Holisal® (Cholisal®)

Composition Pharmacodynamics Indications Carefully Contraindications Dosing and Administration Side effects Form release / dosage
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Active substanceCholine salicylate + Cetalkonium chlorideCholine salicylate + Cetalkonium chloride
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  • Holisal®
    gel Stomat. 
    VALEANT, LLC     Russia
    • Dosage form: & nbsp
    Dental gel.

    Composition:
    1 g contains:
    Active substances:
    choline salicylate - 87.1 mg, cetalkonium chloride - 0.1 mg.
    Excipients: hyethellosis - 20.0 mg, methylparahydroxybenzoate - 1.5 mg, propyl parahydroxybenzoate - 0.8 mg, glycerol - 50.0 mg, anise of ordinary seeds oil - 1.61 mg, ethanol 96% - 390.0 mg, water - up to 1000 mg.
    Description:
    Transparent colorless homogeneous mass with the smell of anise oil.
    Pharmacotherapeutic group:NSAIDs.
    ATX: & nbsp

    A.01.A.D   Other preparations for topical use in diseases of the oral cavity

    A.01.A.D.11   Other preparations for the treatment of diseases of the oral cavity

    Pharmacodynamics:When topically applied, the main active ingredient choline salicylate quickly absorbed through the mucous membrane of the oral cavity, providing a local analgesic, anti-inflammatory and antipyretic effect. It inhibits the activity of cyclooxygenase, the function of macrophages and neutrophils, the production of interleukin-1 and inhibits the synthesis of prostaglandins. It also has antimicrobial and antifungal action (in acidic and alkaline medium). Cetalkonium chloride-antiseptic, acts on bacteria, as well as fungi and viruses.Gel ethanol-containing adhesive base provides rapid development of the effect and permanently retains active substances on the mucous membrane. Analgesic effect occurs in 2-3 minutes, while its duration is 2-8 hours.
    Pharmacokinetics:When applied to mucous membranes, it is well absorbed.
    Indications:For topical application to the oral mucosa as an analgesic and anti-inflammatory agent in the treatment of periodontal diseases, damage to the oral mucosa, diseases occurring with inflammatory reaction and pain, including:
    - stomatitis of different etiology,
    - gingivitis,
    - periodontitis
    - damage to the mucous membrane of the oral cavity when wearing dentures,
    - trauma of the oral mucosa,
    - pain with teething in children,
    - cheilitis,
    - Candidiasis of the oral mucosa,
    - small operative interventions in the oral cavity,
    - red flat lichen if localized on the mucous membrane of the mouth,
    - damage to the oral mucosa in the syndrome of Stevens-Johnson as part of complex therapy.
    Contraindications:Hypersensitivity to salicylates and other components of the drug.
    Carefully:pregnancy, lactation, children under 1 year.
    Dosing and Administration:
    Locally. Kholisal is used 2-3 times a day before meals (for analgesia) or after meals and before bedtime. A strip of gel 1 cm long for adults and 0.5 cm for children is squeezed out onto a clean finger and rubbed with light massaging movements into the affected area of ​​the oral mucosa.
    With periodontal disease, the gel is inserted into the pockets or applied as compresses, or gently rubbed into the gums 1-2 times a day.
    Side effects:Short-term light burning in the places of application of the preparation, which passes independently. Allergic reactions.
    Overdose:Cases of overdose of Holysal® were not detected.
    Interaction:When taking Holisal®, it is possible to increase the effect of other anti-inflammatory, antipyretic and analgesic agents.
    Special instructions:
    If the first signs of a side effect of the drug appear, you should immediately inform the treating doctor about it.
    Use only for topical use. Kholisal® does not contain sugar.
    Effect on the ability to drive transp. cf. and fur:The drug does not limit psychophysical activity, ability to drive vehicles and service moving mechanisms.
    Form release / dosage:
    Dental gel.

    Packaging:
    By 10 g or 15 g in aluminum tubes with a membrane and caps made of polymer material (with
    the enemy). The tube is put in a cardboard box with instructions for use.
    Storage conditions:At a temperature of no higher than 25 ° C. Do not freeze. Keep out of the reach of children.
    Shelf life:3 years. Do not use after the expiration date printed on the package.
    Terms of leave from pharmacies:Without recipe
    Registration number:П N012118 / 01
    Date of registration:24.08.2010
    The owner of the registration certificate:VALEANT, LLC VALEANT, LLC Russia
    Manufacturer: & nbsp
    Information update date: & nbsp27.09.2015
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