Kodelanov (Kodelanov)

Composition Pharmacodynamics Indications Carefully Contraindications Dosing and Administration Side effects Form release / dosage
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Dosage form: & nbsppills
Composition:

Composition per one tablet:

Active substances: codeine 8 mg, terlanceolate grass mopsis - 20 mg, sodium bicarbonate - 200 mg, licorice roots - 200 mg.

Excipients: starch cartofel - 48,15 mg, pregelatinizing starch15,60 mg, carboxymethylcransmall sodium (sodium starch glycolate,Modzhela) - 5.20 mg, microcrystalline cellulose - 7.80 mg talc - 15.25 mg.

Description:Tablets from yellow to brown, with patches of a white to a dark brown color, Valium, with a facet and Valium.
Pharmacotherapeutic group:Antitussive combination drug
ATX: & nbsp
  • Opium derivatives in combination with expectorants
    • Pharmacodynamics:

    Combined drug, has a pronounced antitussive and expectorant effect. Codeine reduces the excitability of the cough center and interrupts reflexes exciting prolonged cough, has a weak analgesic and sedative effect. In small doses does not cause depression of the respiratory center, do not interfere with the function of the ciliated epithelium and does not reduce bronchial secretions. The herb of thermopsis contains isoquinoline alkaloids as active substances. Excites the respiratory and stimulates the vomiting centers.Has a pronounced expectorant effect, manifested in an increase in the secretory function of the bronchial glands, intensification of the activity of the ciliary epithelium and acceleration of the secretion of the secretion, an increase in the tone of the smooth muscles of the bronchi due to the central vagotropic effect.

    Pharmacokinetics:

    The biologically active substances contained in the plant possess ganglion-blocking properties. Sodium bicarbonate causes displacement of the pH of the bronchial mucus in the alkaline side, reduces the viscosity of phlegm. Stimulates the motor function of the ciliated epithelium and bronchioles. The licorice root exerts an expectorant, anti-inflammatory and antispasmodic effect. Expectorant properties are due to the content of glycyrrhizin, which stimulates the activity of ciliated epithelium in the trachea and bronchi, and also enhances the secretory function of the mucous membranes of the upper respiratory tract. Spasmolytic effect on smooth muscles is due to the content of flavone compounds (the most active is liquiditrolide). Anti-inflammatory effect is manifested in the relief of inflammatory reactions caused by histamine, serotonin and bradykinin.Glycyrrhizic acid, undergoing metabolic changes in the body, has a glucocorticosteroid-like effect.

    Indications:

    Unproductive cough (without sputum formation) and unproductive cough in adults and children over 12 years of age.

    Contraindications:

    Hypersensitivity, respiratory failure, asthmatic status, children's age (up to 12 years).

    Pregnancy and lactation:Use with caution in case of threatened miscarriage, pregnancy (especially I and III trimester), during breastfeeding (the risk of respiratory depression in a child due to the fact that codeine well penetrates through placental and blood-brain barrier).
    Dosing and Administration:

    Inside, 1 tablet 2-3 times a day. The maximum duration of treatment without a doctor's consultation is 5 days.

    Side effects:

    Allergic reactions: itching, hives; nausea, vomiting, constipation, headache, drowsiness. With prolonged uncontrolled use - the development of drug dependence to codeine.

    Overdose:

    Symptoms: vomiting, constipation, urinary retention, headache, drowsiness, impaired coordination of eyeball movements, miosis,depression of the respiratory center.

    Treatment: washing the stomach with activated carbon, potassium permanganate. Introduction of respiratory analeptics, atropine and a competitive physiological antagonist codeine - naloxone.

    Interaction:

    Pharmacodynamic: chloramphenicol inhibits the metabolism of codeine in the liver and thereby enhances its action in the body. With the simultaneous use of drugs, depressing the central nervous system (hypnotics, antipsychotic, etc.), it is possible to increase the sedative effect and depressant effect on the respiratory center. Codeine enhances the effect of ethanol on the psychomotor function.

    Pharmacokinetic: when using codeine in large doses, the action of cardiac glycosides can be intensified, because in connection with impaired peristalsis, absorption decreases. Adsorbents, astringents and enveloping agents, can reduce absorption in the gastrointestinal tract of alkaloids and codeine that make up the drug.

    Special instructions:

    In patients with impaired renal function the excretion of codeine is slowed, so reIt is recommended to extend the intervals between methods of the drug.

    When taking the drug, you can not useto drink alcohol.Athletes should followthread that the drug contains codeine andis doping.

    Effect on the ability to drive transp. cf. and fur:In connection with the possibility of the development of sedative action, during treatment is not recoMend to drive vehicles and engage in other potentially dangerous activities that require increased concentration of attention, speed of psychomotor and motor reactions.
    Form release / dosage:Pills.
    Packaging:For 10 tablets in a planar cell package. 1 contour pack with instructions for use in a pack of cardboard.
    Storage conditions:

    Store at a temperature not exceeding 25 ° C.

    Keep out of the reach of children.

    Shelf life:

    4 years. Do not use after the expiration date printed on the package.

    Terms of leave from pharmacies:On prescription
    Registration number:P N003177 / 01
    Date of registration:16.10.2008 / 12.05.2016
    Expiration Date:Unlimited
    The owner of the registration certificate:PHARMSTANDART-FORESTRY, OJSC PHARMSTANDART-FORESTRY, OJSC Russia
    Manufacturer: & nbsp
    Information update date: & nbsp30.01.2018
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