Marelin (MARELIN)

Composition Pharmacodynamics Indications Carefully Contraindications Dosing and Administration Side effects Form release / dosage
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Dosage form: & nbspcoated tablets
Composition:

For one tablet:

Active components:

Salicylamide

in terms of dry matter

35,000 mg

Mareni dye dry extract

with the content of anthraglycosides in terms of

rubrithrithric acid and absolutely dry matter 8.0%

32.500 mg

Goldenrod Canadian extract dry

with the content of the amount of flavonoids in terms of

rutin and absolutely dry matter 12.0%

25,000 mg

Horsetail field extract dry

with the content of the amount of flavonoids in terms of

rutin and absolutely dry substance 1.0%

15,000 mg

Kellin

in terms of dry matter

2,500 mg

Lily of the valley glycoside

with the content of the sum of cardiac glycosides in terms of

on konvalatoksin 30,0%

0.125 mg

Auxiliary substances of the core:

Potato starch

44.625 mg

Magnesium dihydrogen phosphate

(magnesium phosphate monosubstituted) tetrahydrate

10,000 mg

Aerosil (silicon dioxide colloidal)

8.750 mg

Calcium stearate

1,500 mg

Shell accessories:

Sugar (sucrose)

92.388 mg

Magnesium carbonate basic (magnesium hydroxycarbonate)

26.255 mg

Titanium dioxide

3,760 mg

Aerosil (silicon dioxide colloidal)

1.642 mg

Polyvinylpyrrolidone

low molecular weight medical (povidone)

0.835 mg

Beeswax

0.065 mg

Vaseline oil (paraffin liquid)

0.055 mg
Description:

Tablets are round, biconvex, covered with a coat, white.

Pharmacotherapeutic group:Spasmolytic agent of plant origin
ATX: & nbsp
  • Other drugs for the treatment of urological diseases (including antispasmodics)
    • Pharmacodynamics:

    Combined drug. Has spasmolytic, diuretic and anti-inflammatory effect. Promotes the removal of renal concrements consisting of oxalates and calcium phosphates. Relieves or reduces pain in renal colic. Increases diuresis. Acidifies urine with its persistent alkaline reaction.

    Pharmacokinetics:

    No data available.

    Indications:

    Phosphate and oxalate nephrourolytiasis, including complicated by calculous pyelonephritis.

    Prevention of relapse after surgical removal of kidney stones or their independent departure.

    Saline diathesis (phosphaturia, oxaluria).

    Contraindications:

    Hypersensitivity to the components of the drug, increased sensitivity to salicylates (including aspirin triad - a combination of bronchial asthma, recurrent nasal polyposis and paranasal sinuses and intolerance to acetylsalicylic acid), erosive and ulcerative lesions of the gastrointestinal tract during an exacerbation, bronchial asthma,chronic heart failure, cardiosclerosis, myocardial infarction, angina pectoris, ventricular tachycardia, endocarditis, myocarditis, AV-blockade II-III arterial hypertension, blood clotting disorders, severe renal failure, acute and chronic glomerulonephritis, severe liver dysfunction, hearing loss, vestibular apparatus pathology, concomitant use of methotrexate at a dose of 15 mg per week or more, sugarase / isomaltase deficiency, intolerance fructose, glucose-galactose malabsorption, age to 18 years.

    Carefully:

    With concomitant therapy with anticoagulants; peptic ulcer of stomach and duodenum (in the anamnesis); congenital hyperbilirubinemia (syndromes Gilbert, Dubin-Johnson and Rotor); gout, hyperuricemia; renal and / or liver failure; chronic obstructive pulmonary disease, hay fever, nasal polyposis, concomitant use of methotrexate in a dose of less than 15 mg per week.

    If you have one of the listed diseases, Before taking the drug, consult a doctor.

    Pregnancy and lactation:

    It is not recommended for use in pregnancy and during breastfeeding because of the lack of safety data for this category of patients.

    Dosing and Administration:

    The drug is prescribed by a doctor!

    Before using the drug should consult a doctor.

    Inside, before eating 2-4 tablets 3 times a day for 20-30 days. Repeated courses after 1-1,5 months as agreed with the doctor.

    Patients with inflammatory diseases of the gastrointestinal tract outside the period of exacerbation should take the drug after a meal, as possible exacerbation of peptic ulcer of the stomach and duodenum.

    In order to prevent relapse after the operative removal of the stone or its spontaneous withdrawal should take 2 tablets 3 times a day for 2-3 months.

    The course of treatment is repeated 4-6 months after the doctor's recommendation.

    Side effects:

    Allergic reactions (skin rash, itching, urticaria, angioedema), aspirin asthma (acute attacks of suffocation), NSAID-gastropathy, epigastric pain, dyspepsia (nausea, vomiting, heartburn, diarrhea), decreased blood clotting, bleeding ,bronchospasm, swelling, increased blood pressure, arrhythmias, headache, dizziness, hearing loss, tinnitus, impaired liver / kidney function, increased sweating.

    If any of the side effects listed in the manual are aggravated, or if you notice any other side effects not listed in the instructions, inform the doctor about it.

    Overdose:

    In case of an overdose, it is possible to increase dose-dependent side effects, including pain associated with the removal of stones.

    Symptoms of an overdose of cardiac glycosides: pronounced bradycardia, polytopic extrasystole, bigeminy or trigeminia, retardation of atrioventricular conduction, in severe cases, ventricular flutter and cardiac arrest.

    Treatment: when intoxication associated with an overdose of cardiac glycosides, take a break in their use, if necessary, prescribe potassium preparations and antiarrhythmics.

    Symptoms of an overdose of salicylamide:

    Light intoxication: nausea, vomiting, epigastric pain, tinnitus, dizziness, headaches, decreased vision and hearing are possible. These symptoms occur after the drug is discontinued.

    Significant overdose: confusion, shortness of breath, suffocation, dehydration, hyperthermia, coma, violation of acid-base balance (first - respiratory alkalosis, then - metabolic acidosis).

    Treatment: gastric lavage, intake of activated carbon, correction of acid-base balance (infusion of solutions of sodium bicarbonate, citrate, etc.), hemodialysis, fluid loss compensation, symptomatic therapy.

    Interaction:

    Salicylamide increases the effect of indirect anticoagulants, antiaggregants, fibrinolytics, as well as side effects of mineralocorticosteroids and glucocorticosteroids, estrogens, hepato- and nephrotoxic drugs. Reduces the effectiveness of antihypertensive drugs, diuretics, uricosuric medicines.

    Inductors of microsomal oxidation in the liver (including phenytoin, ethyl alcohol, barbiturates, rifampicin, phenylbutazone, tricyclic antidepressants) increase the metabolism of salicylamide.

    At simultaneous application with ethanol the risk of development of an acute pancreatitis increases.

    Antacids and cholestyramine reduce the absorption of salicylamide.

    Myelotoxic drugs increase manifestations of salicylamide hematotoxicity.

    On the background of treatment with salicylamide, side effects of methotrexate are increasing.

    Special instructions:

    Before using the drug should consult a doctor.

    The drug contains the glycoside of the lily of the valley, which should be taken into account for patients taking cardiac glycosides.

    Patients with diabetes should take into account that one tablet contains about 0.137 g of carbohydrates (0.011 XE).

    Effect on the ability to drive transp. cf. and fur:

    When using the drug, care should be taken when driving vehicles and engaging in other potentially hazardous activities requiring increased concentration and speed of psychomotor reactions.

    Form release / dosage:The tablets covered with a cover.
    Packaging:

    For 10 tablets in a contour mesh box made of polyvinylchloride film and aluminum foil printed lacquered.

    2, 3 or 5 contour mesh packages together with the instruction for use will be prevented in a pack of cardboard.

    Storage conditions:

    In a dry, the dark place at a temperature of no higher than 25 ° C.

    Keep out of the reach of children.

    Shelf life:

    2 years.

    Do not use after the expiration date.

    Terms of leave from pharmacies:On prescription
    Registration number:LP-003039
    Date of registration:18.06.2015
    Expiration Date:18.06.2020
    The owner of the registration certificate:VIFITEH, CJSC VIFITEH, CJSC Russia
    Manufacturer: & nbsp
    Representation: & nbspVIFITEH, CJSCVIFITEH, CJSC
    Information update date: & nbsp27.03.2018
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