Ismigen® (Ismigen®)

Composition Pharmacodynamics Indications Carefully Contraindications Dosing and Administration Side effects Form release / dosage
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Active substanceLysates of bacteria [Staphylococcus aureus, Streptococcus pyogenes, Streptococcus viridans, Streptococcus pneumoniae, Klebsiella pneumoniae, Klebsiella ozaenae, Haemophilus influenzae B, Neisseria catarrhalis]Lysates of bacteria [Staphylococcus aureus, Streptococcus pyogenes, Streptococcus viridans, Streptococcus pneumoniae, Klebsiella pneumoniae, Klebsiella ozaenae, Haemophilus influenzae B, Neisseria catarrhalis]
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  • Ismigen®
    pills n / az. 
    NIZHFARM, JSC     Russia
    • Dosage form: & nbspsublingual tablets
    Composition:

    Composition per one tablet:

    Lyophilized bacterial lysates - 50 mg, including Active ingredient: bacterial lysates Staphylococcus aureus, Streptococcus pyogenes, Streptococcus viridans, Streptococcus pneumoniae (types - TY1 ​​/ EQ11, TY2 / EQ22, TY3 / EQ14, TY5 / EQ15, TY8 / EQ23, TY47 / EQ 24), Klebsiella pneumoniae, Klebsiella ozaenae, Haemophilus influenzae b, Neisseria catarrhalis - 7.0 mg; adjuvant: glycine - 43 mg. Excipients - microcrystalline cellulose 150.0 mg, calcium hydrophosphate dihydrate 35.0 mg, silicon colloidal dioxide 10.0 mg, magnesium stearate 3.0 mg, ammonium glycyrrhizinate 1.2 mg, peppermint flavor 0.8 mg.

    Description:

    Tablets are flat-cylindrical with a risk, light cream color with brown impregnations and a weak smell of mint.

    Pharmacotherapeutic group:Immunostimulating agent
    ATX: & nbsp

    L.03.A.X   Other immunostimulants

    Pharmacodynamics:

    Combined immunostimulating drug of bacterial origin for sublingual (sublingual) administration. It is a multivalent antigenic complex, which includes lysates of bacteria - the most common pathogens of respiratory infections. Lysates, which are part of the drug Ismigen®, are obtained by mechanical destruction of bacterial cells.Ismigen® has a nonspecific immunostimulating and specific vaccinating action. Ismigen® tablets sublingual has an effect on the various links of immunity. Stimulates both local (increases concentration of secretory IgA), and systemic (cellular and humoral) immunity. Activates phagocytosis, increases the lysozyme content in saliva, promotes an increase in the number of immunocompetent cells, increases the concentration of serum IgA, IgG, IgM and reduces the concentration of whey IgE.

    Increases the functional activity of macrophages (including alveolar) and polymorphonuclear leukocytes, which contributes to the destruction of infectious agents. As a result of treatment with Ismigen®, the incidence, severity and duration of acute infections of the respiratory tract are reduced; there is relief and leveling of symptoms such as fever, cough, shortness of breath, the need for antibacterial and anti-inflammatory therapy decreases; in patients with chronic diseases of the respiratory tract, the drug also prevents exacerbations.

    Indications:

    Acute and subacute infections of the upper and lower respiratory tract: bronchitis, tonsillitis, pharyngitis, laryngitis, rhinitis, sinusitis, otitis media, including complications after the flu (treatment in combination therapy).

    Recurrent infections of the upper and lower respiratory tract, chronic bronchitis (prevention of exacerbations).

    Contraindications:

    Hypersensitivity to the active and / or auxiliary components of the drug, pregnancy, the period of breastfeeding, children under 3 years.

    Pregnancy and lactation:Contraindicated.

    Dosing and Administration:Under the tongue; take on an empty stomach. The tablet should be kept under the tongue until completely dissolved. Tablets of the sublingual should not be absorbed, chewed or swallowed.

    Acute and subacute upper and lower respiratory tract infections

    1 tablet a day until the symptoms disappear (at least 10 days).

    Recurrent infections of the upper and lower respiratory tract, prevention of exacerbations of chronic respiratory diseases

    1 tablet a day for 10 days. The preventive course includes three cycles of 10 days with 20-day intervals between them.

    Preventive course should be conducted no more than 1-2 times a year.

    If you miss a dose, you should not double it the next time you take it. If, after treatment, no improvement occurs or the symptoms worsen, or new symptoms appear, you should consult your doctor.

    Use the drug only according to the indications, the method of administration and the doses indicated in the instructions.

    Side effects:

    The incidence of side effects is classified according to the recommendations of the World Health Organization: very often - more than 10%; often - more than 1 and less than 10%; infrequently - more than 0,1 and less than 1%; rarely - more than 0.01 and less than 0.1%; very rarely - less than 0.01%.

    From the skin: very rarely - hives, dermatitis, folliculitis.

    Other: very rarely - inflammation of the salivary gland, acute laryngitis, rhinitis.

    If you have side effects indicated in the instructions, or are aggravated, or if you notice any other side effects not listed in the instructions, tell your doctor.

    Overdose:Data on cases of overdose are absent.

    Interaction:Ismigen® can be used concomitantly with other medicines intended for the treatment of acute and chronic respiratory diseases.The peculiarities of the interaction of the drug Ismigen with other medications have not been described to date.

    If you use the above or other medications (including over-the-counter drugs) before applying Ismigen® consult a doctor.

    Special instructions:Children aged 3 to 6 years at the time of taking each dose, until the tablet is completely dissolved in the oral cavity, should be under the supervision of adults.

    Effect on the ability to drive transp. cf. and fur:Does not affect.

    Form release / dosage:Tablets sublingual 7 mg.
    Packaging:10 tablets in a planar cell packaging made of a polyvinylchloride film and aluminum foil. 1 or 3 contour mesh packages together with instructions for use in a pack of cardboard.

    Storage conditions:

    Store at a temperature not exceeding 25 ° C.

    Keep out of the reach of children.

    Shelf life:

    3 years. Do not use after the expiration date printed on the package.

    Terms of leave from pharmacies:On prescription
    Registration number:LP-002210
    Date of registration:30.08.2013 / 10.04.2017
    Expiration Date:30.08.2018
    The owner of the registration certificate:NIZHFARM, JSC NIZHFARM, JSC Russia
    Manufacturer: & nbsp
    Information update date: & nbsp30.11.2017
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