As a rule, adverse reactions were mild or moderate and mainly related to suppression of the synthesis of estrogens.
The incidence of adverse reactions is estimated as follows: very often (≥ 10%), often (≥1%, <10%), infrequently (≥ 0.1%, <1%), rarely (≥ 0.01%, <0.1%), very rarely (<0, 01%), including individual messages.
From the side of the digestive system: often - nausea, vomiting, indigestion, constipation, diarrhea; infrequently - pain in the abdomen, stomatitis, dry mouth.
On the part of the liver and bile duct system: infrequently - increased activity of "hepatic" enzymes; very rarely - hepatitis.
From the nervous system: often - headache, dizziness, depression; infrequent anxiety, nervousness, irritability, drowsiness, insomnia, memory impairment, dysesthesia, paresthesia, hypoesthesia, eating disorders, episodes of cerebral circulation disorders, carpal tunnel syndrome.
On the part of the organs of hematopoiesis: infrequently, leukopenia.
From the side of the cardiovascular system: Rarely - palpitations, tachycardia, thrombophlebitis of superficial and deep veins, increased blood pressure (blood pressure), coronary heart disease (including for the first time detected or worsening of existing angina pectoris, angina requiring surgery, myocardial infarction, myocardial ischemia) thromboembolism; rarely - embolism of the pulmonary artery, thrombosis of the arteries, stroke.
From the respiratory system: infrequently - shortness of breath, cough.
From the skin and skin appendages: often - alopecia, excessive sweating, skin rash (including erythematous, maculopapular, vesicular rash, psoriasis-like rashes); infrequently - itchy skin, dry skin, urticaria; very rarely - angioedema, anaphylactic reactions,Lyell's syndrome (toxic epidermal necrolysis), Stevens-Johnson syndrome (malignant polymorphic exudative erythema).
From the musculoskeletal system: very often - arthralgia; often - myalgia, bone pain, osteoporosis, bone fractures; infrequently - arthritis; frequency is unknown - a snapping finger syndrome.
From the side of the organ of vision: infrequently - cataract, eye irritation, blurred vision.
From the side of the urinary system: infrequent - frequent urination, urinary tract infection.
From the side of the reproductive system: infrequently - vaginal bleeding, discharge from the vagina, dryness of the vagina, pain in the mammary glands.
Other: very often - paroxysmal sensations of heat ("hot flashes"); often - increased fatigue, asthenia, malaise, peripheral edema, weight gain, hypercholesterolemia, anorexia, increased appetite; infrequently - weight loss, thirst, hyperthermia (pyrexia), dry mucous membranes, generalized edema, pain in tumor foci.