Nervous system: dyskinesia, including choreoathetosis, dystonia, with prolonged use of the "on-off" syndrome, malignant neuroleptic syndrome, dizziness, ataxia, nausea, dystonic involuntary movements, convulsions, anorexia, sedation, drowsiness, confusion, nightmares, nervous tension, increased excitability, anxiety, insomnia; changes in mental status, including paranoid effects and transient psychoses; hallucinations, depression with or without development of suicidal intentions, hypomania, increased libido, euphoria, dementia. The basis for the decision to reduce the dose of the drug can serve as early symptoms, such as muscle twitches and blepharospasm.The development of seizures has been reported, but no direct connection with the use of carbidopa / levodopa has been established.
Gastrointestinal tract: anorexia, nausea, vomiting, constipation, epigastric pain, dysphagia, darkening of saliva, ulcerogenic effect in predisposed patients; rarely - gastrointestinal bleeding.
The cardiovascular system: Orthostatic hypotension, collapse, arrhythmias, tachycardia, arterial hypertension, phlebitis.
The system of hematopoiesis: rarely - leukopenia, anemia (including hemolytic), thrombocytopenia, agranulocytosis.
Allergic reactions: angioedema, urticaria, skin rash, skin itching, Shenlen-Henoch disease.
Change in laboratory indicators: changes in the level of alanine aminotransferase, aspartate aminotransferase, alkaline phosphatase, lactate dehydrogenase, urea nitrogen, bilirubin, protein bound iodine, hyperuricemia, hypercreatinemia, positive Coombs direct test.
Other: syncope, chest pain, mydriasis, diplopia, dyspnoea, darkening of secretion of sweat glands, darkening of urine, increase or decrease in body weight.
Side effects, as a rule, depend on the dose taken, as well as on the individual sensitivity of the patient. Side effects can be eliminated by a temporary dose reduction without interruption in treatment. If the side effects do not regress, then the treatment is stopped gradually.
Other side effects that have occurred with the use of LEVODOPE, which should be considered in the case of carbidopa / levodopa:
Gastrointestinal tract: dyspepsia, dry mouth, bitterness in the mouth, sialorrhea, dysphagia, bruxism, bouts of hiccough, pain and discomfort in the abdomen, constipation, flatulence, burning sensation of the tongue.
Metabolism: decreased or increased body mass, swelling. CNS: Weakness, fainting, fatigue, headache, asthenia, decreased mental activity, disorientation, ataxia, numbness, increased tremor of hands, muscle cramps, trisus, activation of latent Bernard-Horner syndrome, insomnia, anxiety, euphoria, psychomotor agitation, instability gait.
Sense organs: diplopia, blurred vision, dilated pupils, oculogic crises.
Genitourinary system: urinary retention, urinary incontinence, priapism.
Other side effects: hoarseness of voice, malaise, "hot flashes" of blood to the skin of the face, neck and chest, dyspnoea, malignant melanoma. There was reported a decrease in hemoglobin and hematocrit, hyperglycemia, leukocytosis, bacteriuria, erythrocyturia.
Change in laboratory indicators: drugs containing carbondopy-levodopa can cause a false positive reaction to ketone bodies in the urine if test strips are used to determine ketonuria. This reaction will not change after boiling urine samples. False negative results can be obtained by using a glucose oxidase method for determining glucosuria.