Active substanceTrifosadeninTrifosadenin
Dosage form: & nbspsolution for intravenous administration
Composition:

In 1 ml of the solution contains: active substance - trifradsenin disodium trihydrate (in terms of adenosine triphosphate) 10 mg, Excipients - sodium carbonate anhydrous, sodium hydrogen carbonate (sodium bicarbonate), disodium edetate, propylene glycol, water for injection.

Description:

Transparent colorless or almost colorless liquid.

Pharmacotherapeutic group:metabolic
ATX: & nbsp

C.01.E.B   Other drugs for the treatment of heart disease

Pharmacodynamics:

Sodium adenosine triphosphate (ATP) is a metabolic remedy, has antiarrhythmic effect, also has antihypertensive effect, expands coronary and cerebral arteries. Is a natural macroergic compound. Formed in the body as a result of oxidative reactions and in the process of glycolytic cleavagecarbohydrates. Contained in many organs and tissues, but most of all - in skeletal muscles. Improves metabolism and energy supply of tissues. Due to its splitting into ADP and inorganic phosphate, ATP releases a large amount of energy used for muscle contraction, synthesis of protein, urea, intermediate products of metabolism, etc. Under the influence of ATP, blood pressure and relaxation of smooth muscles decrease, nerve impulses in vegetative ganglia improve and transmission of excitation from the vagus nerve to the heart, increases the contractility of the myocardium. After a transdermal introduction, it penetrates into the cells of the organs, where it splits into adenosine and inorganic phosphate with energy release. Subsequently, cleavage products are included in the synthesis of ATP. The antiarrhythmic effect is due to the adenosine formed during the decay of ATP, which suppresses the automatism of the sinus-atrial node and Purkinje fibers (calcium channel blockade and increased permeability for potassium ions).

Indications:

Suppression of paroxysms of supraventricular tachycardia (excluding fibrillation and / or atrial flutter).

Contraindications:

Hypersensitivity, acute myocardial infarction, arterial hypotension, inflammatory lung diseases.

Dosing and Administration:The drug is administered intravenously quickly into the central or large peripheral vein 3 mg for 2 seconds under the control of the electrocardiogram and blood pressure; if necessary, after 1-2 minutes, re-enter 6 mg of the drug, after 1-2 minutes, 12 mg; introduction, terminate with the development of atrioventricular blockade at any stage of drug administration.
Side effects:

Allergic reactions are possible (itching, skin hyperemia); nausea, hyperemia of the facial skin, headache, weakness.

After arresting the paroxysm of tachycardia, there may be short-term episodes of sinus bradycardia and / or atrioventricular blockade I-III Art. (requires ECG monitoring).

Overdose:

Because of the short half-life, undesirable phenomena quickly disappear. Competitive antagonists are theophylline and other methylxanthines.

Interaction:

Cardiac glycosides increase the risk of side effects (including arrhythmogenic effects).

Dipyridamole enhances the effect; theophylline, caffeine and other methylxanthines - weaken.

Special instructions:

Do not administer in large doses simultaneously with cardiac glycosides.

Form release / dosage:Solution for intravenous administration 10 mg / ml.
Packaging:

1 ml of the drug in an ampoule of colorless neutral glass (hydrolytic class I), with a point fracture.

10 ampoules per contour cell PVC / thermo-lacquered packaging films. On 1 contour cellular packing in a cardboard pack together with the instruction on application.

Storage conditions:

List B. Store in a dark place at a temperature of 3 to 7 ° C. Keep out of the reach of children.

Shelf life:

2 years. Do not use after the expiration date.

Terms of leave from pharmacies:On prescription
Registration number:LSR-005568/08
Date of registration:17.07.2008
The owner of the registration certificate:VIAL, LLC VIAL, LLC Russia
Manufacturer: & nbsp
Information update date: & nbsp18.10.2015
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