Included in the formulation
АТХ:A.01.A.B.03 Chlorhexidine
Pharmacodynamics:Combined means.
Chlorhexidine
Nonspecifically binds to phospholipids of the bacterial cell wall, inactivates ATPase and dehydrogenase, breaks the permeability of the membrane for potassium, amino acids and nucleotides.
It is active against gram-positive microorganisms: Escherichia coli, Selenomonas, Streptococcus salivarius, Streptococcus mutans, anaerobes and fungi of the genus Candida albicans, to a lesser extent - for gram-negative microorganisms: Pseudomonas, Proteus, Streptococcus sanguinis, Klebsiella spp., Veillonella species.
Ascorbic acid
Antioxidant. Participates in the synthesis of intracellular collagen. Suppresses the activity of hyaluronidase, participates in the exchange of iron and glucose. Reduces swelling and inflammation of the oral mucosa, strengthens the immune response. Inactivates hyaluronidase, activating the regeneration of tissues and normalizing the permeability of capillaries. Disinfects toxins and has an antioxidant effect, catching free radicals. He takes an active part in the regulation of immune processes: enhances the formation of antibodies, phagocytic activity and the synthesis of interferon. It inhibits the release of histamine and strengthens its degeneration, suppresses the release of mediators of inflammation and allergic reactions.
Pharmacokinetics:Chlorhexidine
When resorption is released into the saliva, binds to the mucous membrane of the tongue and mouth cavity and again falls into the saliva, showing antibacterial action. When swallowed, the stomach is almost not absorbed and excreted unchanged with faeces.
Ascorbic acid
Completely absorbed from the gastrointestinal tract after ingestion. It binds to plasma proteins by 25%. Normally, the concentration of ascorbic acid in the blood: 15-20 mcg / ml. The concentration of ascorbic acid in erythrocytes and plasma is lower than in platelets and leukocytes.
Ascorbic acid is oxidized to dehydroascorbic acid, metabolized to inactive ascorbate-2-sulfate and oxalic acid, then excreted in the urine. In cases of exceeding the dose (more than 200 mg) ascorbic acid is eliminated by the kidneys in an unchanged form.
Indications:It is used for local symptomatic treatment of inflammation of the mucous membrane of the throat, tongue, larynx.
X.J00-J06.J04 Acute laryngitis and tracheitis
X.J00-J06.J02 Acute pharyngitis
X.J00-J06.J03 Acute tonsillitis
XI.K00-K14.K05 Gingivitis and periodontal disease
XI.K00-K14.K12 Stomatitis and related lesions
Contraindications:Individual intolerance, children under 12 years.
Carefully:Hypersensitivity.
Pregnancy and lactation:Recommendations for FDA - Category B. It is used during pregnancy and lactation.
Dosing and Administration:For a slow resorption after a meal - 1 tablet 4 times a day every 6 hours for 7 days. If necessary, apply 3 tablets per day for 21 days.
The highest daily dose: 5 tablets.
The highest single dose: 1 tablet.
Side effects:Chlorhexidine
Does not have a systemic effect.
Ascorbic acid
Digestive system: irritation of the mucous membrane of the gastrointestinal tract: intestinal spasm, nausea, vomiting.
Urinary system: hyperoxaluria, nephrocalcinosis, glucosuria.
Allergic reactions.
Overdose:Cases of overdose are not described.
Treatment is symptomatic.
Interaction:Clinically significant interactions are not described.
Special instructions:Within 2 hours after taking the drug, you should avoid consuming a large number of liquids and rinsing the mouth.