Active substanceLomefloxacin + Prostate extractLomefloxacin + Prostate extract
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  • Vitaprost® Plus
    suppositories rect. 
    NIZHFARM, JSC     Russia
  • Dosage form: & nbspfromrectal otic suppositories.
    Composition:

    One suppository contains:

    active ingredients: prostate extract - 100 mg (in terms of water-soluble peptides - 20 mg), lomefloxacin hydrochloride - 400 mg;

    Excipients: fat solid (Witepsol (grades H 15, W 5), Supposir (marks NA 15, NAS 50)) - until a suppository with a mass of 2.25 g.

    Description:

    Suppositories from white or almost white to light cream with a grayish hue of color, torpedo-shaped. The appearance of a white coating on the surface of the suppository is allowed.

    Pharmacotherapeutic group:Prostatitis is a chronic remedy
    ATX: & nbsp

    G.04.B.X   Other drugs for the treatment of urological diseases

    Pharmacodynamics:

    The combined Vitaprost® Plus preparation has antimicrobial and anti-inflammatory properties.

    Lomefloxacin - a broad spectrum antibacterial agent from the group of fluoroquinolones. Affects the bacterial enzyme DNA-gyrase, which provides supercoiling, forms a complex with its tetramer (subunit of A2B2 gyrase) and disrupts DNA transcription and replication, leading to the death of the microbial cell.

    Highly active for gram-negative aerobic microorganisms: Neisseria gonorrhoeae, Neisseria meningitides, Escherichia coli, Citrobacter diversus, Klebsiella pneumoniae, Enterobacter cloacae, Proteus vulgaris, Salmonella spp., Shigella spp., Moraxella morganii, Haemophilus influenzae e parainfluenzae, Legionella pneumophila, Pseudomonas aeruginosa.

    Moderately sensitive to the drug Staphylococcus aureus, Staphylococcus Epidermidis, Serratia liquefaciens, Serratia marcescens, Pseudomonas aeruginosa, Mycobacterium tuberculosis, Chlamydia trachomatis, Hafnia alvei, Citrobacter freundii, Aeromonas hydrophila, Proteus mirabilis, Proteus stuartii, Providencia rettgeri, Providencia alcalifaciens, Klebsiella oxytoca, Klebsiella ozaenae, Enterobacter aerogenes, Enterobacter agglomerans.

    Stable to the drug Streptococcus spp., Pseudomonas cepacia, Ureaplasma urealyticum, Treponema pallidum, Mycoplasma hominis and anaerobic bacteria.

    Most microorganisms act at low concentrations (the concentration necessary to control the growth of 90% of strains, usually not more than 1 μg / ml). Resistance is rare.

    Prostate extract has an organotropic effect on the prostate. Reduces the degree of edema, leukocyte infiltration of the prostate, normalizes the secretory function of epithelial cells, increases the number of lecithin grains in the secretion of the acini, stimulates the muscle tone of the bladder. Reduces thrombus formation, has antiaggregant activity, prevents the development of venous thrombosis in the prostate gland. Normalizes the parameters of the prostate and ejaculate. Reduces pain and discomfort, improves copulatory function.

    Indications:

    Acute and chronic bacterial prostatitis caused by sensitive microorganisms, including those accompanied by inflammatory diseases of the genito-urinary tract.

    Conditions before and after surgery on the prostate gland.

    Contraindications:

    Hypersensitivity to the components of the drug.

    Age to 18 years (period of formation and growth of the skeleton).

    Carefully:

    Cerebral atherosclerosis, epilepsy and other diseases of the central nervous system with epileptic syndrome.

    Dosing and Administration:

    Rectally, 1 suppository once a day after enema or self-emptying of the intestine.

    Before use, the suppository should be removed from the contour cell package.

    After the administration of Vitaprost® Plus, it is advisable to stay in bed for 30-40 minutes. The course of treatment continues until the disappearance of the pathogen in the secretion of the prostate and is from 10 to 30 days (the duration of treatment is determined by the doctor individually for each patient).

    Side effects:

    Side effects of the drug Vitaprost® Plus, with the exception of allergic reactions, are associated with the presence in its composition of an antibiotic lomefloxacin.

    Allergic reactions: itching, urticaria, photosensitivity, malignant exudative erythema (Stevens-Johnson syndrome).

    From the nervous system: asthenia, dizziness, nervousness, anxiety, fatigue, malaise, headache, fainting, insomnia, hallucinations, convulsions, hyperkinesia, tremor, paresthesia, depression, agitation.

    From the digestive system: pseudomembranous enterocolitis, dysbacteriosis, dryness of the oral mucosa, diarrhea or constipation, flatulence, discoloration of the tongue, decreased appetite or bulimia, a taste distortion, increased activity of "liver" transaminases.

    On the part of the organs of hematopoiesis and the system of hemostasis: bleeding from organs of the gastrointestinal tract, thrombocytopenia, increased fibrinolysis, lymphadenopathy, purpura, nasal bleeding.

    From the cardiovascular system: lowering blood pressure, tachycardia, bradycardia, extrasystole, arrhythmias, progression of heart failure and angina pectoris, pulmonary embolism, cardiomyopathy, phlebitis.

    From the genitourinary system: glomerulonephritis, dysuria, polyuria, anuria, albuminuria, urethral bleeding, crystalluria, hematuria, urinary retention, swelling; orchitis, epididymitis.

    From the side of metabolism: hypoglycemia, gout.

    From the musculoskeletal system: arthralgia, vasculitis, calf muscle cramps, back and chest pain.

    From the respiratory system: shortness of breath, bronchospasm, cough, hypersecretion of sputum, flu-like symptoms.

    From the sense organs: impaired vision, pain and noise in the ears, pain in the eyes.

    Other: increased sweating, chills, thirst, superinfection.

    Interaction:

    Increases the activity of oral anticoagulants and increases the toxicity of non-steroidal anti-inflammatory drugs.

    Drugs that block tubular secretion, slow the withdrawal of the drug.

    There is no cross-resistance with penicillins, cephalosporins, aminoglycosides, co-trimoxazole, metronidazole.

    Special instructions:

    During the treatment with Vitaprost® Plus, simultaneous use of antimicrobial agents - fluoroquinolones - should be limited in order to avoid the development of an overdose and an increase in the frequency of side effects.

    With cirrhosis of the liver, there is no need for correction of the dosing regimen (with normal kidney function).

    During the treatment period, prolonged exposure to sunlight and the use of artificial ultraviolet light should be avoided. At the first sign of photosensitization (increased skin sensitivity, burn, hyperemia, edema, blisters, rash, itching, dermatitis), hypersensitivity, neurotoxicity (excitation, convulsions, tremors, photophobia, confusion, toxic psychosis, hallucinations) therapy should be discontinued.

    Effect on the ability to drive transp. cf. and fur:

    During the treatment period, care must be taken when driving vehicles and engaging in other potentially hazardous activities that require increased concentration and speed of psychomotor reactions.

    Form release / dosage:

    Suppositories rectal, 400 mg + 20 mg.

    Packaging:

    5 suppositories are placed in a contour mesh package made of a film of polyvinyl chloride laminated polyethylene.

    One or two contour mesh packages, along with instructions for the use of the drug, are placed in a pack of cardboard.

    Storage conditions:

    At a temperature of no higher than 25 ° C.

    Keep out of the reach of children.

    Shelf life:

    2 years.

    Do not use the drug after the expiration date.

    Terms of leave from pharmacies:Without recipe
    Registration number:LSR-002821/07
    Date of registration:20.09.2007 / 25.08.2016
    Expiration Date:Unlimited
    The owner of the registration certificate:NIZHFARM, JSC NIZHFARM, JSC Russia
    Manufacturer: & nbsp
    Information update date: & nbsp21.02.2017
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