Lomefloxacin + Prostate extract - instructions for use, dose, side effects, contraindications

Clinical and pharmacological group: & nbsp

Means that affect the metabolism of the prostate gland, and correctors urodynamics

Included in the formulation

Vitaprost® Plus

suppositories rect.

NIZHFARM, JSC Russia

АТХ:

G.04.B.X Other drugs for the treatment of urological diseases

Pharmacodynamics:

Combination drug with antibacterial and anti-inflammatory effect, used in diseases of the prostate gland.

Lomefloxacin is a broad spectrum antibacterial agent from the group of fluoroquinolones. Affects the bacterial enzyme DNA-gyrase, which provides supercoiling of DNA, forms a complex with its tetramer (subunit of gyrase A2B2) and disrupts transcription and replication of DNA, leading to the death of a microbial cell.

Highly active against gram-negative aerobic microorganisms: Neisseria gonorrhoeae, Neisseria meningitidis, Escherichia coli, Citrobacter diversus, Klebsiella pneumoniae, Enterobacter cloacae, Proteus vulgaris, Salmonella spp., Shigella spp., Moraxella morganii, Haemophilus influenzae, Haemophilus parainfluenzae, Pseudomonas aeruginosa, Legionella pneumophila.

Moderately sensitive to the drug Staphylococcus aureus, Staphylococcus epidermidis, Serratia liquefaciens, Serratia marcescens, Mycobacterium tuberculosis, Chlamydia trachomatis, Hafnia alvei, Citrobacter freundii, Aeromonas hydrophila, Proteus mirabilis, Proteus stuartii, Providencia rettgeri, Providencia alcalifaciens, Klebsiella oxytoca, Klebsiella ozaenae, Enterobacter aerogenes, Enterobacter agglomerans.

Resistant to the drug Streptococcus spp., Pseudomonas cepacia, Ureaplasma urealyticum, Treponema pallidum, Mycoplasma hominis and anaerobic bacteria.

On most microorganisms lomefloxacin acts at low concentrations (the concentration necessary to inhibit the growth of 90% of the strains, usually not more than 1 μg / ml). Resistance is rare.

Extract of the prostate has an organotropic effect on the prostate.Reduces the degree of edema, leukocyte infiltration of the prostate, normalizes the secretory function of epithelial cells, increases the number of lecithin grains in the secretion of the acini, stimulates the muscle tone of the bladder. Reduces thrombus formation, has antiaggregant activity, prevents the development of venous thrombosis in the prostate gland. Normalizes the parameters of the prostate and ejaculate. Reduces pain and discomfort, improves copulatory function.

Pharmacokinetics:

Lomefloxacin

Lamefloxacin intake in conjunction with other drugs from the combination does not affect the rate of its absorption from the gastrointestinal tract. Bioavailability of Lomefloxacin is more than 90%. The time to reach the maximum concentration is 1-1.5 hours. The half-life is 8-9 hours. Communication with blood proteins is negligible 10%. In small amounts, biotransformation is carried out in the liver with the formation of metabolites that have little antimicrobial activity. In 80% it is excreted by kidneys, feces, then and saliva. Hepatic failure does not affect the biotransformation of lomefloxacin. The average renal clearance is 145 ml / min.

Extract of prostate

Not studied.

Indications:Acute and chronic bacterial prostatitis, accompanied by inflammatory diseases of the genitourinary tract; states before and after surgery on the prostate gland.

ICD-10

XIV.N40-N51.N41 Inflammatory diseases of the prostate

Contraindications:

Hypersensitivity, children's age (under 18 years).

Carefully:

Cerebral atherosclerosis, epilepsy and other diseases of the central nervous system with epileptic syndrome.

Pregnancy and lactation:

Not applicable to women.

The category of FDA recommendations is not defined.

Dosing and Administration:

Rectal by 1 suppository once a day after enema or self-emptying of the intestine. The course of treatment continues until the disappearance of the pathogen in the secretion of the prostate and is from 10 to 30 days (individually for each patient).

Side effects:

With the exception of allergic reactions, the side effects of the drug are associated with the presence of lomefloxacin in its formulation.

Lomefloxacin

On the part of the digestive system: nausea, vomiting, dry mouth, gastralgia, abdominal pain, diarrhea, constipation, flatulence,pseudomembranous enterocolitis, dysphagia, discoloration of the tongue, decreased appetite, bulimia, taste distortion, dysbacteriosis, increased activity of hepatic transaminases, bleeding from the digestive tract.

From the central nervous system and peripheral nervous system: fatigue, malaise, asthenia, headache, dizziness, fainting, insomnia, hallucinations, convulsions, hyperkinesia, tremor, paresthesia, nervousness, anxiety, depression, arousal.

On the part of the genitourinary system: glomerulonephritis, dysuria, polyuria, anuria, albuminuria, bleeding from the urethra, crystalluria, hematuria, urinary retention, edema; in women - vaginitis, leukorrhea, intermenstrual bleeding, pain in the perineum, vaginal candidiasis; in men - orchitis, epididymitis.

From the side of metabolism: hypoglycemia, gout.

From the musculoskeletal system: arthralgia, spasms of the calf muscles, pain in the back and chest area.

On the part of the organs of hematopoiesis: thrombocytopenic purpura, increased fibrinolysis.

On the part of the respiratory system: dyspnoea, respiratory infections, bronchospasm, cough, hypersecretion of phlegm, flu-like syndrome, epistaxis.

From the senses: visual impairment, pain and noise in the ears, pain in the eyes.

From the cardiovascular system: lowering blood pressure, tachycardia, bradycardia, extrasystole, arrhythmias, progression of heart failure and angina, pulmonary embolism, myocardiopathy, phlebitis.

Allergic reactions: itching, hives, malignant exudative erythema (Stevens-Johnson syndrome).

Influence on the fetus: fetotoxic action (arthropathy).

Other: candidiasis, increased sweating, chills, thirst, reinfection, lymphadenopathy, photosensitivity.

Overdose:

Data on drug overdose are not provided.

Interaction:

With simultaneous use, the activity of oral anticoagulants increases and the toxicity of non-steroidal anti-inflammatory drugs increases.

Drugs that block tubular secretion, slow the withdrawal of the drug.

There is no cross-resistance with penicillins, cephalosporins, aminoglycosides, co-trimoxazole, metronidazole.

Special instructions:

At the time of drug treatment, simultaneous use of antimicrobial agents - fluoroquinolones - should be limited in order to avoid the development of an overdose and an increase in the frequency of side effectseffects.

With cirrhosis of the liver, there is no need for correction of the dosing regimen (with normal kidney function).

During the treatment period, prolonged exposure to sunlight and the use of artificial ultraviolet light should be avoided. At the first signs of photosensitivity (including increased sensitivity of the skin, burn, hyperemia, edema, blisters, rashes, itching, dermatitis), hypersensitivity, neurotoxicity (including agitation, convulsions, tremor, photophobia, confusion, toxic psychosis, hallucinations) therapy should be discontinued.

Impact on the ability to drive vehicles and manage mechanisms

During the treatment period, patients should be careful when driving vehicles and engaging in other potentially hazardous activities that require increased concentration and speed of psychomotor reactions.

Instructions

Lomefloxacin + Prostate extract (Lomefloxacinum + extractum Prostatae)