and Administration:

Intravenously, intramuscularly, 5-40 mg daily. The course of treatment is 10 days. With a preventive purpose - 5-10 mg per day.

The highest daily dose: 40 mg.

The highest single dose: 40 mg.

Side effects:

Soreness in the injection site, subfebrile condition.

Allergic reactions.

Overdose:

Cases of overdose are not described.

Treatment is symptomatic.

Interaction:

Strengthens the effects of rifampicin, isoniazid, rifabutin, capreomycin, cycloserine, levofloxacin against mycobacteria tuberculosis.

Reduces the effects of verapamil and nifedipine.

Indomethacin and meloxicam inhibit the action of the drug.

Special instructions:

With intramuscular or subcutaneous injection, it is recommended to administer 1-2% procaine solution.

Instructions

Glutamyl-Cysteinyl-Glycine Disodium (Glutamyl-Cysteinyl-Glycinum dinatrium)