Meglumine acridone acetate (Meglumini acrid? Nacetas)

Pharmacodynamics Pharmacokinetics Indications Carefully Contraindications Dosing and Administration Side effects
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Clinical and pharmacological group: & nbsp

Interferon Inductors

Included in the formulation
  • Cycloferon®
    pills inwards 
    POLISAN NTPF, LLC     Russia
  • Cycloferon®
    solution w / m in / in 
    POLISAN NTPF, LLC     Russia
  • Cycloferon®
    liniment locally 
    POLISAN NTPF, LLC     Russia
    • Included in the list (Order of the Government of the Russian Federation No. 2782-r of 30.12.2014):

    VED

    АТХ:

    L.03.A.X   Other immunostimulants

    Pharmacodynamics:

    It stimulates the production of alpha, beta and gamma interferons (up to 60-80 U / ml and higher) by leukocytes, macrophages, T- and B-lymphocytes, epithelial cells, as well as tissues of the spleen, liver, lungs, brain. Penetrates the cytoplasm and nuclear structures, induces the synthesis of "early" interferons. Activates T-lymphocytes and natural killer cells, normalizes the balance between subpopulations of T-helpers and T-suppressors. Promotes correction of the immune status in immunodeficient states of various genesis, including HIV-mediated ones.

    It is active against viruses of tick-borne encephalitis, influenza, hepatitis, herpes, cytomegalovirus, HIV, various enteroviruses, chlamydia.

    Pharmacokinetics:

    When administered inside the maximum allowable dose Cmax in blood is achieved after 2-3 hours, the concentration gradually decreases after 7 hours, after 24 hours it is found in trace amounts. When parenterally administered at the maximum allowable dose Cmax in the blood is reached after 1-2 hours. After 24 hours it is found in trace amounts.

    Passes through the blood-brain barrier. The half-life is 4-5 hours. Do not cumulate with prolonged use.

    Indications:As part of complex therapy and depending on the dosage form: infections - HIV-conditionede, cytomegalovirusherpes, herpetic; urogenital, including chlamydia, neuroinfections (serous meningitis, tick-borne borreliosis, multiple sclerosis, arachnoiditis and others), acute and chronic viral hepatitis (A, B, C, D); immunodeficiency states of different etiology (postoperativeth period, burns, chronic bacterial and fungal infections, including bronchitis, pneumonia); Stomach ulcer and duodenal ulceroh intestines; oncological diseases; rheumatoid arthritis; degenerative-distaphic diseases of the joints (deforming osteoarthritis and others); skin diseases (neurodermatitis, eczema, dermatosis); influenza and acute respiratory viral infections; Genital herpes, urethritis and balanoposthitis (nonspecific, candida, gonorrhea,chlamydial and trichomonas etiology), vaginitis (bacterial, candidiasis); prevention of influenza and acute respiratory infections in children aged 4 years and older.
    ICD-10

    I.A50-A64.A56   Other chlamydial diseases, sexually transmitted diseases

    I.A50-A64.A59.0   Urogenital trichomoniasis

    I.A50-A64.A60   Anogenital herpetic viral infection [herpes simplex]

    I.A65-A69.A69.9   Spirochaetic infection, unspecified

    I.A70-A74.A74   Other diseases caused by chlamydia

    I.B00-B09.B00   Infections caused by the herpes simplex virus [herpes simplex]

    I.B15-B19.B17.1   Acute hepatitis C

    I.B15-B19.B16   Acute hepatitis B

    I.B15-B19.B15   Acute hepatitis A

    I.B15-B19.B17   Other acute viral hepatitis

    I.B15-B19.B18.2   Chronic viral hepatitis C

    I.B15-B19.B18.1   Chronic viral hepatitis B without delta-agent

    I.B15-B19.B19   Viral hepatitis, unspecified

    I.B20-B24.B20   Disease caused by the human immunodeficiency virus [HIV], manifested as infectious and parasitic diseases

    I.B25-B34.B25   Cytomegalovirus

    II.D37-D48.D48.9   Neoplasm of uncertain or unknown nature, unspecified

    III.D80-D89.D84.9   Immunodeficiency, unspecified

    VI.G00-G09.G03.9   Meningitis, unspecified

    VI.G00-G09.G03.0   Non-piogenic meningitis

    VI.G35-G37.G35   Multiple sclerosis

    X.J00-J06.J06.8   Other acute upper respiratory tract infections of multiple localization

    X.J10-J18.J10   Influenza caused by an identified influenza virus

    X.J10-J18.J11   Influenza, virus not identified

    X.J10-J18.J18   Pneumonia without clarification of the pathogen

    X.J40-J47.J42   Chronic bronchitis, unspecified

    XI.K20-K31.K26   Duodenal ulcer

    XI.K20-K31.K25   Stomach ulcer

    XII.L20-L30.L30.9   Dermatitis, unspecified

    XII.L20-L30.L20   Atopic dermatitis

    XIII.M05-M14.M06.9   Rheumatoid arthritis, unspecified

    XIII.M15-M19   Osteoarthritis

    XIV.N30-N39.N34   Urethritis and urethral syndrome

    XIV.N40-N51.N48.1   Balanoposthitis

    XIV.N70-N77.N74.4 *   Inflammatory diseases of female pelvic organs caused by chlamydiae (A56.1 +)

    XIV.N70-N77.N76   Other inflammatory diseases of the vagina and vulva

    XIX.T20-T32.T30   Thermal and chemical burns, unspecified

    XXI.Z20-Z29.Z29.8   Other specified preventive measures

    Contraindications:Hypersensitivitycirrhosis of the liver (in the stage of decompensation), pregnancy, breast-feeding, children's age (up to 4 years).
    Carefully:No data.
    Pregnancy and lactation:

    The category of FDA recommendations is not defined. Adequate and well-controlled studies in humans have not been conducted. In experiments on animals, reproductive, teratogenic and mutagenic toxicity was not revealed. Contraindicated.

    There is no information on the penetration into breast milk. Contraindicated.

    Dosing and Administration:

    Solution for injection, tablets.Adults: solution for injection - intramuscular or intravenous, single dose for adults 0.25-0.5 g, for children at the rate of 6-10 mg / kg body weight; tablets - inside, 0.5 h before meals, without chewing, single dose for adults 0.3-0.6 g, the dose for children is determined depending on age; 1 time per day according to the basic scheme for 1, 2, 4, 6, 8, 11, 14, 17, 20, 23, 26, 29 day depending on the disease.

    Liniment. Adults: intraurethral, ​​intravaginal, 1 time per day.

    Side effects:Allergic reactions.
    Overdose:Not described. Treatment symptomatic.
    Interaction:Compatible with all medicines (including antibiotics, vitamins, immunomodulatorth, interferons). When combined, can enhance the effect of antibiotics and antifungal drugs.
    Special instructions:

    In diseases of the thyroid gland, treatment should be carried out under the control of the endocrinologist.

    Treatment of chronic herpes infection is recommended to be supplemented with other antiviral drugs and vaccines.

    It is highly effective in rheumatic and other systemic diseases of connective tissue, suppressing autoimmune reactions and providing an anti-inflammatory and analgesic effect.

    Instructions
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