Ethylthiobenzimidazole - instructions for use, dose, side effects, contraindications

Clinical and pharmacological group: & nbsp

Included in the formulation

Metaproth®

capsules inwards

Anvilab, OOO Russia

АТХ:

A.13.A Tetanus preparations

Pharmacodynamics:

A drug with adaptogenic action. Has nootropic, regenerative, antihypoxic, antioxidant and immunomodulating activity.

The mechanism of action is to activate the synthesis of RNA, and then proteins, including enzyme and related to the immune system. There is an activation of the synthesis of gluconeogenesis enzymes, which ensure the utilization of lactate (a limiting factor in working capacity) and the resynthesis of carbohydrates - the source of energy under intensive loads, which leads to an increase in physical performance. Strengthening the synthesis of mitochondrial enzymes and structural proteins of the mitochondria ensures an increase in energy production and the maintenance of a high degree of conjugation of oxidation with phosphorylation. Preservation of a high level of ATP synthesis with oxygen deficiency promotes severe antihypoxic and anti-ischemic activity.

Enhances the synthesis of antioxidant enzymes and has a pronounced antioxidant activity. Increases the body's resistance to the effects of extreme factors - physical activity, stress, hypoxia, hyperthermia. Increases working capacity during physical activity.

Has a pronounced anti-asthenic effect, accelerates recovery processes after extreme effects.

The maximum effect is achieved 1-2 hours after taking the drug, the duration of the action is 4-6 hours. Against the background of the course, the effect usually increases in the first 3-5 days, then it is stably maintained at the reached level.

Pharmacokinetics:

After oral administration, it is well absorbed from the digestive tract. After a single dose is detected in the blood after 30 minutes. With prolonged course continuous use, especially in high doses, there may be a tendency to accumulate the drug with an increase in its concentration in the blood by 10-12 days of use.

Indications:

Increase and restoration of efficiency, including in extreme conditions (heavy physical exertion, hypoxia, overheating).

Adaptation to the impact of various extreme factors.

Asthenic disorders of various nature (with neurasthenia, somatic diseases, after severe infections and intoxications, in the pre- and postoperative period during surgical interventions).

As a part of complex therapy of the suffered craniocerebral trauma, meningitis, encephalitis, cerebrovascular disorders, cognitive disorders.

ICD-10

V.F00-F09.F06.6 Organic emotional labile [asthenic] disorder

V.F00-F09.F07 Personality and behavioral disorders due to illness, damage or dysfunction of the brain

V.F00-F09.F07.2 Postcontasia syndrome

V.F40-F48.F43 Reaction to severe stress and adaptation disorders

V.F40-F48.F45.3 Somatoform dysfunction of the autonomic nervous system

V.F40-F48.F48.0 Neurasthenia

V.F50-F59.F51.1 Drowsiness [hypersomnia] inorganic etiology

VI.G00-G09.G00 Bacterial meningitis, not elsewhere classified

VI.G00-G09.G04 Encephalitis, myelitis and encephalomyelitis

IX.I60-I69.I69 Effects of cerebrovascular disease

IX.I60-I69.I67.9 Cerebrovascular disease, unspecified

XXI.Z40-Z54.Z54 Condition of recovery

XXI.Z55-Z65.Z58 Problems related to physical factors of the environment

XIX.T90-T98.T90 Consequences of head injuries

XVIII.R50-R69.R53 Malaise and fatigue

Contraindications:

Hypoglycemia.
Pronounced violations of the liver.
Epilepsy.
Arterial hypertension.
Glaucoma.
IHD.
Arrhythmias.
Lactase insufficiency, lactose intolerance, glucose-galactose malabsorption syndrome.
Pregnancy.
Lactation period.
Childhood.
Hypersensitivity to the components of the drug.

Carefully:

Not noted.

Pregnancy and lactation:

The use of the drug is contraindicated in pregnancy and lactation.

Dosing and Administration:

The drug is prescribed inside, after eating.

Adults appoint 250 mg (1 capsule of 250 mg or 2 capsules of 125 mg) 2 times a day. If necessary, the daily dose is increased to 750 mg (500 mg in the morning and 250 mg in the afternoon), and for patients with a body weight above 80 kg - up to 1 g (500 mg twice a day).

The course of treatment is 5 days. Depending on the effect of therapy, an average of 2-3 courses (less often 1 or 4-6), in order to avoid cumulation of the drug between the courses it is recommended to take a break in 2 weeks.

To improve performance in extreme conditions, the drug is taken for 40-60 minutes before the upcoming activity at a dose of 500-750 mg. With the continuation of the work, a second dose is given after 6-8 hours at a dose of 250 mg. The maximum daily dose is 1.5 g, and the next day - 1 g.

Side effects:

From the side nervous system and sense organs: irritability, anxiety, headache, sleep disturbance.

From the side organs of the digestive tract: nausea, rarely - vomiting, unpleasant sensations in the epigastric region.

Other: hyperemia of the face.

Overdose:

Symptoms: increased excitability, disturbance of night sleep.

Treatment: gastric lavage, the reception of activated charcoal, if necessary - symptomatic therapy.

Interaction:

Inhibitors of microsomal liver enzymes CYP1A2, CYP2C9, CYP2D6, CYP3A4 (for example, cimetidine) can increase the concentration of the drug in the blood.

Strengthens the positive effects of metabolic drugs (including inosine), nootropic drugs (including piracetam), antihypoxic drugs (including trimetazidine), potassium and magnesium aspartate, glutamic acid, vitamins (including α-tocopherol), and also anti-anginal agents (nitrates, beta-blockers).

Special instructions:

To avoid disturbances in sleep, the last dose should be taken no later than 16 hours.

During the treatment should adhere to a diet rich in carbohydrates.

Instructions

Ethylthiobenzimidazole (Aethylthiobenzymidazolum)