With simultaneous application drugs lithiI and indapamide need careful monitoring of the concentration of lithium in blood plasma and correctiondosage, it is possible to increase the concentration of lithium in blood plasma with symptoms of an overdose, as well as with a salt-free diet (decrease in the release of lithium in the urine).
FROM astemizole, bepderin, erythromycin (with intravenous administration), halofantrine, pentamidine, sultopride, terfenadine and vincamine, antiarrhythmics IA class (quinidine, disopyramide, amiodarone, brethylium, sotalol) - the probability of occurrence of disturbances of a warm rhythm of type "pirouette" raises. Risk factors are hypokalemia, bradycardia, and previous lengthening of the interval QT.
FROM nonsteroidal anti-inflammatory drugs (with systemic administration), high doses of salicylates - there is a risk of acute renal failure in dehydrated patients (decreased glomerular filtration rate). It is necessary to compensate for the loss of fluid and, at the beginning of the treatment, monitor the function of the kidneys.
FROM amfothericin B (w / w), gluco- and mineralocorticosteroids (with a system assignment), tetrakozaktidom, laxatives, stimulating intestinal motility, cardiac glycosides - increases the risk of hypokalemia (additive effect).It is necessary to control the level of potassium in the blood plasma, ECG, if necessary - the appointment of appropriate treatment.
FROM baclofen - increased hypotensive effect.
FROM cyclosporin - an increase in the concentration of creatinine in the blood plasma, with an unchanged concentration of circulating cyclosporine.
FROM tricyclic antidepressants, antipsychotics - increases the hypotensive effect of indapamide and the risk of developing orthostatic hypotension increases (additive effect).
FROM antihypertensive drugs - increased risk of severe arterial hypotension.
FROM iodine-containing radiopaque agents (in high doses) - dehydration of the body and an increased risk of developing acute renal failure. Before using iodine-containing contrast agents, patients should compensate for fluid loss.
FROM calcium salts - an increase in the concentration of calcium ions in the blood plasma due to a decrease in their excretion in the urine.
FROM potassium-sparing diuretics (amiloride, spironolactone, triamterene) - risk of hypokalemia or hyperkalemia, especially in patients with diabetes mellitus and patients with impaired renal function.
FROM hypoglycemic drugs (insulin, sulfonamides) - ACE inhibitors can increase the hypoglycemic effect in patients with diabetes mellitus.
FROM anesthetics - strengthening of the hypotensive effect of angiotensin converting enzyme (ACE) inhibitors.
FROM allopurinol, cytostatics or immunosuppressants, corticosteroids administered systemically, or procainamide - risk of developing leukopenia.