Active substanceMagnesium citrateMagnesium citrate Similar drugsTo uncover Magnesium-Diasporal® 300 granules inwards Protina Pharmaceutisze GmbH Germany Dosage form: & nbspGranules for solution for oral administration. Composition:One packet (5.0 grams) contains: Active substance: Magnesium citrate 1830.0 mg (equivalent to a magnesium content of 295.7 mg)Excipients: sucrose 2341.2 mg, citric acid 600.0 mg. sodium hydrogen carbonate 145.0 mg, flavoring orange 22.3 mg. riboflavin (E101) 1.5 mg. Description:A mixture of irregularly shaped granules and a yellow powder. Pharmacotherapeutic group:Magnesium preparation ATX: & nbspA.12.C.C Preparations of magnesiumA.12.C.C.04 Magnesium citrate Pharmacodynamics:Magnesium participates in most metabolic reactions, activates more than 300 enzymes. An indispensable element in the processes ensuring the receipt and expenditure of energy. Participates in the balance of electrolytes, ion transport, membrane permeability, in the regulation of nerve impulse transmission and in muscle contraction. It is a natural calcium antagonist. Pharmacokinetics:Magnesium is slowly and not completely absorbed in the gastrointestinal tract, with the syndrome of malabsorption and eating foods rich in fats,the absorption of magnesium is reduced. The unabsorbed part of magnesium is released through the intestine.Serum contains about 1% of absorbed magnesium (0.8 - 1.0 mmol / l). Approximately 45% of magnesium binds to intracellular proteins and macroergic phosphates and is deposited in skeletal muscles, kidneys, liver and myocardium. The remainder is deposited in bone tissue; in small amounts - in the tissue fluid and red blood cells.Magnesium ions penetrate the blood-brain barrier and the placental barrier.Absorbed magnesium is eliminated by the kidneys, and only a small part is excreted with bile and through sweat glands. Partially resorbed in renal tubules. The rate of excretion by the kidneys is proportional to the concentration in the plasma and the value of glomerular filtration. Indications:Magnesium deficiency, accompanied by such symptoms as: minor sleep disorders, increased irritability, mild anxiety, fatigue, spasm of the calf muscles. Contraindications:Increased individual sensitivity to the components of the drug, severe renal failure, atrioventricular blockade, myasthenia gravis, hypermagnesia, children under 12 years.In connection with the presence of sucrose Magnesium - Diasporal 300 is contraindicated in case of intolerancefructose, a syndrome of impaired glucose absorption or galactose, or with a deficiency of sucrose-isomaltase. Carefully:Moderate renal failure (risk of hypermagnesemia). Pregnancy and lactation:Use of the drug during pregnancy only on the advice of a doctor.Taking into account that magnesium penetrates into the mother's milk, it is recommended to stop feeding if necessary. Dosing and Administration:Inside.Adults and children over 12 years of age - 1 package every day. Dissolve the contents of 1 packet in 1/2 cup of fruit juice, tea or water.The average duration of treatment is 1 month. Treatment should be discontinued after normalizing the magnesium level in the blood. Side effects:There may be allergic reactions, disorders of the gastrointestinal tract: diarrhea, abdominal pain, constipation, nausea, flatulence. Overdose:With normal kidney function, oral magnesium intake does not cause toxic reactions. Only on the background of severe renal failure can there be reported symptoms.Symptoms of overdose: decrease in arterial pressure, nausea, vomiting, slowing of reflexes, respiratory depression, coma, cardiac arrest, anuria.Treatment: Intravenous administration of calcium and intramuscular or subcutaneous injection of 1 - 2 ampoules (0.5-1 mg / ml) of neostigmine methyl sulfate; intravenous or oral administration of 0.9% sodium chloride; in the case of renal failure - hemodialysis or peritoneal dialysis. Interaction:Aminoglycoside antibiotics, cisplatin and ciclosporin accelerate the excretion of magnesium. Ions of magnesium, iron, fluorides, and tetracycline, mutually affect each other's abstinence, therefore it is necessary to observe a 2-3 hour interval between taking Magnesium Diasporal® 300 and preparations containing the above substances. Magnesium weakens the effect of indirect anticoagulants, reduces the absorption of iron. The simultaneous use of drugs containing phosphates or calcium salts can significantly reduce the absorption of magnesium in the gastrointestinal tract. Effect on the ability to drive transp. cf. and fur:The drug does not affect the ability to control machines and mechanisms. Form release / dosage:Granules for solution for oral administration. Packaging:By 5.0 grams per package of combined material (paper, aluminum foil, polyethylene film). 2 bags, heat sealed joint. For 2 bags, connected by a heat-sealable seam with the text of the instruction, individually or by 20 or 50 packets together with instructions for use in a cardboard box. Storage conditions:At a temperature of 15 to 25 ° C.Keep out of the reach of children! Shelf life:3 yearsDo not use after the expiry date printed on the package. Terms of leave from pharmacies:On prescription Registration number:LP-000104 Date of registration:23.12.2010 The owner of the registration certificate:Protina Pharmaceutisze GmbHProtina Pharmaceutisze GmbH Germany Manufacturer: & nbspPROTINA PHARMAZEUTISHE, GmbH Germany Representation: & nbspKOSMOFARM LLCKOSMOFARM LLC Information update date: & nbsp04.09.2014 Illustrated instructions × Illustrated instructions Instructions