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Dosage form: & nbspcapsules
Composition:

1 capsule contains:

active substances: glucosamine sulfate dicalcium salt 500 mg, chondroitin sodium sulfate 250 mg, vitamin E (α-tocopherol acetate) 8 mg;

Excipients: magnesium stearate 2 mg, talc 4 mg, butylhydroxytoluene 1 mg;

composition of gelatin capsule: titanium dioxide 2,118%, methyl parahydroxybenzoate 0.8%, propyl parahydroxybenzoate 0.2%, purified water 14 to 15%, gelatin q.s. up to 100%.

Description:

Hard gelatin capsules number 1, body and cap white, the contents of capsules - white or white powder with a yellowish hue.

Pharmacotherapeutic group:tissue repair stimulant
ATX: & nbsp
  • Other drugs for the treatment of diseases of the musculoskeletal system
  • Pharmacodynamics:

    Chondrotec® Forte stimulates the regeneration (restoration) of cartilaginous tissue.

    Glucosamine sulfate and chondroitin sulfate, which are part of the drug, participate in the synthesis of connective tissue, helping to prevent cartilage destruction processes and stimulating the regeneration of cartilaginous tissue. The introduction of exogenous glucosamine sulfate enhances the production of a cartilage matrix and provides non-specific cartilage protection against chemical damage.

    Glucosamine sulfate participates in the biosynthesis of proteoglycans, hyaluronic, chondroitinsulfuric acids, which are a building material for articular membranes, intraarticular fluid and cartilaginous tissue.

    Chondroitin sulfate participates in the construction of cartilaginous tissue, serves as an additional substrate for the formation of a healthy cartilage matrix. Stimulates the formation of hyaluronone, the synthesis of proteoglycans and type II collagen. Protects hyaluronone from enzymatic cleavage (by suppressing the activity of hyaluronidase) and the damaging effect of free radicals; maintains the viscosity of the synovial fluid, stimulates mechanisms of cartilage repair and restores the activity of those enzymes that break down cartilage (elastase, hyaluronidase).

    Chondroitin sulfate helps to restore the elasticity of the joint bag, cartilage surfaces of the joints, plays the role of natural lubrication of the joint surfaces. Reduces the activity of the inflammatory process in the tissues of cartilage and joints. Reduces the need for non-steroidal anti-inflammatory drugs in patients with arthrosis.

    Glucosamine sulfate and chondroitin sulfate, when combined, have a greater effect due to synergy, compared to the individual effect of each of these components.

    Vitamin E as an antioxidant inhibits the development of free radical reactions, prevents the formation of peroxides,damaging cellular and subcellular cartilage membranes, which is important for the body in osteoarthritis.

    Pharmacokinetics:

    Glucosamine sulfate: is distributed in tissues: the highest concentration are found in the liver, kidneys and articular cartilage. About 30% of the dose is persistently persistent in bone and muscle tissue. It is excreted mainly with urine in unchanged form; in part - with feces. T1/2 - 68 h.

    Chondroitin sulfate: is metabolized by desulfurization. It is excreted in urine T1/2 - 310 min.

    Vitamin E It is absorbed from the duodenum by 50-80%. It binds to beta-lipoproteins of blood. Deposited in all organs and tissues, especially in adipose tissue, is excreted in bile (more than 90%).

    Indications:

    Osteoarthritis I-III Art. peripheral joints and spine.

    Contraindications:

    Hypersensitivity to the components of the drug, pronounced impaired kidney function, children under 15 years of age, pregnancy, lactation.

    Carefully:

    Bleeding and a tendency to bleeding, diabetes, bronchial asthma.

    Dosing and Administration:

    Inside, adults and teenagers over 15 years, before meals, drinking 1 glass of water, 2 capsules 2 times a day.The duration of treatment is 7-8 weeks. If necessary, repeat the treatment.

    Side effects:

    Rarely, gastrointestinal function disorders (epigastric pain, flatulence, diarrhea or constipation), dizziness, allergic reactions are rare.

    Overdose:

    Cases of overdose are not known.

    Interaction:

    Compatible with non-steroidal anti-inflammatory drugs, glucocorticosteroids.

    Against the background of taking the drug, the need for non-steroidal anti-inflammatory drugs decreases, the absorption of tetracyclines increases and penicillins decrease.

    It is possible to increase the effect of anticoagulants, antiplatelet agents, fibrinolytic agents.

    Effect on the ability to drive transp. cf. and fur:

    There is no information about the possible effect of the drug on the ability to drive vehicles and mechanisms.

    Form release / dosage:Capsules.
    Packaging:

    For 10 capsules in an aluminum / PVC / PVDC blister, 2 or 5 or 10 blisters each, along with instructions for use in a cardboard pack.

    Storage conditions:

    In a dry place, at a temperature of no higher than 25 ° C.

    Keep out of the reach of children.

    Shelf life:

    3 years.

    Do not use the product after the expiry date printed on the package.

    Terms of leave from pharmacies:Without recipe
    Registration number:LP-001532
    Date of registration:24.02.2012
    Date of cancellation:2017-02-24
    The owner of the registration certificate:Outline Pharma Pvt. Ltd.Outline Pharma Pvt. Ltd. India
    Manufacturer: & nbsp
    Representation: & nbspNizhpharm, JSCNizhpharm, JSCRussia
    Information update date: & nbsp11.02.2016
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