The vaccine is administered intranasally, twice with an interval of 10 days. Immediately before vaccination, the contents of the ampoule are dissolved at room temperature in an appropriate volume of solvent (0.5 ml, 1.0 ml, 15 ml or 3.0 ml for the vaccine at 1, 2, 3 doses or 6 doses, respectively). The vaccine should be completely dissolved within 3 minutes.
Dissolved drug - a clear or slightly opalescent liquid. Dissolved vaccine should be used within 30 minutes.
It is not suitable to use the drug in ampoules with broken integrity, marking, as well as changing its physical properties (color, transparency), with improper storage.
The vaccine is injected into the nasal passages at a rate of 0.25 ml per each nasal opening.
To administer the vaccine in the form of a finely dispersed mixture, a dispenser is used - a dispenser consisting of a sterile syringe, a sterile needle and one disposable disposable nozzle included in the vaccine kit.
Spray dispenser (removable nozzle) is injected at a depth of 0.5 cm into the nasal passages, previously cleaned of mucus. The grafted should be sitting in a sitting position with a slightly upturned head.After vaccine administration, the vaccine should remain in this position for 1 min.
Mode of application:
1. Put the needle on the syringe, fill it with a solvent (water purified or water boiled room temperature).
2. Add the solvent (0.5, 1.0, 1.5 or 3.0 ml according to the vaccine form) to the opened ampoule with the vaccine from the syringe.
3. After dissolving, fill the syringe with the drug in a volume of 0.25 ml (a mark of 10 on a scale of 40 units or a mark of 25 on a scale of 100 units).
4. Remove the needle and put on a tightly detachable nozzle.
5. Bring the nebulizer dispenser close to the nasal passage and squeeze the vaccine into the nasal passage with a sharp push on the syringe plunger.
6. Remove the dispenser dispenser, put on the needle and fill the syringe with the next dose of the drug (0.25 ml).
7. Remove the needle, re-tighten the same dispenser and inject the drug into the other nasal passage in accordance with paragraph 5.
For the subsequent vaccinations (the form of release more than 1 dose in an ampoule), repeat the actions described in p. 3-7, with the mandatory replacement of the removable attachment for each subsequent vaccine.
Precautionary measures. The graft is recommended to be isolated within 3 days from children of the first half of life and from individuals with a primary and severe secondary immunodeficiency state.