Side effects are limited to those previously observed when using losartan and / or hydrochlorothiazide.
The most common side effects in the treatment of essential hypertension include dizziness.
Allergic reactions: anaphylactic reactions, angioedema, including laryngeal and / or tongue edema, resulting in airway obstruction, and / or swelling of the face, lips, pharynx and / or tongue occasionally noted with losartan. Some of these patients had angioedema earlier with other drugs, including ACE inhibitors. Very rarely, when taking losartan, there were manifestations of vasculitis, including Shenlen-Henoch disease.
From the cardiovascular system: marked decrease in blood pressure, less than 1% - bradycardia, arrhythmias, angina pectoris;
From the digestive system: when receiving losartan, rare (less than 1%) cases of hepatitis, diarrhea, decreased appetite, dry mouth, toothache, vomiting, flatulence, gastritis were reported.
From the respiratory system: dyspnea, bronchitis, rhinitis, with the use of losartan - cough.
From the skin: urticaria, less than 1% - dryness, skin hyperemia, photosensitivity, increased sweating, alopecia.
From the genitourinary system: less than 1% - mandatory urination, urinary tract infections, impaired renal function, weakening of libido, decreased potency.
From the musculoskeletal system: 1% or more - pain in the legs, less than 1% - pain in the shoulder, knee, arthritis, fibromyalgia.
From the nervous system and sensory organs: less than 1% - anxiety, sleep disorders, drowsiness, memory disorders, peripheral neuropathy, paresthesia, hypesthesia, tremor, ataxia, depression, loss of consciousness, ringing in the ears, taste disturbance, vision change, conjunctivitis.
Laboratory indicators: rarely (less than 1%) hyperkalemia (potassium serum more than 5.5 mmol / l), increased activity of "hepatic" enzymes.
Other: less than 1% - fever, gout.