Nikethamide - instructions for use, doses, side effects, contraindications

Due to the reflex stimulating effect on the chemoreceptors of the carotid glomeruli, the respiratory and vasomotor centers indirectly excite. It improves cardiac activity, raises arterial pressure and tone of vessels of the abdominal cavity.

With a reduced tone of the respiratory and vasomotor center has a central stimulating effect at the level of the medulla oblongata.

Pharmacokinetics:

With any method of administration, it is quickly and well absorbed. The duration of action is 15-60 minutes. Metabolism in the liver.

Elimination by the kidneys.

Indications:

Shock, collapse, asphyxia (including newborns), decreased vascular tone, respiratory depression, acute and chronic circulatory disorders, poisoning with barbiturates and narcotic drugs.

ICD-10

XX.Y10-Y34.Y11 Poisoning and exposure to anticonvulsants, sedatives, hypnotics, antiparkinsonian and psychotropic drugs, not classified elsewhere, with undetermined intentions

V.F50-F59.F53.9 Postpartum psychiatric disorder, unspecified

V.F10-F19.F18.9 Mental and behavioral disorders caused by the use of volatile solvents - mental disorder and behavioral disorder, unspecified

V.F10-F19.F11.9 Mental and behavioral disorders caused by the use of opioids - mental disorder and behavioral disorder, unspecified

XVI.P20-P29.P21 Asphyxia in childbirth

XVIII.R50-R69.R55 Fainting [syncope] and collapse

V.F10-F19.F13.9 Mental and behavioral disorders caused by the use of sedatives and hypnotics - mental disorder and behavioral disorder, unspecified

V.F10-F19.F12.9 Mental and behavioral disorders caused by cannabinoid use - mental disorder and behavioral disorder, unspecified

XX.Y10-Y34.Y12 Poisoning and exposure to drugs and psychodysleptics [hallucinogens], not classified elsewhere, with undetermined intentions

XIX.T36-T50.T43 Poisoning with psychotropic drugs, not elsewhere classified

Contraindications:

Convulsive readiness, epilepsy, hyperthermia in children, individual intolerance.

Carefully:

Brain edema, porphyria, airway obstruction, pheochromocytoma, hyperthyroidism, ischemic heart disease, severe arterial hypertension.

Pregnancy and lactation:

Recommendations for FDA - Category C. According to vital signs, it is used in pregnant women and during lactation.

Dosing and Administration:

For 1-2 ml of 25% solution intravenously, intramuscularly, subcutaneously 1-3 times / day. Children: 0.1-0.75 ml 25% solution.

In case of drug poisoning: slowly inject 5 ml of 25% solution.

The highest daily dose: 6 ml.

The highest single dose: 2 ml.

Side effects:

Central and peripheral nervous system: tonic-clonic convulsions, anxiety.

Respiratory system: cough, dyspnea, bronchospasm, "ricochet" hypoventilation, hiccough.

The cardiovascular system: arrhythmia.

Dermatological reactions: itching, infiltration and soreness at the injection site.

Allergic reactions.

Overdose:

Tonic-clonic convulsions.

Treatment is symptomatic.

Interaction:

Reduces the effects of narcotic analgesics, antipsychotic drugs, anxiolytics, hypnotics and anticonvulsants.

With the simultaneous use of PASC, anesthesia and phenothiazine derivatives reduce the effects of niketamide.

Enhances the effects of psychostimulants and antidepressants.

At simultaneous application with reserpine the convulsive effect amplifies.

Special instructions:

Given the soreness of subcutaneous and intramuscular injections, it is recommended to pre-inject 1 ml of a 0.5% solution of novocaine under the skin at the injection site.

Instructions

Nitcheamide (Nikethamidum)