The solution is administered intramuscularly or intravenously.
In connection with the fact that different schemes of application of Leucovorin-LENS® are used when choosing a specific dose, the physician should be guided by special medical literature.
Usually when the drug is administered in combination with high doses of methotrexate (12-15 g / m2) the administration begins 24 hours after the end of treatment with methotrexate at a dose of 10 mg / m2 every 6 hours for 72 hours or until the methotrexate concentration in the blood plasma is less than 5x10 -8 M.
In patients with acidic urine reaction, exudative effusions, impaired renal function, intestinal obstruction, a higher dose of Leucovorin-LENS® and / or longer duration of treatment may be required, since the excretion of methotrexate in this group of patients may be delayed. The use of leucovorin-LENS® in these cases is recommended to be based on the mandatory determination of the concentration of methotrexate in the blood plasma. To prevent the development of chronic renal failure, hydration (3 L / day) is performed and administered sodium hydrogen carbonate to maintain the pH of urine at 7 or higher.
At random overdose of methotrexate Leucovorin-LENS® is administered at a dose equal to or greater than the dose of methotrexate administered no later than 1 hour after the injection of methotrexate, then the drug is administered every 3 hours to 10 mg / m2 until the disappearance of signs of toxicity.
When combined with fluorouracil Leucovorin-LENS® is administered:
- in a dose of 200 mg / m2 intravenously slowly (at least 3 minutes) or intravenously drip followed by intravenous fluorouracil at a dose of 370 mg / m2 or
- in a dose of 20 mg / m2 intravenously followed by intravenous administration of fluorouracil at a dosage of 425 mg / m2
The drugs are administered daily for 5 days at intervals of 4-5 weeks between repeated courses.
In the treatment megaloblastic anemia caused by a deficiency of folic acid Leucovorin-LENS® is prescribed for 1 mg intramuscularly or intravenously per day.