Combined drug for intravaginal application, the effectiveness of which is due to the presence in its composition of two components: metronidazole and clotrimazole.
Metronidazole is an antiprotozoal and antibacterial drug, a derivative of 5-nitroimidazole. The mechanism of action is the biochemical reduction of the 5-nitro group of metranidazole by intracellular transport proteins of anaerobic microorganisms and protozoa.The reduced 5-nitro group of metronidazole reacts with the DNA of a cell of microorganisms, inhibiting the synthesis of their nucleic acids, which leads to the death of bacteria.
Active with respect to Trichomonas vaginalis, Entamoeba histolytica, as well as Gram-negative anaerobes Bacteroides spp. (including W. Fragilis, AT. distasonis, AT. ovatus, AT. thetaiotaomicron, AT. vulgatus), Fusobacterium spp., and some Gram-positive anaerobes (sensory strains Eubacterium spp., Clostridium spp., Peptococcus niger, Peptostreptococcus spp.). The minimum inhibitory concentration for these strains is 0.125 - 6.25 μg / ml.
Clotrimazole - an antifungal agent from the group of imidazole derivatives for external and local (intravaginal) use, reduces the synthesis of ergosterol, which is an integral part of the cell membrane of the fungus, and leads to a change in its structure and properties.
In small concentrations, it acts fungistatically, and in large concentrations (more than 20 μg / ml) it is fungicidal, not only on proliferating cells. In fungicidal concentrations, it interacts with mitochondrial enzymes and peroxidases, resulting in an increase in the concentration of hydrogen peroxide to a toxic value, which also contributes to the destruction of fungal cells.
Active against pathogenic dermatophytes (Trichophyton rubrum, Trichophyton mentagrophytes, Epidermophyton floccosum, Microsporum canis), yeast and mold fungi (Candida spp., Torulopsis glabrata, kind Rhodotorula, Pityrosporum orbiculare).