Hyaluronidase - instructions for use, dose, side effects, contraindications

Clinical and pharmacological group: & nbsp

Enzymes and antiferments

Included in the formulation

Biogial

lyophilizate locally externally

Biona, Open Company Russia

Lidase

lyophilizate locally for injections

MICROGEN FGUP Scientific and Production Association Russia

Lidase

lyophilizate locally for injections

SAMSON-MED, LLC Russia

Lidase-M

lyophilizate locally for injections

MICROGEN FGUP Scientific and Production Association Russia

АТХ:

V.03.A.X Other medications

Pharmacodynamics:

Enzyme means isolated from testes of cattle. Splits the main component of the interstitial substance of connective tissue - hyaluronic acid (mucopolysaccharide, which includes acetylglucosamine and glucuronic acid, is a cementing substance of connective tissue). Hyaluronidase causes the decomposition of hyaluronic acid to glucosamine and glucuronic acid and thereby reduces its viscosity. It increases tissue and vascular permeability, facilitates the diffusion of fluids in interstitial space. Reduces swelling of the tissue, softens and flattens the scars, increases the amount of movement in the joints, reduces contractures and prevents their formation.

Pharmacokinetics:

The effect of hyaluronidase is reversible: as the concentration decreases, the viscosity of hyaluronic acid is restored.

Duration of action for intradermal administration is up to 48 h.

Indications:

Burn, traumatic, postoperative scars; long-term healing ulcers (including radiation ulcers); Dupuytren's contracture; stiffness of the joints, joint contractures (after inflammation, trauma), osteoarthritis, ankylosing spondylitis, severe lumbar disc disease; chronic tenosynovitis, scleroderma (skin manifestations), soft tissue hematoma of surface localization; preparation for skin and plastic surgery for scarring.

Tuberculosis of the lungs with the productive nature of inflammation (as part of complex therapy to increase the concentration of antibacterial agents in the lesions).

Traumatic lesions of nerve plexuses and peripheral nerves (plexitis, neuritis).

In ophthalmology: for a more delicate scarring of affected areas of the cornea, retinopathy of various etiologies, vitreous hemorrhage.

To improve the absorption of drugs, administered subcutaneously and intramuscularly.

ICD-10

I.A15-A19.A15 Tuberculosis of respiratory organs, confirmed bacteriologically and histologically

VII.H30-H36.H36 * Retinal lesions in diseases classified elsewhere

XII.L80-L99.L91 Hypertrophic skin changes

XIII.M15-M19.M15 Polyarthrosis

XIII.M30-M36.M34 Systemic sclerosis

XIII.M45-M49.M45 Ankylosing spondylitis

XIII.M65-M68.M65 Synovitis and tenosynovitis

XIII.M70-M79.M72.0 Palmar fascial fibromatosis [Depuitrena]

XIX.T08-T14.T14.0 Superficial injury of unspecified area of the body

Contraindications:

Malignant neoplasms, acute infectious and inflammatory diseases, pulmonary hemorrhage, hemoptysis, pulmonary tuberculosis with respiratory insufficiency, fresh vitreous hemorrhage, simultaneous application of estrogens, hypersensitivity to hyaluronidase.

Carefully:

With caution should be used in combination with other medicines, as possible unpredictable increase in absorption and enhance systemic action.

Pregnancy and lactation:

Use with caution in pregnancy and lactation.

Dosing and Administration:

With parenteral administration (subcutaneously and intramuscularly), a single dose of 64 UE.

With inhalation, retrobulbar injection, as well as when administered under the conjunctive dose is set individually, depending on the indications.

Side effects:

Maybe: allergic reactions; at the injection site - pain and infiltrates.

In some cases: ventricular fibrillation.

Overdose:

There is no evidence of an overdose of hyaluronidase.

Interaction:

Hyaluronidase improves the absorption of drugs administered subcutaneously or intramuscularly, speeds up anesthesia by administering local anesthetics.

Special instructions:

The solution should not be administered through a catheter into which solutions containing cations were previously administered.

Before the start of treatment, it is advisable to conduct a test with intradermal administration of hyaluronidase.

Do not enter into areas of infectious inflammation and tumors.

Instructions

Hyaluronidase (Hyaluronidasum)