Adverse reactions are systematized according to the system-organ classes and are listed according to the following gradation: very frequent - 1/10 appointments (≥ 10%); frequent - 1/100 appointments (≥1% but <10%); infrequent - 1/1000 appointments (≥0.1% but < 1%); rare - 1/10000 appointments (≥0.01% but <0,1%); very rare - less than 1/10000 appointments (<0.01%); post-marketing messages, the frequency can not be estimated from the available data.
Infectious and parasitic diseases
Often: bacterial, viral and fungal infections without neutropenia, various localizations.
Often: bacterial, viral or fungal infections resulting from myelosuppression and / or immunosuppression (neutropenic infection) are usually reversible with appropriate treatment.
Frequency unknown: neutropenic sepsis.
Violations of the blood and lymphatic system
Often: myelosuppression, leading to neutropenia (the smallest number of neutrophils is observed on the 7-10th day from the start of therapy, recovery occurs in the next 5-7 days, cumulation of hematotoxicity is not observed), anemia, leukopenia, thrombocytopenia.
Often: grade 4 neutropenia, associate from increase body temperature above 38 ° C, febrile neutropenia.
Infrequently: sepsis, septicemia.
Disorders from the metabolism and nutrition
Frequency unknown: Heavy hyponatremia.
Disorders of the psyche
Often: insomnia.
Disturbances from the nervous system
Often: neurological disorders, including reduction or loss
tendon reflexes.
Often: neuromotor disorders, headache, dizziness, a disorder of taste perception.
Infrequently: ataxia.
Disturbances on the part of the organ of sight
Often: impaired visual perception.
Heart Disease
Infrequently: heart failure,disturbance of the heart rhythm.
Frequency unknown: myocardial infarction patients with heart disease in
history or risk factors of cardiovascular disease,cardiovascular diseases.
Vascular disorders
Often: arterial hypertension,arterial hypotension.
Disturbances from respiratory system, chest organs and
the mediastinum
Often: shortness of breath, cough.
Disorders from the gastro-intestinal tract
Often: nausea, vomiting, diarrhea,anorexia, stomatitis, abdominal pain, constipation,
gastric disorders.
Often: esophagitis, dysphagia.
Infrequently: paralytic intestinal obstruction.
Frequency unknown: gastrointestinal bleeding.
Disorders from the liver and bile ducts
Often: abnormal liver function.
Disturbances from the skin and subcutaneous fabrics
Often: alopecia (usually mild degree).
Often: skin reactions.
Musculoskeletal disorders system and connective tissue
Often: arthralgia, pain in the temporal-mandibular joint, myalgia.
Infringements from kidneys and urinary tract
Often: dysuria, other genitourinary violations.
General disorders and disorders in place introduction of
Often: weakness, bad state of health, fever.
Often: Pain, including pain in the area a tumor, a chill.
Laboratory and instrumental data
Often: decrease in body weight.
Often: increase in body weight.