Clofelin injection 0.01% - instructions for use, dose, side effects, contraindications

Active substanceClonidineClonidine

Similar drugsTo uncover

Clophelin

drops d / eye

MOSCOW ENDOCRINE FACTORY, FSUE Russia

Clofelin injection for 0.01%

solution in / in

ORGANICS, JSC Russia

Cloppelin Tablets

pills inwards

MOSCOW ENDOCRINE FACTORY, FSUE Russia

Dosage form: & nbspSolution for intravenous administration.

Composition:

1 ml solution ofdeactivelye substance: clonidine hydrochloride (clonidine) - 0,1 mg,
SunPomogtFerrous substances: 0,1 M hydrochloric acid solution acids - up to pH, 4.0-5.5; water for injection - up to 1 ml.

Description:Transparent colorless liquid.

Pharmacotherapeutic group:central antihypertensive drug

ATX: & nbsp

Clonidine

Pharmacodynamics:Hypothecentral drug, stimulates postsynaptic alpha2-adrenergic receptors of the vasomotor center of the medulla oblongata and reduces the flow
sympathetic impulse to the vessels and the heart at the presynaptic level. At timestrum intravenously, there may be a short-term increase in blood pressure,
caused by the stimulation of postsynaptic alpha 1 adrenorecentnersectora vessels. Increases Pocular blood flow, increasing the tone of the vessels of the brain, reduces cerebral blood flow;
has a pronounced sedative action. Hypotensive eEffects when injected into a vein
manifested through 3-5 minutes, reaches a maximum in 15-20 minutes and savedtfor 4-8 hours. Duration of therapeutic effect - 6-12 h.

Pharmacokinetics:Bioavailability for long-term use - about 65 %. Connection with blood plasma proteins -
20 - 40% Easily and quickly penetrates the blood-brain barrier, placenta and gore milk. Metabolized in the liver (about 50% of the absorbed drug). It is excreted by the kidneys (40-60 %) and through the intestine (20 %). The half-life of 12-16 h, with a violation of kidney function - up to 41 hours.

Indications:

Coping of hypertensive crisis.

Contraindications:

AMr.trioMr.tikulyarnaya blockade II and III degree, pronounced sinus bradycardia, marked atherosclerotic changes in cerebral vessels, cardiogenic shock, Depression, obliterating diseases of peripheral arteries, syndrome of weakness of the sinus node, individual intolerance of the components of the drug, simultaneous application of threecentnersof the clinicalMr.tidspresses, pregnancy, lactation, at the same timeMr.th receptiontanole.

Carefully:Recently,Mr.Myoscardial myocardial infarction, chronic renal failure, antrhyoventicular block of the 1st degree.

Pregnancy and lactation:

RThe results of clinical studies of clonin in pregnant womenMr.are limited. Application
Clofelin during pregnancy is possible, when the benefit to the mother exceeds
risk for fetus / child (for emergencyfincreased blood pressure
dtions). Clonidine penetrates into breast milktoo, so when Mr.The need for
drug during lactation should be discontinued goreMr.th feeding.

Dosing and Administration:

Clopheline is administered intravenously. Doses should be selected strictly individually.
For yourt0.5-1.5 ml of clonidine solution in 10-20 ml of a 0.9% solution of sodium chloride and injected slowly - for 3-5 minutes. For intravenous drip, 4 ml of the solution is diluted in 500 ml of 5% racesta glucose thief and injected at an average rate of 20 cap / min. Maximum speed andMr.fusions - 120 cap / min. In severe cases, it is possible to administer clonidine solution parenterally 3-4 times a day (only in a hospital setting).

Side effects:FROMabout leatherMr.cover: rarely - itching, rash (including the edgePshepherd): redco-aloperation.
From the side of reproductionatsystem: often - erectal dysfunction; rarely - gynecomastia; frequency is unknown - decreased libido.
From the side of the support-motor apparatus: hourtabouttand neizvestna - muscle cramps lowerMr.their limbs, boland in the joints.
Othere: frequency unknown - thrombocytopenand I. weight gain, weakly positive reaction TOumbes. whetherxdaze, withdrawal syndrome.
From the side laboratory indicators: rarely - hyperglycemia: frequency unknown - change in functional liver samples.

Overdose:

Symptoms: aetiology, fromDissemination. Inhibition of respiration (inPlote to apnea), depression of consciousnessI (up to coma), changeMr.arterial pressureMr.(AD) - from a pronounced decrease to nesMr.Increasingly: weakness, vomiting, decrease or absence of reflexes, pallor of the skin, hypothermia, arrhythmia, miosis, weak reaction of pupils to light.
Treatment: symptomatic therapy (with bradycardiaandand - atropine, at higherMr.and AD - vasodilators, with a decrease - vasopreafromsors. With respiratory depression, coma and pronounced decrease in blood pressure - naloxone; regularth heart rate monitoring. BP (within 48 h), an electrocardiogram (ECG), blood glucose concentrations, thePBody structure. Hemodialysis is ineffective.

Interaction:

At oneMr.Modern applicationMr.withParats, depressing qethe nerve system, there may be a mutual enhancement of the deprimingeth influenceMr.on the central nervous system and the development of depressive disorders.
Hypotensionanda different effect of clonidandon weakened tricyclic antidepressants, anorexigenic (with the exception of fenfluramMr.a), sympathomimetandhenonsteroidal anti-inflammatory drugs and nifediPin: increase - vasodilators, diuretics, antihistamines. Beta-blockers and heartMr.glycosides increase the risk of developing bradycardiaandand or (in some cases) Plead to the development of atrioventricular blockade. When used simultaneously with
tenolol, aboutPruffling develops helldhypotensive effect, sedative effect, dry mouth. There are communitiesMr.reduction of the effectiveness of levodopa and Piribedil in patients with Parkinson's disease.

At simultaneous PRomeMr.with prazosin, a change in the antihypertensive
dethclonidine.

When used simultaneously with cyclosporine, there is a message of increased concentrationqiand cyclosporine in the blood plasma.
With simultaneous application of hormoneMr.oral contraceptives for oral administration may increase the sedative effect of clonidine.
ClofiliMr. strengthens miorelaksiruyuschee action tolperisone, anxylithiaction
tofizoPama, Prefromweedsth effect of phenylephrine.
Pri simultaneous application with myrtlePanother possible development of hypertensive crisis.

One-time use of clonidine with galloperidol strengthens the depression of the central nervous system.
At the same timeMr.th application with fromulpirid effect of clonidine is enhanced.
Clonidine weakens giPoglycemic actionart.hypoglycemic agents for
withintri and insulin.

Special instructions:

To prevent the occurrence of aboutrhetoricethe gandPfatherMr.intravenous injection
Clonidine must be in the position of leduring the introduction and during the 1,5-
2 hours after the administration.

During treatment,lOphelin prohibited the use of alcoholic beverages.

Effect on the ability to drive transp. cf. and fur:

ATThe loss of Clo-phenin on the ability to drive vehicles and mechanisms has not been studied due to the peculiarity of the drug dosage form (solution for
atnutrient administration).

Form release / dosage:

Solution for intravenousMr.aboutgabout the introduction of 0,1 mg / ml in ampoules but 1 ml.

Packaging:For 10 ampoules together with a vial for opening ampoules or a scarifier and instructions for PIn the cardboard box.

Storage conditions:List 1 forceTheactwtheir substances BCPC. In the defensesened from light and inaccessible to children.

Shelf life:

3 years. HDo not use after the expiration date.

Terms of leave from pharmacies:On prescription

Registration number:FS 42-2960-99

Date of registration:26.02.2008

The owner of the registration certificate:ORGANICS, JSC ORGANICS, JSC Russia

Manufacturer: & nbsp

ORGANICS, JSC Russia

Representation: & nbspDRUGSTORE FARMICON, LTD. DRUGSTORE FARMICON, LTD.

Information update date: & nbsp11.09.2014

Illustrated instructions

Instructions

Clofelin injection for 0.01% (Clophelin solution for injections 0,01%)