Inside, intravenously. The dose, route of administration, duration of the course of treatment are determined individually depending on the indications, the patient's condition, clinical and mycological effect. The daily dose depends on the nature and severity of the infection. In children, the daily dose should not exceed the maximum daily dose for adults. When transferring a patient from intravenous administration of fluconazole to oral administration and vice versa, there is no need to change the daily dose.
Adults with cryptococcosis and generalized candidiasis - intravenously, by mouth, 400 mg on the first day, then 200-400 mg per day; with oropharyngeal candidiasis - inside, 50-100 mg per day for 7-14 days; with vaginal candidiasis - inside, 150 mg once, in chronic form - once a month for 150 mg for 4-12 months; with mycosis - 150 mg once a week. Duration of therapy is determined individually, it varies from 4 to 12 months. Some patients may need more frequent use.
To prevent the recurrence of oropharyngeal candidiasis in AIDS patients after completing the full course of primary therapy - 150 mg once a week.
With atrophic oral candidiasis associated with the wearing of dentures, 50 mg once a day for 14 days in combination with local antiseptic agents for prosthesis treatment.
With other localizations of candidiasis (with the exception of the genital), for example, with esophagitis, non-invasive bronchopulmonary disease, candiduria, candidiasis of the skin and mucous membranes, and so on, the effective dose is usually 150 mg per day with a treatment duration of 14-30 days.
With balanitis caused by Candida, fluconazole is administered orally once a day at a dose of 150 mg per day.
For the prevention of candidiasis, the recommended dose is 50-400 mg once a day, depending on the degree of risk of fungal infection. For the prevention of candidiasis in patients with malignant neoplasms the recommended dose of fluconazole is 150-400 mg once a day, depending on the degree of risk of fungal infection. If there is a high risk of generalized infection, for example, in patients with expected severe or persistent neutropenia, the recommended dose is 400 mg per day. Fluconazole appoint a few days before the expected appearance of neutropenia; after an increase in the number of neutrophils more than 1 thousand / μl, treatment is continued for another 7 days.
With mycosis of the skin, including mycosis of the feet, skin of the inguinal region, and skin candidiasis, the recommended dose is 150 mg once a week or 50 mg once a day, the dosage regimen depends on the clinical and mycological effect. Duration of therapy in usual cases is 2-4 weeks, however, with foot mycoses, longer therapy (up to 6 weeks) may be required.
With pityriasis - 300 mg (2 capsules of 150 mg) once a week for 2 weeks, some patients require a third dose of 300 mg per week, while in some cases it is sufficient to receive 300-400 mg once; an alternative treatment regimen is to administer 50 mg once a day for 2-4 weeks.
With onychomycosis, the recommended dose is 150 mg once a week. Treatment should continue until the replacement of the infected nail (growth of uninfected nail). For the repeated growth of nails on the fingers and toes, it normally takes 3-6 months and 6-12 months, respectively.
With deep endemic mycoses, it may be necessary to use the drug at a dose of 200 mg (4 capsules of 50 mg) - 400 mg (8 capsules 50 mg) per day for up to 2 years. The duration of therapy is determined individually; it can be 11-24 months with coccidioidomycosis, 2-17 months with paracoccidioidomycosis, 1-16 months with sporotrichosis and 3-17 months with histoplasmosis.
Children with generalized candidiasis - 6-12 mg / kg per day, with candidiasis of the mucous membranes - 3-6 mg / kg per day, for the prevention of fungal infections - 3-12 mg / kg per day.