The incidence of side effects listed below was determined according to the following (classification of the World Health Organization): very often (more than 10%), often (more than 1% and less than 10%), infrequently (more than 0.1% and less than 1%), rarely (more than 0.01% and less than 0.1%), very rarely (less than 0.01%), including individual reports.
From the gastrointestinal tract: often - dyspepsia, nausea, vomiting, abdominal pain, constipation, flatulence, diarrhea; infrequently - transient changes in liver function (e.g., increase in transaminases or bilirubin), eructation, esophagitis, gastroduodenal ulcer, hidden or explicit gastrointestinal bleeding, stomatitis; rarely - perforation of the gastrointestinal tract, colitis, hepatitis, gastritis.
On the part of the hematopoiesis system: often - anemia; infrequently - a change in the blood formula, including a change in the leukocyte formula, leukopenia and thrombocytopenia.
From the skin: often - itching, skin rash, angioedema; infrequently - hives; rarely Stevens-Johnson syndrome, toxic epidermal necrolysis; very rarely - photosensitization, bullous eruptions, erythema multiforme.
From the respiratory system: rarely - bronchospasm.
From the central nervous system (including from the organs of hearing, the psyche): often - headache; infrequently - dizziness, drowsiness, vertigo; rarely - noise in the ears; very rarely - confusion, disorientation, emotional lability.
From the side of the cardiovascular system: often - peripheral edema; infrequently - increased blood pressure, a feeling of "tide" of blood to the skin of the face; rarely - a feeling of rapid heartbeat.
From the genitourinary system: infrequent - changes in renal function (increased serum creatinine and / or urea levels), impaired urination, including acute delay; very rarely acute renal failure.
From the viewpoint: rarely - conjunctivitis, visual impairment, incl. blurred vision.
Allergic reactions: very rarely - angioedema and hypersensitivity reactions of immediate type, incl. anaphylactoid / anaphylactic reactions.