Corvalol (Corvalol)

Composition Pharmacodynamics Indications Carefully Contraindications Dosing and Administration Side effects Form release / dosage
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Dosage form: & nbspdrops for oral administration
Composition:

Active substances:

ethyl bromoisovalericanate (ethyl ester of α-bromoisovaleric acid)

- 20.0 g

phenobarbital

-18.26 g

mint pepper oil

-1.42 g

Excipients:

sodium hydroxide (sodium hydroxide)

- 3.15 g

ethanol (ethyl alcohol) 95%

-580 ml

purified water.

-420 ml
Description:

Transparent, colorless liquid with a specific aromatic odor.

Pharmacotherapeutic group:Sedative remedy
ATX: & nbsp
  • Other sleeping pills and sedatives
    • Pharmacodynamics:

    Combined drug, the effect of which is due to the properties of its constituent substances. Has a sedative and spasmolytic effect. Facilitates the onset of natural sleep.

    Ethyl ester of alpha-bromoisovaleric acid has a sedative (like the effect of valerian) and spasmolytic action due to irritation of the predominantly receptors in the oral cavity and nasopharynx, a decrease in reflex excitability in the central parts of the nervous system and an increase in inhibition in neurons of the cortex and subcortical structures of the brain, as well as a decrease in activity of the central vasomotor centers and direct local antispasmodic effect on smooth muscles.

    Phenobarbital strengthens the sedative effect of other components, helps reduce excitation of the central nervous system and facilitates the onset of sleep.

    Peppermint oil has a reflex vasodilating, spasmolytic, mild choleretic, antiseptic effect. The mechanism of action is associated with the ability to irritate the "cold" receptors of the oral mucosa and reflexively expand primarily the vessels of the heart and brain. Eliminates the phenomena of flatulence due to irritation of the receptors of the mucous membrane of the gastrointestinal tract, strengthening the peristalsis of the intestine.

    Indications:

    Corvalol is prescribed as a symptomatic (soothing and vasodilating) remedy for functional disorders of the cardiovascular system, neurosis-like conditions, accompanied by increased irritability, with disturbed sleep, tachycardia, a state of excitation with pronounced vegetative manifestations; as an antispasmodic - for intestinal spasms.

    Contraindications:

    Hypersensitivity to the components of the drug; expressed violations of kidney and / or liver function, lactation period (if it is necessary to use during breastfeeding should decide whether to stop breastfeeding), pregnancy, alcoholism,craniocerebral trauma or brain disease, children under 3 years old.

    Carefully:

    Child age from 3 years.

    Dosing and Administration:

    The dose is set individually. Inside, before taking the food, pre-dissolved in a small amount (30-50 ml) of water.

    Single dose in adults is 30 drops, if necessary (for example, with tachycardia), a single dose can be maximally increased to 40-50 drops. Multiplicity of admission in adults - 2-3 times a day.

    Children from 3 years old Apply 1 drop per year for a child at a time per day. The need for a repeated dose is determined by the doctor depending on the clinical picture of the disease.

    Duration of the drug is determined by the doctor individually.

    Side effects:

    Drowsiness, dizziness, slow heart rate, decreased ability to concentrate, allergic reactions.

    With long-term admission - the phenomenon of bromism, addiction, drug dependence, withdrawal syndrome.

    Overdose:

    Symptoms: depression of the central nervous system, nystagmus, ataxia, lowering of arterial pressure, excitation, chronic intoxication with bromine (depression, apathy, rhinitis, conjunctivitis, hemorrhagic diathesis, violation of coordination of movements).

    Treatment: symptomatic; at oppression of the central nervous system - caffeine, nikethamide.

    Interaction:

    Drugs that depress the central nervous system, enhance the effect.

    Phenobarbital (inductor of microsomal oxidation) can reduce the effectiveness of drugs metabolized in the liver (including coumarin derivatives, griseofulvin, glucocorticosteroids, oral contraceptives); strengthens the action of local anesthetic, analgesic and hypnotics.

    Effect on the ability to drive transp. cf. and fur:

    The preparation contains 58% by volume of ethanol and phenobarbital, so patients taking Corvalol should refrain from driving and other potentially dangerous activities that require increased concentration and speed of psychomotor reactions.

    Form release / dosage:

    Drops for oral administration.

    Packaging:

    For 15 ml or 25 ml in bottles of droppers of orange glass, ukuporennyh stoppers, droppers with lids.

    Each vial-dropper along with the instruction for use is placed in a pack of cardboard.

    Storage conditions:

    In the dark place at a temperature of no higher than 15 ° C.

    Keep out of the reach of children.

    Shelf life:

    1 year 6 months.

    Do not use after expiry date.

    Terms of leave from pharmacies:Without recipe
    Registration number:P N000444 / 01
    Date of registration:21.10.2010 / 28.03.2017
    Expiration Date:Unlimited
    The owner of the registration certificate:MUROMSKY INSTRUMENT-MAKING PLANT, OJSC MUROMSKY INSTRUMENT-MAKING PLANT, OJSC Russia
    Manufacturer: & nbsp
    Representation: & nbspMUROMSKY INSTRUMENT-MAKING PLANT, OJSCMUROMSKY INSTRUMENT-MAKING PLANT, OJSC
    Information update date: & nbsp18.01.2018
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