Indapamide - instructions for use, dose, side effects, contraindications

Diuretic, a derivative of sulfonamide. Inhibits the reabsorption of sodium in the renal tubules, increases the excretion of sodium and chlorine, enhancing diuresis. Selectively blocks "slow" calcium channels, reduces the overall peripheral resistance of blood vessels, increases the elasticity of the walls of the arteries. Does not affect the metabolism of lipids (low-density lipoproteins, high-density lipoproteins, triglycerides) and carbohydrates.

Pharmacokinetics:

After oral administration, the empty stomach is completely absorbed in the gastrointestinal tract.The maximum concentration in the blood plasma is reached after 1 hour. The connection with plasma proteins is 79%. Therapeutic effect develops 1-2 hours after the start of the procedure.

Penetrates through the blood-brain and placental barrier, excreted in breast milk. Do not cumulate.

Metabolism in the liver.

The half-life is 18 hours. Elimination by the kidneys and with feces in the form of metabolites.

Indications:

It is used for the treatment of arterial hypertension.

ICD-10

IX.I10-I15.I15 Secondary Hypertension

IX.I10-I15.I10 Essential [primary] hypertension

Contraindications:

Hypokalemia, anuria, severe renal and hepatic insufficiency, acute disturbance of cerebral circulation, individual intolerance, children under 18 years of age.

Carefully:

Systemic diseases of connective tissue, stenocardia, renovascular hypertension, advanced age, hypersensitivity.

Pregnancy and lactation:

Recommendations for FDA - Category C. Contraindicated in pregnancy and lactation.

Dosing and Administration:

Inside for 1,25-2,5 mg once a day in the morning.

The highest daily dose: 5 mg.

The highest single dose: 2.5 mg.

Side effects:

Central and peripheral nervous system: headache, asthenia, nervousness, depression, irritability, anxiety, paresthesia.

Respiratory system: pharyngitis, sinusitis, cough, sometimes - rhinitis.

The cardiovascular system: arrhythmias, orthostatic hypotension, palpitation.

Digestive system: anorexia, dry mouth, gastralgia, vomiting, constipation, diarrhea, pancreatitis.

Dermatological reactions: hemorrhagic vasculitis.

Sense organs: visual disturbances, conjunctivitis.

urinary system: nocturia, polyuria.

Reproductive system: decreased potency and libido.

Allergic reactions.

Overdose:

Drowsiness, dizziness, confusion, respiratory depression. In patients with cirrhosis - the development of hepatic coma.

Treatment is symptomatic.

Interaction:

By reducing the excretion in the urine increases the concentration of lithium ions, which increases the risk of developing nephrotoxic action.

Cardiac glycosides, saluretics, mineralo- and glucocorticoids, amphotericin B (with intravenous administration), tetracosactide, laxatives increase the state of acidosis.

With simultaneous use with calcium preparations, hypercalcemia develops.

Reduces the hypotensive effect of glucocorticosteroids, non-steroidal anti-inflammatory drugs, sympathomimetics, tetracosactide.

Strengthens the hypotensive effect baclofen.

With the simultaneous use of iodine-containing contrast agents, dehydration develops.

Antipsychotic drugs and antidepressants strengthen the hypotensive effect, which can lead to orthostatic collapse.

Reduces the effect of indirect anticoagulants by increasing the concentration of clotting factors, due to increased production of liver and reducing the volume of circulating blood.

Strengthens the effect of nondepolarizing muscle relaxants.

Special instructions:

Monitoring of electrolyte blood composition

Indapamide can give a positive result in the conduct of doping control.

In the treatment it is not recommended to drive vehicles and work with moving mechanisms.

Instructions

Indapamide (Indapamidum)