Clotrimazole
Antifungal agent from the group of imidazoles of a wide spectrum of action. It changes the permeability of cell membranes, which leads to the lysis of fungi. Effective against yeast fungi of the genus Candida and dermatophytes. Has antimicrobial effect against Gram-positive (Streptococcus, Staphylococcus) and Gram-negative bacteria (Gardnerella vaginalis, Bacteroides spp.), as well as in relation to Trichomonas vaginalis, Corynebacterium minutissimum, Malassezia furfur.
Metronidazole
The derivative of nitro-5-imidazole. It has antibacterial and antiprotozoal effect. It recovers 5-nitro group due to transport proteins of anaerobic bacteria and protozoan microorganisms. The restored 5-nitro group of metronidazole inhibits the synthesis of nucleic acids from the DNA of microorganism cells, which leads to their death.
Active with respect to Gardnerella vaginalis, Giardia lamblia, Entamoeba histolytica, as well as in relation to obligate anaerobes Bacteroides spp. (at including B. distasonis, B. ovatus, B. fragilis, B. vulgatus, B. thetaiotaomicron), Fusobacterium spp., Prevotella spp. (Prevotella bivia, Prevotella buccae, Prevotella disiens), Veillonella spp., some gram-positive microorganisms (Clostridium spp., Eubacterium spp., Peptococcus spp., Peptostreptococcus spp.).
With a mixed flora, it acts synergistically with antibiotics against aerobic bacteria. In combination with amoxicillin is active against Helicobacter pylori.