Corvalol (Corvalol)

Composition Pharmacodynamics Indications Carefully Contraindications Dosing and Administration Side effects Form release / dosage
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Dosage form: & nbsppills
Composition:

1 tablet contains:

Active substances:

ethyl bromoisovalerianate (ethyl ester of alpha-bromoisovaleric acid) - 8.2 mg

phenobarbital - 7.5 mg

peppermint oil -0,58 mg.

Excipients: beta-cyclodextrin in terms of dry matter - 55.55 mg, potato starch - 13.00, mg, lactose monohydrate - 43.77 mg, microcrystalline cellulose - 10.50 mg, magnesium stearate - 0.90 mg.

Description:Round, flat, beveled to the edge of the tablet white or almost white with interspersed.
Pharmacotherapeutic group:Sedative remedy
ATX: & nbsp
  • Other sleeping pills and sedatives
    • Pharmacodynamics:

    Combined drug, the effect of which is due to the properties of its constituent substances. Has a sedative and spasmolytic effect. Facilitates the onset of natural sleep.

    Ethyl bromizovalerianate (ethyl ester of alpha-bromizovaleric acid) has a sedative (similar to the valerian effect) and spasmolytic effect due to irritation of predominantly oral and nasopharyngeal receptors, a decrease in reflex excitability in the central parts of the nervous system, and increased inhibition in neurons of the cortex and subcortical structures of the brain, and also a decrease in the activity of the central vasomotor centers and a direct local antispasmodic effect on smooth muscle.

    Phenobarbital enhances the sedative effect of other components, helps to reduce excitation of the central nervous system (CNS) and facilitates the onset of sleep.

    Peppermint oil has a reflex vasodilating, spasmolytic, mild choleretic, antiseptic effect. The mechanism of action is associated with the ability to irritate the "cold" receptors of the oral mucosa and reflexively expand primarily the vessels of the heart and brain. Eliminates the phenomena of flatulence due to irritation of the receptors of the mucous membrane of the gastrointestinal tract (GIT), strengthening the peristalsis of the intestine.

    Indications:Corvalol is prescribed as a symptomatic (soothing and vasodilating) remedy for functional disorders of the cardiovascular system, neurosis-like conditions, accompanied by increased irritability, with disturbed sleep, tachycardia, a state of excitation with pronounced vegetative manifestations; as an antispasmodic - for intestinal spasms.
    Contraindications:Hypersensitivity to the components of the drug; pronounced impairment of renal and / or liver function,lactation period (if breastfeeding is necessary, breastfeeding should be addressed), pregnancy, age 18 years (efficacy and safety not established), lactase deficiency, lactose intolerance, glucose-galactose malabsorption (the drug contains lactose).
    Dosing and Administration:

    The dose is set individually. Take in before eating, drink with water.

    Adults, as a rule, appoint 1-2 tablets 2 times a day.

    With tachycardia, a single dose can be increased to 3 tablets. The maximum daily dose is 6 tablets.

    Duration of the drug is determined by the doctor individually.

    Side effects:

    Drowsiness, dizziness, slow heart rate, decreased ability to concentrate, allergic reactions. There may be violations from the gastrointestinal tract. These phenomena occur with a decrease in the dose of the drug or discontinuation of the drug.

    With prolonged use of the drug, there may be a drug dependence, addiction, "withdrawal" syndrome, as well as the accumulation of bromine in the body and the development of bromism phenomena.

    Overdose:

    Symptoms: depression of the central nervous system, nystagmus, ataxia, lowering of blood pressure, excitation, dizziness, weakness, chronic intoxication with bromine (depression, apathy, rhinitis, conjunctivitis, hemorrhagic diathesis, impaired coordination of movements).

    Treatment: discontinuation of the drug, gastric lavage and symptomatic therapy, with CNS depression - caffeine, nikethamide.

    Interaction:

    Drugs that depress the central nervous system, enhance the effect of the drug. Phenobarbital (inductor of microsomal oxidation) can reduce the effectiveness of drugs metabolized in the liver (including coumarin derivatives, griseofulvin, glucocorticosteroids, oral contraceptives); strengthens the action of local anesthetic, analgesic and hypnotics. The drug increases the toxicity of methotrexate.

    The effect of the drug increases with the use of drugs valproic acid.

    Special instructions:The experience of using the drug in children under 18 years is absent. During the use of the drug should not drink alcohol.
    Effect on the ability to drive transp. cf. and fur:
    It is recommended to refrain from engaging in potentially dangerous activities that require a high concentration of attention and speed of psychomotor reactions (including vehicle management and work with complex mechanisms).
    Form release / dosage:Pills.
    Packaging:10 tablets in a planar cell package; for 2, 5 or 10 contour mesh packages in a pack of cardboard along with instructions for use.
    Storage conditions:In the dark place at a temperature of 15 ° C to 25 ° C. Keep out of the reach of children.
    Shelf life:

    2 years.

    Do not use after the expiry date printed on the package.

    Terms of leave from pharmacies:Without recipe
    Registration number:LS-002002
    Date of registration:30.08.2011 / 13.04.2017
    Expiration Date:Unlimited
    The owner of the registration certificate:PHARMA START, LTD. PHARMA START, LTD. Ukraine
    Manufacturer: & nbsp
    Representation: & nbspBopharm OJSCBopharm OJSCRussia
    Information update date: & nbsp18.01.2018
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