Included in the formulation
АТХ:C.01.E.B Other drugs for the treatment of heart disease
Pharmacodynamics:Phytopreparation in the form of lily of the valley herb tincture in the concentration of 100 g / l and herb of the motherwort 100 g / l. It has a blocking effect on the transport sodium / potassium ATP phase, after which the content of sodium ions in cardiomyocytes increases, calcium channels open, calcium enters the cells. An increase in the concentration of sodium accelerates the release of calcium from the sarcoplasmic reticulum and increases its content in the cell, thereby inhibiting the troponin complex, which inhibits the interaction of actin and myosin. The strength and speed of contraction of the cardiac muscle increases regardless of the preliminary stretching of the myocardium - the systole is shortened, becoming energetically economical. Increased myocardial contractility contributes to an increase in the shock volume of the blood.
Reduction of the end systolic and diastolic volumes of the heart together with an increase in myocardial tone reduces the size of the heart, reducing the need for myocardium in oxygen.
Carries out a negative chronotropic action, reduces the increased sympathetic activity, increasing the sensitivity of cardiopulmonary baroreceptors. Strengthening the activity of the vagus nerve, has an antiarrhythmic effect due to the elongation of the refractory period and a decrease in the rate of impulses through the atrioventricular node. The effect is improved by direct action on atrioventricular node and sympatholytic effects.
Pharmacokinetics:Binding to blood proteins up to 2-3%. It is not subjected to biotransformation, it is excreted by the kidneys unchanged.
Indications:It is used in complex therapy for sleep disorders, increased nervous excitability, mild heart failure, in the initial stage of arterial hypertension.
V.F50-F59.F51.0 Insomnia inorganic etiology
IX.I30-I52.I50.9 Heart failure, unspecified
IX.I10-I15.I15 Secondary Hypertension
IX.I10-I15.I10 Essential [primary] hypertension
Contraindications:Cardiosclerosis, myocarditis, endocarditis, widespread atherosclerosis.
Individual intolerance.
Carefully:Atrioventricular block I degree, hypertrophic subaortal stenosis, mitral stenosis, acute myocardial infarction, arteriovenous shunt, amyloidosis of the heart, pericardial tamponade, myocarditis.
Pregnancy and lactation:Recommendations for FDA - Category C. Penetrates through the placenta and enters the breast milk. During pregnancy and lactation, the use is contraindicated.
Dosing and Administration:Use in children
For 1-12 drops, depending on the number of years, 2-3 times a day.
Adults
Inside for 15-20 drops 2-3 times a day.
The highest daily dose: 60 drops, children - from 2 to 24 drops.
The highest single dose: 20 drops, children - from 1 to 12 drops.
Side effects:Nausea, vomiting, arrhythmia.
Allergic reactions.
Overdose:Increased side effects.
Treatment - lowering the dose of the drug.
Interaction:Catecholamines, diuretics, calcium preparations - contribute to the risk of glycoside intoxication.
Spironolactone, verapamil, nifedipine, quinidine - Increase the concentration of glycosides in blood plasma.
Reception antacids reduces absorption of the drug.
Inotropic effect increases with simultaneous application with riboflavin, thiamine chloride, pyridoxine, folic acid, methionine, inosine, phosphaden, anabolic steroids.
Special instructions:The likelihood of developing intoxication is increased in patients with impaired electrolyte metabolism (hypokalemia, hypernatremia, hypercalcemia), with obesity and in elderly patients.