The following side effects were more common than in isolated cases. The following criteria were used to estimate the incidence of adverse events: very often (> 1/10); often (> 1 / 100.1 / 10); sometimes (> 1/1000, 1/100); rarely (> 1/10 j000, 1/1000); extremely rare (1/10 000).
On the part of the hematopoiesis system: very often - neutropenia, anemia, thrombocytopenia, the attachment of secondary infections against the background of oppression of bone marrow hematopoiesis; often - a fever (38 ° C) against neutropenia; sometimes - sepsis, septicemia; extremely rare - complicated septicemia, in some cases leading to death. The smallest number of neutrophils is observed at 7-10 day from the beginning of therapy, recovery occurs in the next 5-7 days.
Cumulation of hematotoxicity was not observed.
From the side of the peripheral nervous system: very often - paresthesia, hyperesthesia, reduction or loss of deep tendon reflexes; often - weakness in the legs; sometimes - severe paresthesia with sensory and motor symptoms, usually reversible.
From the side of the cardiovascular system: sometimes - increase or decrease in blood pressure (BP), "flushes" of blood to the face and cold extremities; rarely - ischemic heart disease (IHD) (angina pectoris, myocardial infarction), severe hypotension, collapse; very rarely - tachycardia, palpitation, violation heart rate.
From the respiratory system: sometimes - shortness of breath, bronchospasm; rarely - interstitial pneumonia (with combination therapy with synthomycin), acute respiratory distress syndrome.
From the digestive system: very often - nausea, vomiting, stomatitis, constipation, diarrhea, transient increase in the activity of "liver" transaminases; rarely - pancreatitis, increased bilirubin level, intestinal paresis,
From the immune system: rarely anaphylactic shock, angioedema edema.
From the skin and skin appendages: often - alopecia; rarely - skin rashes.
Local reactions: often - pain / burning or redness at the injection site, change in vein color, phlebitis; when extravasation - inflammation of subcutaneous fat; possibly - necrosis of surrounding tissues.
Other: often - increased fatigue, myalgia, arthralgia, fever, pains of different localization, including pain in the chest, pain in the lower jaw and in the area of tumor formations; rarely - hyponatremia; very rarely - hemorrhagic cystitis and the syndrome of inadequate secretion of ADH.