From the central nervous system: very often - dizziness, headache (usually not strong and arising at the beginning of treatment), weakness, fatigue, depression, paresthesia, sleep disorders, asthenia, mood lability.
From the side of the cardiovascular system: often bradycardia, orthostatic hypotension, atrioventricular blockade of II-III degree, progression of heart failure (during the period of increasing doses), edema (including generalized, edema of the lower extremities, hypervolemia, fluid retention), angina, marked decrease in blood pressure, syncopal conditions (including presyncopal), rarely - violations of peripheral circulation (cold extremities, exacerbation of the syndrome of "intermittent" lameness and Raynaud's syndrome).
From the side of the digestive tract: dryness of the oral mucosa, nausea, diarrhea or constipation, vomiting, abdominal pain.
Laboratory indicators: increased activity of "hepatic" transaminases - alanine aminotransferase (ALT), aspartate aminotransferase (ACT) and gamma-glutamyltransferase, thrombocytopenia and leukopenia.
On the part of the hematopoiesis system: rarely - thrombocytopenia, leukopenia.
From the side of metabolism: weight gain, hypercholesterolemia; in patients with existing diabetes - hyperglycemia or hypoglycemia, violations of glycemic control.
From the skin: skin reactions (skin rash, dermatitis, urticaria and skin itching), isolated cases of allergic reactions.
From the respiratory system: often - shortness of breath and bronchospasm (in predisposed patients), rarely - nasal congestion.
Other: visual impairment, decreased tear and eye irritation, flu-like syndrome, sneezing, rarely - urination disorder, renal failure and renal dysfunction in patients with diffuse vasculitis and / or renal dysfunction; very rarely - exacerbation of psoriasis, pain in the limbs, infrequent - a decrease in potency; rare cases of urinary incontinence in women; the presence of beta-adrenergic blocking properties does not exclude the possibility of manifestation of latent diabetes mellitus, decompensation of already existing diabetes mellitus or oppression of the contrinular system.