Included in the formulation
АТХ:A.12.C.C Preparations of magnesium
A.12.C.C.04 Magnesium citrate
Pharmacodynamics:Pharmacological action - the replacement of magnesium deficiency, the normalization of metabolic processes.
Magnesium is a vital element, participates in most metabolic reactions, activates more than 300 enzymes, an indispensable element in processes that ensure the intake and consumption of energy. Participates in maintaining electrolyte balance, ion transport, membrane permeability, nerve impulse transmission and muscle contraction (reducing neuronal excitability and delaying neuromuscular transmission), are calcium antagonists.
Pharmacokinetics:Magnesium is slowly and not completely absorbed into the digestive tract, with malabsorption syndrome and the consumption of food rich in fats, the absorption of magnesium is reduced. The unabsorbed part of magnesium is released through the intestine.
Serum contains about 1% of absorbed magnesium (0.8-1 mmol / l). Approximately 45% of magnesium binds to intracellular proteins and macroergic phosphates and is deposited in skeletal muscles, kidneys, liver and myocardium. The remainder is deposited in bone tissue; in small amounts - in the tissue fluid and red blood cells.
Magnesium ions penetrate the GEB and the placental barrier.
Absorbed magnesium is eliminated by the kidneys, and only a small part is excreted with bile and through sweat glands. Partially reabsorbed in the renal tubules. The rate of excretion by the kidneys is proportional to the concentration in the plasma and the value of glomerular filtration.
Indications:Magnesium deficiency, accompanied by symptoms such as minor sleep disorders, increased irritability, mild anxiety, fatigue, and spasm of the calf muscles.
IV.E50-E64.E61.2 Magnesium deficiency
XVIII.R25-R29.R25.2 Cramp and spasm
XVIII.R50-R69.R53 Malaise and fatigue
Contraindications:Hypersensitivity, severe renal failure; atrioventricular block; myasthenia gravis; hypermagnesia; children's age (up to 12 years).
Carefully:Moderate renal failure (risk of hypermagnesemia).
Pregnancy and lactation:Use of the drug during pregnancy only on the advice of a doctor.
Taking into account that magnesium penetrates into the mother's milk, it is recommended to stop breastfeeding if necessary.
Action category for the fetus by FDA - not defined.
Adequate and well-controlled studies in humans and animals have not been conducted.
Dosing and Administration:Inside. Adults and children over 12 years of age - 300-450 mg (in terms of magnesium) daily. Dissolve the contents of 1 pack. in 1/2 cup of fruit juice, tea or water. Usually the duration of treatment is 1 month. Treatment should be discontinued after normalizing the magnesium level in the blood.
Side effects:Possible allergic reactions, disorders of the gastrointestinal tract: with prolonged use in large doses - diarrhea, abdominal pain, constipation, nausea, flatulence.
Overdose:With normal kidney function, oral magnesium intake does not cause toxic reactions. Only against a background of severe renal failure may the following symptoms occur: a decrease in blood pressure, nausea, vomiting, slowing of reflexes, respiratory depression, coma, cardiac arrest, anuria.
Treatment: iv administration of calcium and / or im injection 1-2 amp. (0.5-1 mg / ml) of neostigmine methyl sulfate; intravenous or oral administration of 0.9% sodium chloride; in the case of renal failure - hemodialysis or peritoneal dialysis.
Interaction:Aminoglycoside antibiotics, cisplatin and ciclosporin accelerate the excretion of magnesium.
Ions of magnesium, iron, fluorides and tetracycline mutually affect the absorption of each other, so it is necessary to observe a 2-3-hour interval between the intake of magnesium citrate and LS containing the above substances.
Magnesium weakens the effect of indirect anticoagulants, reduces the absorption of iron.
The simultaneous use of drugs containing phosphates or calcium salts can significantly reduce the absorption of magnesium in the digestive tract.
Special instructions:It should be borne in mind that with frequent use of laxatives, alcohol, large mental and physical loads, the need for magnesium increases.
Magnesium citrate does not affect the ability to control machines and mechanisms.