Classification of the incidence of adverse events (WHO): very often - not less than 10%; often - not less than 1%, but less than 10%; infrequently - not less than 0,1%, but less than 1%; rarely - not less than 0.01%, but less than 0.1%; very rarely - less than 0.01%, including individual reports.
The frequency of some unwanted effects, such as dizziness, arterial hypotension, bradycardia and visual disturbances, is proportional to the size of the dose. These effects usually develop with increasing dose and bowl - in patients with CHF and are usually unstable in nature. The most frequent of undesirable effects of carvedilol is dizziness, with ortostatic hypotension or without it, which develops at about 6% patients.
With the development of serious adverse effects, drug treatment should be discontinued.
On the part of the hematopoiesis and lymphatic system
- rarely: thrombocytopenia;
- very rarely: leukopenia.
From the nervous system
- often: dizziness, headache (especially at the beginning of treatment or when changing doses), general weakness;
- rarely: sleep disturbances, mood changes / thinking, paresthesia, myasthenia gravis, loss of consciousness.
From the sense organs
- often: decrease in secretion of tears (pay attention when using contact lenses);
- very rarely: visual disturbances, eye irritation.
From the side of the cardiovascular system
- very often: orthostatic hypotension;
- often: aetiology;
- rarely: worsening of the clinical picture of heart failure (especially with increasing doses), coldness of hands and feet, lowering blood pressure, fainting;
- Very rarely: disturbances of cardiac conduction, palpitation, aggravation of angina pectoris, occlusive disorders of peripheral circulation, "intermittent" lameness, peripheral edema.
From the respiratory system
- rarely: shortness of breath, bronchospasm (in predisposed patients), nasal congestion.
From the digestive system
- often: nausea, abdominal pain (up to 2%), mild diarrhea, dryness of the oral mucosa;
- rarely: decreased appetite, vomiting, flatulence, constipation;
- very rarely: dry mouth, increased activity of "liver" transaminases (alanine aminotransferase (ALT), aspartate aminotransferase (ACT), gamma-glutamyltransferase).
From the skin
- very rarely: exacerbation of psoriasis, alopecia, exfoliative dermatitis.
From the side of the musculoskeletal system
- rarely: pain in the muscles, bones, spine.
From the urinary system
- rarely: urination disorders;
- very rarely: severe renal dysfunction, edema.
Laboratory indicators
- rare: increased concentration of triglycerides and cholesterol;
From the side of metabolism
- often: weight gain, hypercholesterolemia; in patients with already existing diabetes - hyperglycemia or hypoglycemia.
Other
- often: general weakness;
- infrequently: reactions of increased sensitivity (skin itching, rash, urticaria), decreased potency;
- rarely: peripheral edema;
- very rarely: flushes of blood to the skin of the face, sneezing, flu-like syndrome.