Meloksikam - instructions for use, doses, side effects, contraindications

The relatively selective inhibition of cyclooxygenase-2, leading to a reduction in the synthesis of prostaglandins. Has anti-inflammatory, analgesic and antipyretic effect.

Pharmacokinetics:

Well absorbed from the digestive tract, absolute bioavailability - 89%, simultaneous intake of food does not change the absorption. When using the drug inside at doses of 7.5 and 15 mg, its concentrations are proportional to the doses. Relationship with plasma proteins 99%. Biotransformation in the liver (CYP2S9) with the formation of inactive metabolites. Half-life 15-20 hours. It is excreted by the kidneys 20% (in the form of metabolites), with feces 20%, unchanged - only 1.6%.

Indications:

ATinflammatory and degenerative diseases of joints with pain syndrome:

- Arthritis (including rheumatoid, acute osteoarthritis, chronic polyarthritis);

- ankylosing spondylitis (Bekhterev's disease);

- pain syndrome in osteoarthrosis and radiculitis.

ICD-10

XIII.M05-M14.M05 Seropositive rheumatoid arthritis

XIII.M20-M25.M25.5 Pain in the joint

XIII.M15-M19.M15 Polyarthrosis

XIII.M45-M49.M45 Ankylosing spondylitis

Contraindications:

- individual intolerance;

- "Aspirin triad" (complete or incomplete combination of bronchial asthma, recurrent nasal polyposis and paranasal sinuses and intolerance to acetylsalicylic acid and pyrazolone preparations);

- bronchial asthma;

- erozivno-ulcerative lesions of the gastrointestinal tract in the phase of exacerbation;

- severe hepatic impairment;

- chronic renal failure;

- pregnancy and breastfeeding;

- children under 12 years.

Carefully:

Elderly age.

For rectal administration - inflammatory diseases of the rectum and anal, rectal or anal bleeding.

Pregnancy and lactation:

Recommendations FDA category C. Do not use during pregnancy and during breastfeeding.

Dosing and Administration:

The drug is taken orally during a meal or injected intramuscularly in a daily dose of 7.5-15 mg.

Side effects:

Digestive system: dyspepsia, nausea, vomiting, abdominal pain, stool disorders (constipation or diarrhea), bloating, stomatitis, transient changes in liver function indicators (increased transaminase or bilirubin level), belching, esophagitis, stomach and duodenal ulcer, latent or macroscopically visible gastrointestinal bleeding, in very rare cases - gastrointestinal perforation, colitis, gastritis.

Nervous system: headache and dizziness, vertigo, drowsiness, noise in the ears.

Sense organs: conjunctivitis, impaired vision.

Blood: anemia, leukopenia, thrombocytopenia.

The cardiovascular system: rise blood pressure, palpitation, flushes of blood to the face.

Respiratory system: exacerbation of bronchial asthma, cough.

Genitourinary system: rarely - acute renal failure, interstitial nephritis, glomerulonephritis, renal medullary necrosis, nephrotic syndrome.

Leather: skin rash, itching, hives, in rare cases - photosensitivity, bullous reactions, erythema multiforme, Stevens-Johnson syndrome, toxic epidermal necrolysis.

Allergy: angioedema, immediate-type hypersensitivity reactions, including anaphylactic and anaphylactoid.

Others: bronchospasm, fever.

Overdose:

Overdose develops anaphylactoid reaction, cardiac arrest, seizures, drowsiness, lethargy, epigastric pain, gastrointestinal bleeding, liver dysfunction, hypertension, respiratory depression, nausea, vomiting, acute renal failure. Treatment is symptomatic.

Interaction:

Anticoagulants of direct and indirect action when used together with the drug may cause an increased risk of bleeding of different locations.

Acetylsalicylic acid in combination with meloxicam leads to an increased risk of gastrointestinal ulcers and other complications of the gastrointestinal tract.

ACE inhibitors with simultaneous application cause an increase in the hypotensive effect, an increased risk of developing kidney failure, and lithium salts lead to an increase in the concentration of lithium ions in the blood.

Special instructions:

The use of meloxicam can cause the occurrence of such undesirable effects as headache and dizziness, drowsiness. In this regard, it is necessary to abandon the management of vehicles, maintenance of machinery and mechanisms and other activities requiring increased concentration of attention.

Instructions

Meloksikam (Meloxicamum)