Magnesium orotate (Magnesii orotas)

Pharmacodynamics Pharmacokinetics Indications Carefully Contraindications Dosing and Administration Side effects
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Clinical and pharmacological group: & nbsp

Macro and microelements

Metabolics

Included in the formulation
  • Magnemax
    pills inwards 
    OBOLENSKOE PHARMACEUTICAL ENTERPRISE, CJSC     Russia
  • Magnnerot®
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    Wörwag Pharma GmbH & Co. KG. KG     Germany
    • АТХ:

    A.12.C.C   Preparations of magnesium

    A.12.C.C.09   Magnesium orotate

    Pharmacodynamics:It replenishes the deficiency of magnesium and orotic acid, has spasmolytic, antiarrhythmic, antiaggregant effect, has anabolic, hepatoprotective and uricosuric properties.
    Magnesium is the most important macroelement necessary to ensure energy processes (transport, storage and utilization of energy). Participates in the exchange of proteins, fats, carbohydrates and nucleic acids, is a cofactor of many enzymatic reactions (hydrolysis and phosphate group transfer, functioning of Na + / K + -, Ca2 + -ATPase and proton pump). Controls the balance of intracellular potassium, takes part in the process of neuromuscular excitation, inhibits neuromuscular transmission. A natural physiological calcium antagonist. Participates in the regulation of myocardial contractility. Replenishing the deficiency of magnesium, contributes to increased resistance to stress. In acute myocardial infarction, magnesium somewhat reduces systemic vascular resistance, increases coronary blood flow, prevents coronary spasm, acts as a cardioprotector,eliminating the intracellular deficiency of not only magnesium, but also potassium, phosphates (simultaneously reducing the content of calcium and sodium), reduces the zone of heart attack and the severity of heart failure. Reduces the synthesis of thromboxane B2 and inhibits the aggregation of platelets, incl. thrombin-induced.
    Orotic acid - an endogenous metabolite, stimulates the synthesis of nucleic acids, enhances regenerative processes in tissues, has a general stimulating effect on metabolism, increases the formation of albumin in the liver (especially with prolonged hypoxia), promotes fixation of Mg2 + in the cell and the manifestation of its action.
    Pharmacokinetics:Magnesium absorption occurs mainly in the duodenum and in the upper parts of the small intestine, as well as in the lower parts of the ileum, in the large intestine, incl. - in the caecum. Approximately 35-40% of the dose is absorbed. Exogenously introduced magnesium is exchanged with endogenous depots. Hypomagnesemia stimulates the absorption of magnesium ions. The presence of orotic acid helps to improve the absorption of magnesium.
    Magnesium is mainly excreted by the kidneys with urine; only a small amount is released through sweat and milk.Excretion decreases with magnesium deficiency and increases with its excess. In the case of complete filling of the depot with magnesium, the renal elimination of the orally administered magnesium is equal to the degree of its absorption.
    Orotate mainly enters the synthesis of pyrimidine nucleotides or decomposes into aspartate and CO2. A small amount of it enters the milk and is excreted in the urine.
    Indications:In complex treatment and as a prophylaxis in the following diseases: myocardial infarction; angina pectoris; chronic heart failure; cardiac arrhythmias caused by magnesium deficiency; spastic conditions - pain and muscle spasms (including angiospasm); atherosclerosis; arteritis; violation of lipid metabolism, as well as with increased physical exertion.
    ICD-10

    IV.E50-E64.E61.2   Magnesium deficiency

    IV.E70-E90.E78.5   Hyperlipidemia, unspecified

    IV.E70-E90.E78.9   Disorders of lipoprotein metabolism, unspecified

    IX.I20-I25.I20   Angina pectoris [angina pectoris]

    IX.I20-I25.I21   Acute myocardial infarction

    IX.I30-I52.I49.9   Disorder of heart rhythm, unspecified

    IX.I30-I52.I50.0   Congestive heart failure

    IX.I70-I79.I70.9   Generalized and unspecified atherosclerosis

    IX.I70-I79.I73.8   Other specified diseases of peripheral vessels

    IX.I70-I79.I73.9   Peripheral vascular disease, unspecified

    IX.I70-I79.I77.6   Arteritis, unspecified

    XIII.M70-M79.M79.1   Myalgia

    XVIII.R25-R29.R25.2   Cramp and spasm

    XVIII.R25-R29.R29.0   Tetany

    XXI.Z55-Z65.Z56.6   Other physical and mental stress in work

    XXI.Z30-Z39.Z33   Pregnancy condition

    Contraindications:Hypersensitivity; impaired renal function; urolithiasis disease; predisposition to the formation of calcium-magnesium-ammonium-phosphate stones; cirrhosis of the liver with ascites; children and adolescence up to 18 years.
    Carefully:Renal failure.
    Pregnancy and lactation:The use of pregnancy and during lactation is possible strictly according to the indications, if the potential benefit to the mother exceeds the potential risk to the fetus and the child. In these periods, the need for magnesium is greatly increased. If its content is not balanced, it can lead to serious complications, incl. to miscarriage.
    Action category for the fetus by FDA-C
    Dosing and Administration:Inside, before eating, squeezed a small amount of liquid, 1 g 3 times / day for 7 days, then 0.5 g 2-3 times / day daily. Duration of treatment at least 4-6 weeks. The question of conducting repeated courses of treatment is decided individually. Can be used for a long time.
    At night cramps calf muscles recommend taking in the evening to 1-1.5 g.
    Side effects:From the digestive tract: unstable stools and diarrhea (when taken in high doses), which usually pass on their own with a lower dose.
    Other: allergic reactions are possible.
    Overdose:With normal kidney function, magnesium ingestion does not cause toxic reactions. Magnesium poisoning can develop with kidney failure. Toxic effects mainly depend on the concentration of magnesium in the blood serum. Symptoms: decreased blood pressure, nausea, vomiting, depression, slowing reflexes, respiratory depression, coma, cardiac arrest, anuric syndrome. Treatment: rehydration, forced diuresis. With renal failure, hemodialysis or peritoneal dialysis is necessary.
    Interaction:With the simultaneous administration of magnesium-containing drugs with preparations of iron, sodium fluoride and tetracyclines, absorption of the latter may decrease. Therefore, the drugs should be taken at intervals of 2-3 hours.
    Oral contraceptives, diuretics, muscle relaxants, GCS, insulin reduce the effect of magnesium orotate.
    Reduces the degree of magnesium deficiency and the risk of complications associated with it when taking diuretics, aminoglycosides, cisplatin, cyclosporine, amphotericin, pentamidine, methotrexate, laxatives.
    Special instructions:Can be used for a long time. It should be borne in mind that the magnesium deficiency in the body can lead to gastrointestinal diseases, the consumption of foods with a reduced content of magnesium, exercise (due to increased sweating); chronic alcoholism (due to a decrease in the resorption of magnesium in the renal tubules and increase the excretion of magnesium from the body), taking certain medications (cardiac glycosides, aminoglycoside antibiotics, oral contraceptives, diuretics, laxatives, glucocorticosteroids); conditions requiring increased intake of magnesium (hypodynamia, stress, pregnancy and lactation); prolonged exposure to the sun.
    Magnesium orotate does not affect the ability to drive vehicles and other activities that require a high concentration of attention and speed of psychomotor reactions.

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