Life® 900 (Life® 900)

Composition Pharmacodynamics Indications Carefully Contraindications Dosing and Administration Side effects Form release / dosage
Read on
Active substanceDeerslayer perforated grass extractDeerslayer perforated grass extract
Similar drugsTo uncover
  • Herbion® Hypericum
    pills inwards 
    KRKA, dd, Novo mesto, AO    
  • Deerskin extract dry
    raw materials.extract
    PEZ VILAR, SUE     Russia
  • Deerskin extract dry
    raw materials.extract
       
  • Life® 600
    pills inwards 
    Steigerwald Arzneimittelwerk GmbH     Germany
  • Life® 900
    pills inwards 
    Steigerwald Arzneimittelwerk GmbH     Germany
  • Negrustin®
    capsules inwards 
    Sandoz d.     Slovenia
    • Dosage form: & nbsptfilm-covered laths
    Composition:

    1 tablet contains:

    active ingredient:

    St. John's wort treacle extract in the ratio of medicinal raw materials - extract: 3-6: 1, extractant ethanol 80% (ml / ml) - 900.00 mg.

    Excipients:

    core tablet:

    silicon dioxide - 20.00 mg, talc - 30.13 mg, titanium dioxide (E 171) - 28.49 mg, sodium hydrogen carbonate - 96.00 mg, sodium carboxymethyl starch - 12.00 mg, croscarmellose sodium-12.15 mg , magnesium stearate-10.15 mg;

    tablet shell:

    Eudragit E 100 (butyl methacrylate, dimethylaminoethyl methacrylate and methyl methacrylate copolymer [1: 2: 1]) - 17.01 mg, macrogol 4 000 - 2.25 mg, riboflavin (E 101) - 5.57 mg.

    Pharmacotherapeutic group:An antidepressant of vegetable origin
    ATX: & nbsp

    A.13   Tetanus preparations

    N.07.X.X   Other drugs for the treatment of diseases of the nervous system

    Pharmacodynamics:

    The drug has antidepressant, anxiolytic and sedative effect. The therapeutic effect of St. John's wort is mainly associated with the presence in it of naphthodianthrenes hypericin and pseudo-hypericin, a derivative of floroglucin hyperphorin and flavonoids. Thanks to them, the drug positively affects the functional state of the central and autonomic nervous system, which improves mood and attention, increases mental and physical activity, normalizes sleep in patients with depression.

    The leading mechanism that causes the antidepressant effect of St. John's wort is oppression of the reuptake of norepinephrine, serotonin and dopamine.
    Pharmacokinetics:

    Hypericin and pseudo-hypericin:

    After a single oral intake of 1 tablet LIFE 900, the maximum concentration of hypericin in the blood plasma (3.8 ± 1.4 ng / ml) is detected after 7.9 ± 1.3 h. After 2.7 ± 0.7 h, the maximum concentration pseudohypericin (10.2 ± 3.9 ng / ml). The half-life is 18.7 ± 4.8 h for hypericin and 17.2 ± 8.4 h for pseudohypericin.

    Hypericins, due to their lipophilic nature, penetrate the blood-brain barrier.

    Hyperforin:

    After a single oral intake of 1 tablet Layf® 900, the maximum concentration in blood plasma (122 ± 45.5 ng / ml) is observed after 4.5 ± 1.2 hours. The half-life period is 17.5 ± 4.5 hours.

    With the daily application of Life 900 (1 tablet per day), the equilibrium concentration of hypericin, pseudo-hypericin and hyperforin in the blood plasma is reached within 14 days.

    Hypericin, pseudo-hypericin and hyperphorinum do not accumulate in the body.

    Indications:

    Major depressive episodes of mild to moderate severity.

    Contraindications:

    Allergies to St. John's wort or to any of the auxiliary substances of the drug, hypersensitivity of the skin to light (including in the anamnesis), depressive episodes of severe degree.

    Simultaneous use of cyclosporine, sirolimus, tacrolimus or indinavir and other protease inhibitors used to treat HIV, irinotecan and other cytotoxic agents, as well as antidepressants.

    It is not recommended to use in patients under the age of 18 years.

    Pregnancy and lactation:

    Use during pregnancy and during breastfeeding is not recommended.

    Dosing and Administration:

    Tablets are taken orally, without chewing, with a small amount of liquid, after breakfast.

    If not prescribed otherwise, it is recommended to use 1 tablet 1 time per day for 4-6 weeks.

    The decision to increase the daily dose or duration of treatment should be made only by the attending physician.

    Since the effect of the drug develops gradually, during the first 14 days it must be taken continuously.

    Side effects:

    The drug, as a rule, is well tolerated in recommended doses. Side effect develops rarely, not more than 1-3% of patients, and is represented mainly by the following undesirable phenomena:

    From the skin: photosensitization (more often in HIV-infected patients and patients with fair skin), allergic skin reactions (skin itching, skin rash, urticaria).

    From the central nervous system: anxiety, fatigue, headache.

    From the digestive system: nausea, abdominal pain (including in the epigastric region), flatulence, diarrhea, or constipation. In the literature it is reported that St. John's wort can cause dryness of the oral mucosa and anorexia, but so far they have not been observed with the use of the preparation Laif® 900.

    Overdose:

    Until now, there is no evidence of overdose of Lif® 900.

    In case of taking the drug in excessive doses, it is necessary to protect the skin from sunlight or UV irradiation for 2 weeks.

    Interaction:

    Pharmacokinetic interaction

    St John's wort preparations induce the activity of the enzymes of the cytochrome P 450 system. This may lead to a weakening and / or shortening of the duration of the clinical effect of the coumarinic anticoagulants (for example, fenprocumone, warfarin), immunosuppressants (eg, ciclosporin, sirolimus, tacrolimus), digoxin, indinavir and other protease inhibitors used to treat HIV, irinotecan and other cytotoxic agents, amitriptyline, midazolam, theophylline.

    In women with simultaneous application of St. John's wort with low-dose hormonal contraceptives, intermenstrual bleeding is possible.

    Pharmacodynamic interaction

    With simultaneous application of St. John's wort with a number of antidepressants (nefazodone, paroxetine, sertraline) the pharmacological effect of the latter can be strengthened. In some cases, unwanted (serotonergic) effects may increase, such as nausea, vomiting, a sense of fear, restlessness, confusion.

    It is theoretically possible to enhance the phototoxic effect of St. John's wort, when combined with photosensitizing preparations.

    The simultaneous application of St. John's wort with cyclosporine, sirolimus, tacrolimus or indinavir and other protease inhibitors used for HIV treatment, irinotecan and other cytostatics, as well as antidepressants is not recommended (see "Contraindications").

    In all cases where other medicines are prescribed, it is necessary to consult a doctor.

    Special instructions:

    During the period of taking the drug, patients should avoid intense UV radiation (prolonged exposure to the sun, under a UV lamp, in a solarium) or to perform the necessary sun protection measures.

    When used simultaneously with low-dose hormonal contraceptives for the period of treatment with the drug, the use of additional non-hormonal methods of contraception is recommended.

    Features of the drug at the first admission or when it is canceled

    Features of the drug during the first admission or when it was canceled was not noted.

    The actions of the doctor (paramedic), the patient in the admission of taking one or more doses of the drug

    If a person misses one or more doses, the patient should take the next dose prescribed by the doctor next time or indicated in the "Dosage regimen" section.

    Special precautions when destroying an unused preparation

    Special precautions for the destruction of unused medication are not provided.

    Effect on the ability to drive transp. cf. and fur:

    During the period of treatment, it is not recommended to operate vehicles and mechanisms.

    Form release / dosage:Tfilm coated abeyes, 900 mg.
    Packaging:20 pcs. 1, 3, 5 blisters are placed in a cardboard box together with instructions for use.
    Storage conditions:

    In a dry, the dark place at a temperature of no higher than 25 ° C.

    Keep out of the reach of children.

    Shelf life:

    2 years.

    Do not use after the expiration date printed on the package.

    Terms of leave from pharmacies:On prescription
    Registration number:LP-000424
    Date of registration:28.02.2011
    Expiration Date:28.02.2016
    The owner of the registration certificate:Steigerwald Arzneimittelwerk GmbHSteigerwald Arzneimittelwerk GmbH Germany
    Manufacturer: & nbsp
    Representation: & nbspRegard, OOORegard, OOORussia
    Information update date: & nbsp09.02.2018
    Illustrated instructions
      Instructions
      Up