Metaproth - instructions for use, dose, side effects, contraindications

Active substanceEthylthiobenzimidazoleEthylthiobenzimidazole

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capsules inwards

Dosage form: & nbspcapsules

Composition:

Active substance:

ethylthiobenzimidazole hydrobromide monohydrate 50 mg or 125 mg, or 250 mg (in recalculated for ethylthiobenzimidazole hydrobromide).

Excipients:

for the dosage of 50 mg: giprolose - 1.7 mg, silicon dioxide colloidal - 4.0 mg, lactose monohydrate - 117.6 mg, magnesium stearate - 1.7 mg;

for the dosage of 125 mg: giprolose - 1.95 mg, silicon dioxide colloid - 4,55 mg, lactose monohydrate - 66.5 mg, magnesium stearate - 2.0 mg;

for the dosage of 250 mg: giprolose - 3.9 mg, silicon dioxide colloidal - 9.1 mg, lactose monohydrate - 133.0 mg, magnesium stearate - 4.0 mg.

Hard gelatin capsules contain:

for the dosage of 50 mg - gelatin 47.136 mg, ferric iron oxide yellow (E 172) 0.0576 mg, iron oxide red dye (E 172) 0.0384 mg, titanium dioxide (E 171) 0.768 mg;

for the dosage of 125 mg - gelatin 61.866 mg, ferric iron oxide yellow (E 172) 0,0756 mg, iron oxide red dye (E 172) 0.0504 mg, titanium dioxide (E 171) 1.008 mg;

for the dosage of 250 mg - gelatin 94.729 mg, ferric iron oxide yellow (E 172) 0.0038 mg, iron oxide red dye (E 172) 0.1152 mg, titanium dioxide (E 171) 1.152 mg.

Description:

Dosage 50 mg - capsules No. 3, body white, the lid is orange.

Dosage of 125 mg - capsules No. 2, body white, the lid is orange.

Dosage of 250 mg - capsules No. 0, body white, cover orange with a slight brownish hue of color.

The contents of the capsules are a mixture of powder and granules white or white with a creamy shade of color.

Pharmacotherapeutic group:Adaptogenic agent

ATX: & nbsp

A.13.A Tetanus preparations

Pharmacodynamics:

The drug has nootropic, regenerative, antihypoxic, antioxidant and immunomodulating activity. The mechanism of action is to activate the synthesis of RNA, and then proteins, including enzyme and related to the immune system. There is an activation of the synthesis of gluconeogenesis enzymes, which ensure the utilization of lactate (a limiting factor in working capacity) and the resynthesis of carbohydrates - the source of energy under intensive loads, which leads to an increase in physical performance. Strengthening the synthesis of mitochondrial enzymes and structural proteins of the mitochondria ensures an increase in energy production and the maintenance of a high degree of conjugation of oxidation with phosphorylation. Preservation of a high level of ATP synthesis with oxygen deficiency promotes severe antihypoxic and anti-ischemic activity.Enhances the synthesis of antioxidant enzymes and has a pronounced antioxidant activity. Increases the body's resistance to the effects of extreme factors - physical activity, stress, hypoxia, hyperthermia. Increases working capacity during physical activity. Has a pronounced anti-asthenic effect, accelerates recovery processes after extreme effects.

Pharmacokinetics:

After ingestion it is well absorbed from the gastrointestinal tract, is actively metabolized in the liver. After a single reception of the detectionin the blood after 30 minutes, the maximum effect is achieved after 1-2 hours, the duration of the action is 4-6 hours. Against the background of the course, the effect usually increases in the first 3-5 days, then it is steadily maintained at the achieved level. With prolonged course continuous reception, especially in large doses, there may be a tendency to cumulate the drug with an increase in its concentration in the blood by 10-12 days of use.

Indications:

Increase and restoration of efficiency, including in extreme conditions (heavy physical exertion, hypoxia, overheating). Adaptation to the impact of various extreme factors.

Asthenic disorders of various nature (with neurasthenia, somatic diseases, after severe infections and intoxications, pre- and postoperative period during surgical interventions).

As part of complex therapy: a craniocerebral trauma, meningitis, encephalitis, cerebral circulation disorders, cognitive disorders.

Contraindications:

Hypersensitivity, hypoglycemia, expressed violations of the liver, pregnancy, lactation, epilepsy, arterial hypertension, glaucoma, coronary heart disease, arrhythmias, lactase deficiency, lactose intolerance, glucose-galactose malabsorption, children's age.

Dosing and Administration:

Inside, after eating.

Adults 250 mg (1 capsule 250 mg each or 2 capsules of 125 mg) 2 times a day.

If necessary, the daily dose ofup to 750 mg (500 mg in the morning and 250 mg bybarely lunch), patients with a body weight of over 80 kg - up to 1000 mg (500 mg twice a day).

The course of treatment is 5 days. Depending on the effect of therapy is carried out on average 2-3 courses (less often 1 or 4-6), to avoid cumulation of drug between reko coursesMend to do a two-day break.

To improve efficiency in extreme conditions of the drug take 40-60 minutes before the upcoming activity in a dose of 500-750 mg. When continuation of work drug produced after 6-8 hours in a dose 250 mg. The maximum daily dose - 1500 mg, and in the following day 1000 mg.

Side effects:

Frequency of occurrence of collateral effects: very often (more than 10%), often (1-10 %), infrequently (0.1 - 1%), rarely (0.01 - 0.1%), very rarely (<0.01%, including single cases with unidentified frequency).

From the central nervous system: very often - headache, facial hyperemia, sleep disturbance, anxiety; very rarely - paresthesia, convulsions.

From the side of the cardiovascular system: very rarely - increased blood pressure, tachycardia.

From the digestive system: rarely - nausea, vomiting, unpleasant sensations in the stomach and liver. Allergic reactions: often hives, allergic conjunctivitis, allergic rhinitis.

In case of adverse reactions, including those not mentioned above, you should reduce the dose or stop taking the medication, as well as inform the treating doctor.

Overdose:

Symptoms of increased excitability, disturbance of night sleep.

Treatment: gastric lavage, reception of activated charcoal, if necessary - symptomatic therapy, should reduce the dose or stop taking the drug.

Interaction:

Inhibitors of microsomal liver enzymes CYP1A2, CYP2C9, CYP2D6, CYP3A4 (eg, cimetidine) can increase the concentration of the drug in the blood.

Strengthens the positive effects of metabolic drugs (including inosine), nootropic drugs (including piracetam), antihypoxants (including trimetazidine), potassium and magnesium aspa-raginate, glutamic acid, vitamins (including alpha-tocopherol), as well as antianginal drugs (nitrates, beta-blockers).

Special instructions:

Do not take in the evening (possible falling asleep).

During the treatment, a diet rich in carbohydrates is recommended.

Form release / dosage:

Capsules 50 mg, 125 mg, 250 mg.

Packaging:

For 10 capsules of a single dosage in a contiguous cell package.

2 or 5 contour mesh packages with instructions for use in a pack of cardboard.

For 100 capsules of a single dosage in a polymer can.

Each bank is polymer with instructions for use in a pack of cardboard.

Storage conditions:

In a dry, protected from light place at a temperature of no higher than 25 ° C. Keep out of the reach of children.

Shelf life:

2 of the year. Do not use after the expiration date printed on the package.

Terms of leave from pharmacies:On prescription

Registration number:LSR-006795/09

Date of registration:26.08.2009 / 04.10.2013

Expiration Date:Unlimited

The owner of the registration certificate:Anvilab, OOO Anvilab, OOO Russia

Manufacturer: & nbsp

FARMPROJECT, CJSC Russia

Information update date: & nbsp07.05.2018

Illustrated instructions

Instructions

Metaproth® (Metaprote®)