Intravenously (intravenously), drip, intramuscularly (in / m), in the cavity. It is not recommended to inject intravenously the undiluted kanamycin solution, in connection with the possibility of developing a neuromuscular blockade.
With infections of non-tuberculous etiology: single dose for adults - 0.5 g, daily - 1-1.5 g (0.5 g every 8-12 h). The maximum daily dose is 2 g (1 g every 12 hours).
The course of treatment is 5-7 days, depending on the severity and features of the course of the process.
Children (only in / m). Children from 1 month to 1 year are administered in an average daily dose of 0.1 g, from 1 to 5 years - 0.3 g, over 5 years - 0.3-0.5 g.The maximum daily dose is 15 mg / kg. The daily dose is divided into 2-3 injections.
With tuberculosis the drug is used as part of complex therapy.
Enter intramuscularly: adults - 1 g once a day or 0.5 g 2 times a day, children older than 1 month - 15 mg / kg / day 6 days a week with a break for 7 days, but not more than 0, 5-0.75 g per day. The number of cycles and the total duration of treatment is determined by the stage and features of the course of the disease and is 1 month or more.
Intraperitoneal (intraperitoneal): Only adults with peritonitis and with abdominal contamination of the contents of the large intestine during surgery - 0.5 g of the drug are dissolved in 20 ml of water for injection.
In the cavity (abdominal, pleural, articular): Only adults with abscessing, postoperative infections are administered in the form of 0.25% solution (2.5 mg / ml).
The maximum daily dose is no more than 2 g, taking into account other ways of drug administration.
In renal failure, the administration regimen is adjusted by decreasing the dose taking into account the body weight or increasing the intervals between the administrations, according to the calculated formulas:
initial dose (mg) = body mass x 7;
subsequent doses (mg) = initial dose / creatinine content in blood plasma (mg /100 ml);
interval (h) = creatinine content in blood plasma (mg/100 ml) x 9.
Multiplicity of administration 2-3 times a day. In days of hemodialysis after its carrying out in addition introduce a single dose of the drug.
To avoid overdose of the drug, it is recommended to periodically monitor the concentration of antibiotic in the patient's blood.
Preparation of solutions
For intramuscular injection a single dose (0.5 g or 1 g) is dissolved in 2 ml or 4 ml of water for injection or 0.25-0.5% solution of procaine.
For intravenous drip prepared at initial dilution, a solution containing a single dose of the preparation (0.5 g) is dissolved in 200 ml of a 5% dextrose solution and injected at a rate of 60-80 cap / min.
Intraperitoneal - 0.5 g (as a 2.5% solution), for which a single dose of 0.5 g is dissolved in 20 ml of water for injection.
In the cavity (pleural, abdominal, articular) for washing, 10-50 ml of 0.25% aqueous solution is administered.
The solutions are used immediately after preparation.